Glucose Oxidase Integrated Porphyrinic Covalent Organic Polymers for Combined Photodynamic/Chemodynamic/Starvation Therapy in Cancer Treatment

The anticancer effect of photodynamic therapy (PDT) is usuallyimpeded by the hypoxia microenvironment in solid tumors; thus, it requiresintegration with other treatment tactics to achieve an optimal anticancer efficacy.Porphyrin-containing nanotherapeutic agents are broadly used for PDT in tumortreatment. However, chemodynamic therapy (CDT) of porphyrin-basednamomaterials has been rarely reported. Here, a novel nanoscale porphyrin-containing covalent organic polymer (PCOP) was designed by the cross-linking of5,10,15,20-tetrakis(4-aminophenyl)porphyrin with 1,1 '-ferrocenedicarboxylic acidat room temperature. After glucose oxidase (GOx) was loaded, the obtainednanotherapeutic agent of PCOPs@GOx presented an augmented synergy of PDT,CDT, and energy starvation to suppress tumor growth upon near-infrared lightirradiation. In vitro and in vivo outcomes demonstrated that this multifunctionalnanoplatform not only realized excellent tumor inhibition but also provided a newtactic for designing chemodynamic/photodynamic/starvation combined therapy inone material.

Automated summary

A novel nanoscale porphyrin-containing covalent organic polymer was designed with enhanced synergistic effects of photodynamic therapy, chemodynamic therapy, and energy starvation by loading glucose oxidase, leading to effective tumor growth inhibition upon near-infrared light irradiation.