Article
Endocrinology & Metabolism
Flavia Agata Cimini, Ilaria Barchetta, Gea Ciccarelli, Frida Leonetti, Gianfranco Silecchia, Caterina Chiappetta, Claudio Di Cristofano, Danila Capoccia, Laura Bertoccini, Valentina Ceccarelli, Raffaella Carletti, Antonio Fraioli, Marco Giorgio Baroni, Sergio Morini, Maria Gisella Cavallo
Summary: This study found a significant association between NAFLD and VAT inflammation, fibrosis, and impaired microvascular density in obese individuals, with the degree of VAT inflammation correlating with hepatic injury severity and metabolic disturbances.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2021)
Article
Virology
Marcelle Dina Zita, Matthew B. Phillips, Johnasha D. Stuart, Asangi R. Kumarapeli, Anthony J. Snyder, Amairani Paredes, Vijayalakshmi Sridharan, Marjan Boerma, Pranav Danthi, Karl W. Boehme
Summary: This study reports that the M2 gene is a determinant of reovirus myocarditis. The substitution of the M2 gene from strain type 3 Dearing (T3D) into an otherwise type 1 Lang (T1L) genetic background converts the nonlethal T1L strain into a lethal infection and enhances reovirus replication and dissemination in vivo.
JOURNAL OF VIROLOGY
(2022)
Article
Immunology
Young-Su Yi, Han Gyung Kim, Ji Hye Kim, Woo Seok Yang, Eunji Kim, Deok Jeong, Jae Gwang Park, Nur Aziz, Suk Kim, Narayanan Parameswaran, Jae Youl Cho
Summary: The MyD88-Syk axis plays a critical role in macrophage-mediated inflammatory responses, and its function is enhanced by an upstream Src kinase activated by Rac1-generated filamentous actin (F-actin).
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Colton Martens, Lisa A. Dorn, Adam Kenney, Shyam A. Bansal, Jacob Yount, Federica A. Accornero
Summary: This study identifies BEX1 as a novel antiviral protein that plays a cardioprotective role in the heart during viral infection. It regulates cardiac immune responses to limit viral replication and its absence accelerates virus-induced heart failure and pathological remodeling, while its overexpression confers protection.
Review
Cell Biology
Amita G. Ghadge, Pallave Dasari, Jennifer Stone, Erik W. Thompson, Rebecca L. Robker, Wendy Ingman
Summary: The association between mammographic density and breast cancer risk has been well-established, with puberty identified as a critical time for breast development and adult mammographic density. The molecular and cellular mechanisms underlying the development of high mammographic density are still not fully understood.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Marina Fukano, Morag Park, Genevieve Deblois
Summary: Breast cancer cells exhibit diverse dependencies on metabolites and metabolic pathways, supporting tumor progression. The metabolic changes within breast tumors contribute to enhanced tumor growth and adaptation to microenvironmental stresses.
Article
Medicine, General & Internal
Yunan Han, Justin Xavier Moore, Graham A. Colditz, Adetunji T. Toriola
Summary: This study investigated the association between family history of breast cancer (FHBC) and mammographic breast density in premenopausal women. The results showed a positive correlation between FHBC and breast density, suggesting a heritable component of mammographic breast density. This highlights the importance of early annual screening for premenopausal women with a family history of breast cancer.
Article
Biochemistry & Molecular Biology
Daniel J. Puleston, Francesc Baixauli, David E. Sanin, Joy Edwards-Hicks, Matteo Villa, Agnieszka M. Kabat, Marcin M. Kaminski, Michal Stanckzak, Hauke J. Weiss, Katarzyna M. Grzes, Klara Piletic, Cameron S. Field, Mauro Corrado, Fabian Haessler, Chao Wang, Yaarub Musa, Lena Schimmelpfennig, Lea Flachsmann, Gerhard Mittler, Nir Yosef, Vijay K. Kuchroo, Joerg M. Buescher, Stefan Balabanov, Edward J. Pearce, Douglas R. Green, Erika L. Pearce
Summary: Polyamine synthesis plays a critical role in T cell activation and differentiation, regulating CD4(+) T cells' function and epigenetic remodeling. Studies have revealed the significance of polyamine metabolism in controlling the fate of T-H cell subsets, with deficiency leading to aberrant expression of cytokines and transcription factors.
Article
Oncology
Daniela Nahmias-Blank, Ofra Maimon, Amichay Meirovitz, Kim Sheva, Tamar Peretz-Yablonski, Michael Elkin
Summary: Postmenopausal, obese women have a higher risk of developing estrogen receptor-positive (ER+) breast tumors, which are resistant to therapies. The relationship between obesity and breast cancer differs in pre-menopausal and post-menopausal women. Elucidation of the molecular mechanisms behind obesity-related breast tumors is critical for disease prevention and treatment. Understanding these mechanisms could potentially prevent and intervene in the promotion of breast cancer associated with excess adiposity.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Dermatology
N. Abu Rached, T. Gambichler, L. Ocker, M. Skrygan, C. Seifert, C. H. Scheel, E. Stockfleth, F. G. Bechara
Summary: This study compared haptoglobin with previously proposed serum biomarkers for determining disease severity in HS patients. It was found that haptoglobin levels were significantly correlated with disease severity and were identified as the only independent marker predicting severe HS.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Immunology
Kyung Wook Heo, Kwang Pak, Arwa Kurabi, Allen F. Ryan
Summary: The study showed that LTB4 plays a functional role in OM disease, with its generation spread across different cell types. The reduction in middle ear leukocyte infiltration caused by LTB4 receptor inhibition indicates that LTB4 plays a major role in inflammatory cell recruitment.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Oncology
Uttom Kumar, Anastasia Ardasheva, Zimam Mahmud, R. Charles Coombes, Ernesto Yague
Summary: This passage discusses the different subtypes of breast cancer in terms of their genetic expression profiles and the role of FOXA1 in regulating drug sensitivity and resistance. By modulating FOXA1 expression levels, studies have shown that FOXA1 plays a significant role in tumor aggressiveness.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Review
Biochemistry & Molecular Biology
Yuan Wu, Xu Li, Qiong Li, Chienshan Cheng, Lan Zheng
Summary: The review examines mechanistic evidence for the connection between obesity and breast cancer, exploring the factors that promote tumor development or metastasis. It highlights the role of adipokines, metabolic pathways, inflammatory microenvironment, adipose stem cells, and miRNAs in breast cancer progression. The review also discusses possible therapeutic directions and the risks associated with autologous breast remodeling and fat transplantation. Furthermore, it explores the causes of the obesity paradox and the impact of enhanced immunity. Evaluating the balance between inflammation and immunity in obesity-induced breast cancer warrants further investigation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Food Science & Technology
Sara Castro-Barquero, Rosa Casas, Eric B. Rimm, Anna Tresserra-Rimbau, Dora Romaguera, J. Alfredo Martinez, Jordi Salas-Salvado, Miguel A. Martinez-Gonzalez, Josep Vidal, Miguel Ruiz-Canela, Jadwiga Konieczna, Emilio Sacanella, Jesus Francisco Garcia-Gavilan, Montse Fito, Ana Garcia-Arellano, Ramon Estruch
Summary: This study found that excessive visceral adipose tissue is associated with increased secretion of pro-inflammatory molecules, leading to systemic inflammation and obesity-related metabolic disturbances. The reduction in visceral adipose tissue is associated with improvements in various inflammatory and adiposity markers, especially insulin, c-peptide, and PAI-1 levels, which may contribute to a decrease in cardiometabolic disturbances observed in obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Oncology
Seok-Yeong Yu, Yi Luan, Rosemary Dong, Amirhossein Abazarikia, So-Youn Kim
Summary: Pancreatic cancer is one of the deadliest cancers in the US, and it is associated with unintended weight loss (cachexia) in patients even before diagnosis. However, the understanding of how pancreatic cancer leads to cachexia is limited, and there are few effective treatments available. This study demonstrates that cachexia in pancreatic cancer primarily results from the wasting of adipose tissue, and the loss of adipose tissue is associated with poor survival in patients.
Retraction
Biochemistry & Molecular Biology
Kotha Subbaramaiah, Robert Benezra, Clifford Hudis, Andrew J. Dannenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Retraction
Biochemistry & Molecular Biology
Kotha Subbaramaiah, Clifford Hudis, Sung-Hee Chang, Timothy Hla, Andrew J. Dannenberg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Oncology
Elizabeth Garrett-Mayer, Melinda W. Kaltenbaugh, Rebecca Spence, Suanna S. Bruinooge, Clifford A. Hudis, Dina Michels, Richard L. Schilsky
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Mark P. S. Dunphy, Christina Pressl, Nagavarakishore Pillarsetty, Milan Grkovski, Shanu Modi, Komal Jhaveri, Larry Norton, Bradley J. Beattie, Pat B. Zanzonico, Danuta Zatorska, Tony Taldone, Stefan O. Ochiana, Mohammad M. Uddin, Eva M. Burnazi, Serge K. Lyashchenko, Clifford A. Hudis, Jacqueline Bromberg, Heiko M. Schoder, Josef J. Fox, Hanwen Zhang, Gabriela Chiosis, Jason S. Lewis, Steven M. Larson
CLINICAL CANCER RESEARCH
(2020)
Article
Oncology
Alyssa A. Schatz, Thomas K. Oliver, Robert A. Swarm, Judith A. Paice, Deepika S. Darbari, Deborah Dowell, Salimah H. Meghani, Katy Winckworth-Prejsnar, Eduardo Bruera, Robert M. Plovnick, Lisa Richardson, Neha Vapiwala, Dana Wollins, Clifford A. Hudis, Robert W. Carlson
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2020)
Article
Oncology
Mark Jesus M. Magbanua, Laura H. Hendrix, Terry Hyslop, William T. Barry, Eric P. Winer, Clifford Hudis, Deborah Toppmeyer, Lisa Anne Carey, Ann H. Partridge, Jean-Yves Pierga, Tanja Fehm, Jose Vidal-Martinez, Dimitrios Mavroudis, Jose A. Garcia-Saenz, Justin Stebbing, Paola Gazzaniga, Luis Manso, Rita Zamarchi, Maria Luisa Antelo, Leticia De Mattos-Arruda, Daniele Generali, Carlos Caldas, Elisabetta Munzone, Luc Dirix, Amy L. Delson, Harold J. Burstein, Misbah Qadir, Cynthia Ma, Janet H. Scott, Francois-Clement Bidard, John W. Park, Hope S. Rugo
Summary: This study identified 4 novel prognostic groups in metastatic breast cancer (MBC) based on similarities in circulating tumor cell (CTC) trajectory patterns during chemotherapy. Patients with intermediate+high CTCs (19.4%) had significantly poorer outcomes and may benefit from more effective treatment. This novel prognostic classification approach may guide future prospective clinical trials in MBC.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2021)
Retraction
Oncology
Kotha Subbaramaiah, Patrick G. Morris, Xi Kathy Zhou, Monica Morrow, Baoheng Du, Dilip Giri, Levy Kopelovich, Clifford A. Hudis, Andrew J. Dannenberg
Editorial Material
Oncology
Clifford A. Hudis
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jennifer A. Ligibel, Luke Huebner, Hope S. Rugo, Harold J. Burstein, Debra L. Toppmeyer, Carey K. Anders, Cynthia Ma, William T. Barry, Vera Suman, Lisa A. Carey, Ann H. Partridge, Clifford A. Hudis, Eric P. Winer
Summary: In metastatic breast cancer patients, high rates of obesity and inactivity were observed, but they were not significantly associated with PFS and OS. Greater than 9 MET hours of PA per week may be marginally associated with improved PFS and OS outcomes.
JNCI CANCER SPECTRUM
(2021)
Meeting Abstract
Oncology
Cynthia X. Ma, Vera Suman, A. Marilyn Leitch, Souzan Sanati, Kiran Vij, Gary W. Unzeitig, Jeremy Hoog, Mark Watson, Olwen Hahn, Joseph Guenther, Abigail Caudle, Erika Crouch, Horacio Maluf, Amy Tiersten, Monica Mita, Wajeeha Razaq, Tina J. Hieken, Yang Wang, Travis Dockter, Jo Anne Zujewski, Anna Weiss, Kelly Hunt, Clifford Hudis, Eric P. Winer, Matthew J. Ellis, Lisa A. Carey, Ann H. Partridge
Meeting Abstract
Oncology
Matthew J. Ellis, Vera Suman, A. Marilyn Leitch, Souzan Sanati, Kiran Vij, Gary W. Unzeitig, Jeremy Hoog, Mark Watson, Olwen Hahn, Joseph Guenther, Abigail Caudle, Erika Crouch, Horacio Maluf, Mitch Dowsett, Amy Tiersten, Monica Mita, Wajeeha Razaq, Tina J. Hieken, Yang Wang, Travis Dockter, Jo Anne Zujewski, Anna Weiss, Clifford Hudis, Eric P. Winer, Kelly Hunt, Ann H. Partridge, Cynthia X. Ma, Lisa A. Carey
Letter
Oncology
Clifford A. Hudis, Richard L. Schilsky
JCO ONCOLOGY PRACTICE
(2020)
Article
Oncology
Alyssa A. Schatz, Thomas K. Oliver, Robert A. Swarm, Judith A. Paice, Deepika S. Darbari, Deborah Dowell, Salimah H. Meghani, Katy Winckworth-Prejsnar, Eduardo Bruera, Robert M. Plovnick, Lisa Richardson, Neha Vapiwala, Dana Wollins, Clifford A. Hudis, Robert W. Carlson
JCO ONCOLOGY PRACTICE
(2020)
Meeting Abstract
Oncology
Cynthia X. Ma, Vera J. Suman, A. Marilyn Leitch, Souzan Sanati, Kiran R. Vij, Gary Walter Unzeitig, Jeremy Hoog, Mark Watson, Olwen Mary Hahn, J. Michael Guenther, Abigail Suzanne Caudle, Travis Dockter, Larissa A. Korde, Anna Weiss, Kelly Hunt, Clifford A. Hudis, Eric P. Winer, Ann H. Partridge, Lisa A. Carey, Matthew James Ellis
JOURNAL OF CLINICAL ONCOLOGY
(2020)
Article
Oncology
Pedram Razavi, Maura N. Dickler, Payal D. Shah, Weiyi Toy, David N. Brown, Helen H. Won, Bob T. Li, Ronglai Shen, Neil Vasan, Shanu Modi, Komal Jhaveri, Betty Ann Caravella, Sujata Patil, Pier Selenica, Stephen Zamora, Aimee M. Cowan, Elizabeth Comen, Andy Singh, Anne Covey, Michael F. Berger, Clifford A. Hudis, Larry Norton, Rebecca J. Nagy, Justin I. Odegaard, Richard B. Lanman, David B. Solit, Mark E. Robson, Mario E. Lacouture, Edi Brogi, Jorge S. Reis-Filho, Mary Ellen Moynahan, Maurizio Scaltriti, Sarat Chandarlapaty