期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 8, 期 5, 页码 2131-2141出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.1c01598
关键词
carbon nanorods; type 2 diabetes mellitus; pancreatic protection; insulin resistance
资金
- Department of Biotechnology (DBT), India, through the Ramalingaswami Faculty Award [BT/RLF/Re-entry/45/2018]
- Cooperative Research Program of the Center for Companion Animal Research [PJ01476703]
- Gachon University [GCU-2019-0723]
This study reports a facile synthesis method for nitrogen-doped carbon nanorods (N-CNRs) and investigates their application in T2DM treatment. The experimental results demonstrate that N-CNRs can reduce blood glucose levels, ameliorate oxidative stress and inflammation, reverse pancreatic dysfunction, and attenuate hepatic steatosis.
Insufficient glucose control remains a critical challenge for type 2 diabetes mellitus (T2DM) patients with currently used therapeutic drugs, which can also have detrimental side effects. The facile synthesis of nitrogendoped carbon nanorods (N-CNRs) as therapeutic agents in a T2DM transgenic db/db mouse model is reported herein. N-CNRs are synthesized from silkworm powder without the assistance of any template and possess a hollow graphitic nature, rough surface, and good aqueous solubility, which make them ideal candidates for fabricating nanomedicines. N-CNRs are employed to reduce fasting blood glucose and ameliorate serum biomarker levels linked to oxidative stress and inflammation. Interestingly, through the downregulation of enhanced expression of glutathione peroxidase, superoxide dismutase, and catalase as well as inflammatory responses, N-CNRs reverse pancreatic dysfunction and normalize the secretory functions of pancreatic cells. Moreover, hepatic steatosis is attenuated by downregulating lipogenesis and increasing fatty acid oxidation. This finding may help in designing novel therapeutics for T2DM treatment
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