Article
Optics
Jianan Fang, Kun Huang, E. Wu, Ming Yan, Heping Zeng
Summary: This article introduces an infrared 3D imaging system capable of detecting three-dimensional structure and reflectivity information. The system operates at single-photon sensitivity and femtosecond timing resolution, enabling imaging under low-light conditions. By nonlinear frequency upconversion and recording with a silicon camera, the presented system achieves high lateral and depth resolutions for 3D reconstruction. Additionally, a numerical denoiser based on spatiotemporal correlation allows the retrieval of object profile and reflectivity even with a detected flux below 0.05 photons/pixel/second. This infrared 3D imager features high detection sensitivity, precise timing resolution, and wide-field operation, offering new possibilities in life and material sciences.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Review
Neurosciences
Ying Zhang, Yanjiang Wang, Ce Shi, Meixiao Shen, Fan Lu
Summary: Retinal changes can reflect brain pathology and serve as potential biomarkers for early diagnosis of Alzheimer's disease. Studies have shown that neurodegeneration and microvascular changes exist in AD, MCI, and even preclinical AD.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Optics
Robbie Murray, Ashley Lyons
Summary: Optical Coherence Tomography (OCT) is a 3D imaging technology that provides micron scale depth resolution, surpassing the millimetre scale typically achieved in Light Detection and Ranging (LiDAR). However, the lack of coherence in LiDAR scenes limits the feasibility of OCT. This paper presents a quantum interference inspired LiDAR approach that achieves OCT depth resolutions without requiring high levels of stability. The enhanced resolution opens doors for LiDAR in various applications.
Article
Optics
Daewoon Seong, Won Ki, Pilun Kim, Jaeyul Lee, Sangyeob Han, Soojin Yi, Hong Kyun Kim, Mansik Jeon, Jeehyun Kim
Summary: This study developed a virtual intraoperative OCT angiography integrated surgical microscope, which can simultaneously visualize the morphological tissue structure and microvasculature data of the surgical region, demonstrating its potential application in in vivo imaging and simulated surgeries of small animals.
OPTICS AND LASERS IN ENGINEERING
(2022)
Article
Optics
Xiangsen Guo, Guangyuan Ren, Jianbo Tang
Summary: In this study, an autocorrelation analysis-based optical coherence tomography (OCT) method was introduced for accurate measurement of blood flow velocity in the capillary network. The axial blood flow velocity was obtained from the phase change in the decorrelation period of the first-order field autocorrelation function (g1) of the OCT field data. The proposed method showed accurate measurement of axial speed in the range of 0.5-15 mm/s in phantom experiments, and it achieved robust axial velocity measurements with more than five times shorter acquisition time compared to phase-resolved Doppler optical coherence tomography (pr-DOCT) in living animals.
Article
Medicine, General & Internal
Lisa Toto, Maria Ludovica Ruggeri, Federica Evangelista, Chiara Trivigno, Rossella D'Aloisio, Chiara De Nicola, Pasquale Viggiano, Emanuele Doronzo, Marta Di Nicola, Annamaria Porreca, Rodolfo Mastropasqua
Summary: This study investigates the parameters of optical coherence tomography (OCT) and OCT angiography (OCTA) in patients with neovascular age-related macular degeneration (nAMD) and macular neovascularization (MNV) types 1, 2, and 3. The results showed significant differences in CVI, CMT, and ORCCFA between MNV 1 and the other two groups. CVI was significantly different between MNV 1 and healthy controls and between MNV 1 and MNV 2. ORCCFA and CMT were significantly different between MNV 1 and MNV 2. There was no statistically significant difference in subfoveal choroidal thickness (SFCT) among the three groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Analytical
Trevor Doherty, Susan McKeever, Nebras Al-Attar, Tiarnan Murphy, Claudia Aura, Arman Rahman, Amanda O'Neill, Stephen P. Finn, Elaine Kay, William M. Gallagher, R. William G. Watson, Aoife Gowen, Patrick Jackman
Summary: The diagnosis of prostate cancer is challenging, with accurate diagnosis benefiting a patient's quality of life and prognosis. A study utilizing multimodal images for automatic identification of prostate cancer found that the multimodal approach outperformed single modality models in distinguishing between G3/G4 tissue samples.
Article
Ophthalmology
Matteo Menean, Riccardo Sacconi, Beatrice Tombolini, Federico Fantaguzzi, Francesco Bandello, Giuseppe Querques
Summary: This study aimed to detect retinal neovascularization elsewhere (NVE), of the optic disc (NVD) and intraretinal microvascular abnormalities (IRMA) in treatment naive diabetic retinopathy (DR) using wide-field colour fundus photography (WF CFP), wide-field spectral-domain optical coherence tomography angiography (OCTA) and the combination of WF CFP and OCTA through overlay software. The results showed that OCTA had high levels of agreement in detecting NVE, NVD and IRMA, and combining WF CFP and OCTA further improved the detection of NVE and NVD.
Article
Physics, Applied
Shiqing Wu, Jing Li, Chao Tao, Xiaojun Liu
Summary: A transmission-mode photoacoustic microscope was developed to achieve quantitative images of two molecular components in tissues. By scanning the specimen once with a single-wavelength laser, a linear equation system was proposed to describe the relationship between signal magnitude and molecular concentrations. This method accurately quantifies concentrations and reveals gradients in mixtures, providing a potential solution to limitations of multiple excitations.
APPLIED PHYSICS LETTERS
(2022)
Review
Dentistry, Oral Surgery & Medicine
Y. Xu, X. Deng, Y. Sun, X. Wang, Y. Xiao, Y. Li, Q. Chen, L. Jiang
Summary: Oral potentially malignant disorders (OPMDs) are a group of oral lesions that have a variable risk of transforming into oral cancer. Traditional oral examinations may miss early malignant lesions, but optical techniques offer noninvasive methods for detecting these changes. This article provides a comprehensive review of various optical imaging methods used in the diagnosis of OPMDs, discussing their advantages, limitations, and future challenges.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Pediatrics
Thanh-Tin P. Nguyen, Shuibin Ni, Shanjida Khan, Xiang Wei, Susan Ostmo, Michael F. Chiang, Yali Jia, David Huang, Yifan Jian, J. Peter Campbell
Summary: Advancements in portable OCT and OCTA have expanded the clinical role of OCT technology in ROP diagnosis and management, allowing for objective diagnosis, disease monitoring, mapping of vascular development, and dye-free visualization.
FRONTIERS IN PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Elena-Georgiana Dobre, Mihaela Surcel, Carolina Constantin, Mihaela Adriana Ilie, Ana Caruntu, Constantin Caruntu, Monica Neagu
Summary: Early diagnosis is crucial for effectively treating skin cancer. Emerging optical imaging techniques, such as RCM, OCT, MRI, NIR bioimaging, and PET, can provide non-invasive imaging data for early detection and monitoring of cutaneous tumors. These techniques can observe dynamic processes relevant to disease evolution, including blood flow, immune cell activation, and tumor energy metabolism. This review discusses the latest advances in imaging techniques for skin cancer detection and monitoring, highlighting the challenges and opportunities for their implementation in clinical practice and their potential to complement molecular and histological approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Optics
Marcin R. Strakowski, Paulina Strakowska, Jerzy Plucinski
Summary: Optical coherence tomography (OCT) is a non-contact and non-invasive method for evaluating semitrans-parent and scattering objects. Spectroscopic analysis applied to OCT measurements can improve the reading of latent fingerprints by enhancing thin film readability. This study describes the combination of spectroscopic analysis and OCT and discusses its benefits for thin film evaluation and fingerprint reading.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Biochemical Research Methods
Steve Frisken, Trevor Anderson, Armin Segref, Dirk Lorenser, Grant Frisken
Summary: HP-OCT is a parallel spectral domain imaging technology that is well-suited for imaging the anterior segment of the eye. This study demonstrates that sparsely sampled volumes can be registered without active eye tracking to produce motion artifact-free 3D volumes. The anterior volume provides comprehensive 3D biometric information, including lens position, curvature, epithelial thickness, tilt, and axial length. Moreover, by changing a detachable lens, high-resolution anterior volumes and posterior volume images for preoperative assessment of the posterior segment can be captured. Importantly, the retinal volumes have the same Nyquist range as the anterior imaging mode.
BIOMEDICAL OPTICS EXPRESS
(2023)
Review
Oncology
Hang Long, Jiaqi Ji, Lijuan Chen, Jiayue Feng, Jie Liao, Yang Yang
Summary: Lung cancer is a major cause of cancer-related death globally, including China, mainly due to delayed diagnosis. Current early screening strategies for lung cancer have limited value. Endobronchial optical coherence tomography (EB-OCT) is a non-invasive, accurate, and repeatable technology that shows potential for early screening and diagnosis of lung cancer. In this review, we discuss the structure and strengths of EB-OCT and its applications in various aspects of lung cancer diagnosis and treatment, including differential diagnosis, early screening, biopsy assistance, and palliative treatment. The challenges and obstacles in developing and implementing EB-OCT in clinical practice are also analyzed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Orthopedics
Paul Cernohorsky, Simon D. Strackee, Geert J. Streekstra, Eroen P. van den Wijngaard, Jos A. E. Spaan, Maria Siebes, Ton G. van Leeuwen, Daniel M. de Bruin
Summary: This study utilized CT-mediated catheter-based optical coherence tomography to digitally reconstruct the articular surface of the TMC joint and assess cartilage thickness in comparison to cryomicrotome data. The results showed a near-perfect agreement between OCT and cryomicrotome thickness measurements. This approach enables accurate cartilage thickness measurements and encourages the development of intraarticular cartilage OCT for future clinical application.
Article
Biochemical Research Methods
Anouk L. Post, Henricus J. C. M. Sterenborg, Fransien G. Woltjer, Ton G. van Leeuwen, Dirk J. Faber
JOURNAL OF BIOMEDICAL OPTICS
(2020)
Article
Gastroenterology & Hepatology
M. D. Slooter, D. M. de Bruin, W. J. Eshuis, D. P. Veelo, S. van Dieren, S. S. Gisbertz, M. I. van Berge Henegouwen
Summary: The study identified a significant predictive value of the time to fluorescent enhancement in the gastric conduit for predicting anastomotic leakage, which can serve as a threshold for identifying high-risk patients. Meanwhile, the times to enhancement at the planned anastomotic site and ICG watershed were predictive for the occurrence of strictures.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Oncology
Sanne M. Jansen, Daniel M. de Bruin, Mark I. van Berge Henegouwen, Paul R. Bloemen, Simon D. Strackee, Denise P. Veelo, Ton G. van Leeuwen, Suzanne S. Gisbertz
Summary: By evaluating gastric tube perfusion with SDF, parameters such as velocity, MFI, TVD, and PPV were accurate in observing perfusion decrease, while venous congestion plays an important role in the development of ischemia.
Article
Biochemical Research Methods
Anouk L. Post, Albert J. de Groof, Xu U. Zhang, Anne-Fre Swager, Kiki N. Fockens, Roos E. Pouw, Bas L. A. M. Weusten, Dirk J. Faber, Daniel M. de Bruin, Jacques J. G. H. M. Bergman, Ton G. van Leeuwen, Henricus J. C. M. Sterenborg, Wouter L. Curvers
Summary: This study utilized multidiameter single fiber reflectance spectroscopy (MDSFR) to improve surveillance of Barrett's esophagus, developing a classifier based on logistic regression analysis to predict the presence of neoplasia in other parts of the Barrett's segment with high sensitivity and specificity.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Urology & Nephrology
Marit Lucas, Ilaria Jansen, Ton G. van Leeuwen, Jorg R. Oddens, Daniel M. de Bruin, Henk A. Marquering
Summary: This study combines digital histopathology slides with clinical data using deep learning to predict the recurrence-free survival of patients with non-muscle-invasive bladder cancer (NMIBC). The results show that the deep learning-based model, which combines digital histopathology slides and clinical data, performs better in predicting recurrence compared to models using clinical data or image data only.
EUROPEAN UROLOGY FOCUS
(2022)
Article
Cell Biology
Naomi C. Buntsma, Aleksandra Gasecka, Yvo B. W. E. M. Roos, Ton G. van Leeuwen, Edwin van der Pol, Rienk Nieuwland
Summary: In this study, we found that EDTA improves the stability of plasma EVs and is more effective at inhibiting the release of platelet EVs compared to citrate when platelets are activated.
Article
Biology
Sanne M. Jansen, Daniel M. de Bruin, Leah S. Wilk, Mark I. van Berge Henegouwen, Simon D. Strackee, Suzanne S. Gisbertz, Ed T. van Bavel, Ton G. van Leeuwen
Summary: This study investigates the use of fluorescence imaging to evaluate perfusion in the gastric tube during surgery and its correlation with patient outcomes in terms of anastomotic leakage. The study found that poor fundus perfusion is a major factor for the development of anastomotic leakage. Parameters for the quantification of fluorescence signal were tested and compared with patient outcomes. The study concludes that quantitative perfusion imaging can provide early risk stratification of necrosis.
Article
Hematology
Naomi C. Buntsma, Mona Shahsavari, Aleksandra Gasecka, Rienk Nieuwland, Ton G. van Leeuwen, Edwin van der Pol
Summary: A practical procedure was developed to determine the optimal sample dilution for plasma in order to prevent swarm detection and maintain significant particle counts in clinical research studies. The optimal dilution factor was found to be ≤1.1×10^2-fold, and the count rate should be <1.1×10^4 events center dot s^(-1).
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2023)
Proceedings Paper
Engineering, Biomedical
M. J. Remmelink, Y. Rip, P. R. Bloemen, R. M. van den Elzen, J. R. Oddens, J. A. Nieuwenhuijzen, J. P. van der Voorn, T. G. van Leeuwen, T. M. de Reijke, D. M. de Bruin
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS III
(2023)
Article
Urology & Nephrology
Luigi A. M. J. G. van Riel, Rob A. A. van Kollenburg, Andre N. Vis, Pim J. van Leeuwen, Theo M. de Reijke, Daniel M. de Bruin, Jorg R. Oddens
Summary: TPLA treatment for localized PCa is safe and feasible, with good short-term QoL and functional outcomes.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Review
Surgery
M. D. Slooter, M. S. E. Mansvelders, P. R. Bloemen, S. S. Gisbertz, W. A. Bemelman, P. J. Tanis, R. Hompes, M. I. van Berge Henegouwen, D. M. de Bruin
Summary: This systematic review identified methods to quantify intraoperative fluorescence angiography (FA) of the gastrointestinal anastomosis and potential thresholds to predict patient outcomes, highlighting time to fluorescence as the most promising category for quantitation. Future research should focus on fluorescence-time curves, while consensus on study set-up, calibration, and validation of software programs is crucial for data comparison.
Article
Urology & Nephrology
Esmee I. M. L. Liem, Jan Erik Freund, Cemile Dilara Savci-Heijink, Jean J. M. C. H. de la Rosette, Guido M. Kamphuis, Joyce Baard, Joseph C. Liao, Ton G. van Leeuwen, Theo M. de Reijke, Daniel Martijn de Bruin
EUROPEAN UROLOGY FOCUS
(2020)