Article
Agriculture, Dairy & Animal Science
E. C. Kessler, R. M. Bruckmaier, J. J. Gross
Summary: The study compared the quality estimation of colostrum in cows, goats, and sheep using an optical Brix refractometer. Despite distinct between-species variations in colostrum composition, Brix refractometry proved to be an acceptable tool for on-farm estimations of colostrum quality in goats and sheep.
JOURNAL OF DAIRY SCIENCE
(2021)
Review
Biology
Tiantian Ke, Mengyu Zhao, Xiaoan Zhang, Yao Cheng, Yiming Sun, Penghui Wang, Chunhuan Ren, Xiao Cheng, Zijun Zhang, Yafeng Huang
Summary: The growth rate, carcass attributes, and meat quality traits of small ruminants are influenced by various factors, with the feeding system being one of the most important. This review evaluates the differences in how different feeding systems affect the growth performance, carcass characteristics, and meat quality of sheep and goats, and explores the effects of a new finishing strategy on these traits.
Article
Biochemistry & Molecular Biology
Ahmed K. Mahdi, Juan F. Medrano, Pablo J. Ross
Summary: We investigated the possibility of single-step genome editing in small ruminants using CRISPR-Cas9 zygote electroporation. We found that electroporation was more efficient than microinjection and successfully disrupted target genes in sheep and goat embryos.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Siquan Xia, Lina Zhang, Yiqian Zhang, Hongyang Han, Yanmei Hou, Tong Wu, Peng Zhou
Summary: This study purified bovine lactoferrin (BLF), caprine lactoferrin (CLF), and ovine lactoferrin (OLF) using ion-exchange chromatography and gel filtration chromatography. The effects of iron saturation on the physicochemical properties of lactoferrins were investigated. The results showed that iron saturation influenced the tertiary structure of lactoferrins, while the species did not affect the secondary structure. Increasing iron saturation enhanced the thermal stability of lactoferrins. These findings provide valuable information for the production and application of lactoferrins.
Article
Agriculture, Dairy & Animal Science
Clara Viviana Rua Bustamante, Pablo Cortes-Alcaide, Ronnal Esneyder Ortiz, John Jacobo Canas-Alvarez, Leyla Rios-de Alvarez
Summary: This study classified sheep and/or goat production systems in Cesar, Colombia. By analyzing survey data from farmers, three clusters of production systems - traditional, mixed, and specialized - were identified.
SMALL RUMINANT RESEARCH
(2022)
Article
Food Science & Technology
Asmaa Galal-Khallaf, Doaa Hussein, Sobhy El-Sayed Hassab El-Nabi
Summary: This study focused on the development of genetic techniques for the discrimination of six red meat species, showing low levels of species substitution in tested meat samples. The developed techniques have high potentials to be used as reliable and fast tools to avoid meat species substitutions.
JOURNAL OF FOOD SCIENCE
(2021)
Review
Veterinary Sciences
Nai-Chao Diao, Zi-Yang Chen, Jun-Feng Shi, Qi Wang, Chen-Yan Sheng, Bao-Yi Ma, Yang Yang, Yu-Han Sun, Kun Shi, Rui Du
Summary: This systematic review and meta-analysis analyzed the global prevalence of BVDV in sheep and goat populations, finding that prevalence is higher in middle-income countries than in high-income countries. There were no significant differences in prevalence rates by species of BVDV, sampling year, and test species.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Teshager Dubie, Betelhem Dagnew, Esrael Gelo, Wossene Negash, Fentaw Hussein, Mulatu Woldehana
Summary: This study investigated the prevalence of Peste des petits ruminant (PPR) infection in small ruminants in Ethiopia. The results showed a high seroprevalence of PPR virus infection, indicating the circulation of the virus in the study area. Species, sex, age, and herd size were found to be significantly associated with the occurrence of the disease.
BMC VETERINARY RESEARCH
(2022)
Article
Nutrition & Dietetics
Ankita Jena, Carlos A. Montoya, Karl Fraser, Caroline Giezenaar, Wayne Young, Jane A. Mullaney, Ryan N. Dilger, Debashree Roy, Warren C. Mcnabb, Nicole C. Roy
Summary: This study aimed to investigate the effect of consuming different ruminants' milk on the appearance of circulatory blood plasma metabolites in pigs. The results showed significant differences in the relative intensities of metabolites, particularly lipids, in the plasma between different milk treatments. These findings suggest that consuming different ruminants' milk may have an impact on early postnatal development in pigs.
FRONTIERS IN NUTRITION
(2023)
Article
Chemistry, Analytical
Viviana Carmen Ciuca, Carmen Otilia Rusanescu, Victor Viorel Safta
Summary: This paper investigates the depletion of levamisole residues in animal tissues. The study finds that in cattle, sheep, goats, and pigs, the level of levamisole residues decreases to below the established limit within a specific time frame after treatment. Residue depletion is faster in chickens compared to turkeys.
Article
Infectious Diseases
Murat Sevik
Summary: This study investigated the frequency and genetic diversity of pestiviruses in abortion cases in cattle and small ruminants in Turkey. The majority of pestivirus sequences belonged to BVDV-1, with the dominant genotypes being "Aydin-like" in bovine foetuses and "Konya-like" in sheep foetuses. The presence of an emerging genotype within Pestivirus I tentatively named "Konya-like" pestivirus was identified, and this information could be valuable for developing more effective vaccines against pestiviruses.
TRANSBOUNDARY AND EMERGING DISEASES
(2021)
Article
Reproductive Biology
Anna S. Krivonogova, Alexandra V. Bruter, Valeria A. Makutina, Yuliya D. Okulova, Leonid A. Ilchuk, Marina V. Kubekina, Alexandra Yu Khamatova, Tatiana Egorova, Vladimir S. Mymrin, Yuliya Yu Silaeva, Alexey V. Deykin, Maxim A. Filatov, Albina G. Isaeva
Summary: The study explores the use of recombinant AAV as a transduction tool to achieve genetic modifications in bovine embryos. It demonstrates that AAV1, AAV2, AAV6, and AAV-DJ have high transduction efficiency, highlighting the effectiveness of AAV as a genome editing tool for genetically modified cattle embryos.
Review
Biochemistry & Molecular Biology
Yulin Mu, Chengxiao Zhang, Taihua Li, Feng-Jie Jin, Yun-Ju Sung, Hee-Mock Oh, Hyung-Gwan Lee, Long Jin
Summary: Lactobacillus, important in food production and probiotics, can benefit from CRISPR/Cas9-based genome editing to improve strain efficiency and achieve traceless genome modification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Ouranios Tzamaloukas, Marina C. Neofytou, Panagiotis E. Simitzis, Despoina Miltiadou
Summary: This study found that organic farming practices influenced the fat and protein content, as well as the fatty acid profile of milk and dairy products. Compared to traditional farms, organic farms produced products with higher levels of fatty acids, mono-unsaturated fatty acids, and poly-unsaturated fatty acids.
Article
Virology
Zoltan Laszlo, Peter Pankovics, Gabor Reuter, Attila Csagola, Adam Balint, Mihaly Albert, Akos Boros
Summary: This study identified three novel picornaviruses and a potential new species Bopivirus B. Epidemiological investigation revealed that bopiviruses were most prevalent among <12-month-old ovine, caprine, and bovine. Phylogenetic analyses suggested the possibility of interspecies transmission of certain bopiviruses between ovine and caprine.
Article
Genetics & Heredity
Danika Bannasch, Kevin Batcher, Fabienne Leuthard, Michael Bannasch, Petra Hug, Denis J. Marcellin-Little, Peter J. Dickinson, Michaela Drogemuller, Cord Drogemuller, Tosso Leeb
Summary: The study identified two FGF4 retrogenes that cause dwarfism in dog breeds and evaluated their effects on body size. The retrogenes significantly reduced height at the shoulders and antebrachial length, with FGF4L1 having a greater effect than FGF4L2. FGF4L1 also influenced carpal valgus, while FGF4L2 increased head width.
Editorial Material
Agriculture, Dairy & Animal Science
Joana G. P. Jacinto, Irene M. Hafliger, Matthias Christen, Julia M. Paris, Franz R. Seefried, Cord Drogemuller
Article
Agriculture, Dairy & Animal Science
Irene M. Hafliger, Sonja Wolf-Hofstetter, Christina Casola, Udo Hetzel, Franz R. Seefried, Cord Drogemuller
Summary: In this study, a case of inherited cataract in livestock was identified, and a de novo mutation of the ADAMTSL4 gene was discovered through whole-genome sequencing. This finding suggests the potential role of the ADAMTSL4 gene in cataract formation in livestock.
Editorial Material
Agriculture, Dairy & Animal Science
Joana G. P. Jacinto, Irene M. Hafliger, Christine F. Baes, Hinayah R. de Oliveira, Cord Drogemuller
Article
Agriculture, Dairy & Animal Science
Heidi Signer-Hasler, Lucas Casanova, Alex Barenco, Blaise Maitre, Alessandro Bagnato, Mario Vevey, Beate Berger, Mojca Simcic, Denis Boichon, Aurelien Capitan, Ivica Medugorac, Joern Bennewitz, Gabor Meszaros, Johann Soelkner, Cord Droegemueller, Christine Flury
Summary: We analyzed genome-wide SNP data from 18 local cattle breeds from the Alpine region to understand their population structure and identify genomic regions involved in positive selection. Different breeds like Evolener, Eringer, Valdostana Pezzata Nera, and Valdostana Castana showed distinct genetic differences compared to other Alpine breeds. We found selection signatures on chromosome 6 near genes related to coat color and body size, and identified 47 genome regions with ROH islands using high-density SNP data. The results provide insights into adaptation to the alpine environment and specific characteristics in local Alpine cattle breeds.
Article
Veterinary Sciences
Stephanie Scheemaeker, Marine Inglebert, Sylvie Daminet, Martina Dettwiler, Anna Letko, Cord Drogemuller, Martin Kessler, Richard Ducatelle, Sven Rottenberg, Miguel Campos
Summary: Organoid cultures were established as an in vitro model to study new treatments for canine medullary thyroid carcinoma (cMTC) and evaluate the effects of antitumor drugs on the viability of organoids.
VETERINARY AND COMPARATIVE ONCOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Dorothea Lindtke, Franz R. Seefried, Cord Drogemuller, Markus Neuditschko
Summary: In about 90% of multiple pregnancies in cattle, shared blood circulation between fetuses leads to genetic chimerism in peripheral blood, resulting in reduced reproductive performance. Low-pass sequencing data allows reliable screening for blood chimeras, but blood is not recommended for detecting germline variants. Our study identified 20 putative blood chimeras based on increased genome-wide heterozygosity, while routine SNP microarray data showed no evidence of chimerism and high levels of genotype discordance with sequencing data.
Article
Agriculture, Dairy & Animal Science
Joana G. P. Jacinto, Eliana Schiavon, Irene M. Hafliger, Patrizio Coin, Franz R. Seefried, Cord Drogemuller
Article
Agriculture, Dairy & Animal Science
Joana G. P. Jacinto, Eliana Schiavon, Irene M. Haefliger, Patrizio Coin, Franz R. Seefried, Cord Droegemueller
Article
Agriculture, Dairy & Animal Science
Joana G. P. Jacinto, Marilena Bolcato, Irene M. Haefliger, Anna Oevermann, Arcangelo Gentile, Cord Droegemueller
Summary: A 6-month-old Holstein heifer was diagnosed with epilepsy characterized by focal seizures progressing to generalized seizures. The seizure episodes included pre-ictal depression and vocalization, followed by ictal phase with eyelid spasms, tongue contractions, nodding, and abundant salivation, and then convulsive phase with bilateral tonic, clonic or tonic-clonic activity and loss of consciousness. Neuropathology revealed axonal degeneration and astrocytic hypertrophic gliosis in the brainstem. Whole genome sequencing identified a heterozygous splice-site variant in DYRK1B, suggesting its association with epilepsy in cattle.
Article
Agriculture, Dairy & Animal Science
Gabriela Rudd Garces, Anna Letko, Irene M. Haefliger, Jana Mueller, Christiane Herden, Anne Nesseler, Henrik Wagner, Martin J. Schmidt, Cord Droegemueller, Gesine Luehken
Summary: This study reported a rare early-onset neurodegenerative disorder characterized by microcephaly in purebred Kerry Hill sheep. A genetic variant in the MFSD2A gene, responsible for maintaining blood-brain barrier homeostasis and regulating brain lipogenesis, was identified as the cause. This is the first report of a spontaneous MFSD2A variant in domestic animals.
Article
Biotechnology & Applied Microbiology
Anna Letko, Franz Brulisauer, Irene M. Hafliger, Eilidh Corr, Sandra Scholes, Cord Drogemuller
Summary: Whole-genome sequencing revealed a homozygous loss-of-function variant in the TMCO6 gene responsible for early-onset progressive ataxia and motor neuron degeneration in North Country Cheviot lambs. The pathogenic 4 bp deletion in this gene leads to a 50% protein truncation and a presumed loss of TMCO6 function, resulting in the recessive form of motor neuron disease in sheep. This study provides a spontaneous animal model for TMCO6 and has implications for comparative neurodegenerative disease research.
Article
Veterinary Sciences
Joana G. P. Jacinto, Peter Wohlsein, Irene M. Haefliger, Michael Karl, Michael Pohlers, Lutz Plobner, Walter Gruenberg, Cord Droegemueller
Summary: This article reports a case of hepatic fibrinogen storage disease (HFSD) in a 5-month-old Wagyu calf. The disease is characterized by lethargy, dehydration, acidemia, and increased liver enzyme activities. Histologically, hepatocytes show distinct cytoplasmic inclusions with a ground-glass appearance, which do not stain with the periodic acid-Schiff (PAS) reaction. Whole-genome sequencing identified a deleterious homozygous missense variant in the DGKG gene, adding DGKG to the list of candidate genes for HFSD in other species.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Veterinary Sciences
Joana G. P. Jacinto, Leonore Bettina Kuchler, Laureen M. Peters, Elke van der Vekens, Corinne Gurtner, Franz R. Seefried, Mireille Meylan, Cord Drogemuller
Summary: This study describes a case of recessive MOCOS-associated xanthinuria type II in a Brown Swiss calf. The disease manifested as hoof overgrowth, rough coat, urine sediment, and pneumonia, and its genetic etiology was confirmed through genetic testing. Additionally, the prevalence of the deleterious allele in the Brown Swiss population was found to be low.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
K. Tan, O. O. Adeniyi, A. Letko, G. RuddGarces, E. Manz, H. Wagner, P. Zanolari, C. Drogemuller, G. Luhken
Summary: The aim of this study was to map genomic regions associated with the different fleece types of alpacas. Using SNP arrays, the researchers identified genome-wide significantly associated markers in the scaffold region of chromosome 16, which contains a cluster of keratin genes. This is the first study to use a species-specific SNP array to identify genomic regions associated with fleece type differences in alpacas.