Article
Biochemistry & Molecular Biology
Zehuan Liao, Han Lin Yeo, Siaw Wen Wong, Yan Zhao
Summary: Cellular senescence is a complex process affecting various biological processes, with characteristics including senescence-associated phenotype and cell cycle arrest. Persistent senescence is associated with aging pathologies, while transient senescence is linked to beneficial programs.
Review
Biochemistry & Molecular Biology
Erika Csekes, Lucia Rackova
Summary: This article discusses the impact of skin aging and cellular senescence on the skin, as well as the role of natural polyphenols in preventing and delaying aging. It also summarizes the latest research on the anti-senescent mechanisms of polyphenols.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Jing Yang, Mengmeng Liu, Dongchun Hong, Musheng Zeng, Xing Zhang
Summary: Cellular senescence in cancer presents a dual role, acting as both a preventative measure and a promoter of tumor development. Senescent cells contribute to oncogenesis through their secretory phenotype, both inhibiting tumor growth and creating an environment conducive to tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Fernanda Hernandez-Gonzalez, Rosa Faner, Mauricio Rojas, Alvar Agusti, Manuel Serrano, Jacobo Sellares
Summary: Fibrosing interstitial lung diseases are chronic and fatal lung diseases characterized by the irreversible accumulation of scar tissue in the lung tissue. Cellular senescence, defined as a cell fate decision caused by unrepairable cellular damage, plays an important role in the initiation and progression of pulmonary fibrosis, likely by promoting molecular and cellular changes in chronic fibrosing processes. Targeting cellular senescence may be a potential therapeutic approach for treating fibrosing ILDs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Minxue Jia, Khaled Sayed, Maria G. Kapetanaki, William Dion, Lorena Rosas, Saad Irfan, Eleanor Valenzi, Ana L. Mora, Robert A. Lafyatis, Mauricio Rojas, Bokai Zhu, Panayiotis V. Benos
Summary: The study of aging and its mechanisms, such as cellular senescence, has provided valuable insights into age-related pathologies. Through the analysis of transcriptional profiles, the lymphoid enhancer binding factor 1 (LEF1) has been identified as an important regulator of gene expression in lung cells, which is associated with aging and cellular senescence.
Review
Immunology
Dominique E. Martin, Blake L. Torrance, Laura Haynes, Jenna M. Bartley
Summary: Immunometabolism plays a crucial role in aging, affecting immune cell activation and effector functions through metabolic pathways. It has been found that aging can impact the networks controlling immune cell metabolism, but further research is needed to fully understand these effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Endocrinology & Metabolism
Allyson K. Palmer, Tamar Tchkonia, James L. Kirkland
Summary: Cellular senescence contributes to inflammation and metabolic dysfunction in aging and obesity. Targeting senescent cells or their products shows promise in improving metabolic function. Initial evidence suggests that senolytic drugs are effective in depleting senescent cells.
MOLECULAR METABOLISM
(2022)
Review
Immunology
Blake L. Torrance, Laura Haynes
Summary: Aging increases the risk of adverse outcomes following respiratory infections in older adults. Cellular senescence plays a crucial role in disrupting lung function and diminishing the ability to protect against pathogens. However, most vaccines do not effectively confer protection against respiratory infections in older adults.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jamil Nehme, Abdullah Altulea, Teodora Gheorghe, Marco Demaria
Summary: Evidence suggests that metabolism is a major regulator of aging and that dietary interventions and metabolic perturbations can extend health and lifespan. A common target for delaying aging is cellular senescence, which involves growth arrest and the activation of pro-inflammatory factors. This article summarizes current knowledge on carbohydrate, lipid, and protein metabolism and their role in regulating cellular senescence. It also discusses the potential of dietary interventions to prevent disease and extend healthy longevity by modulating senescence-associated phenotypes, and the need for personalized nutritional interventions based on individual health and age status.
BIOMEDICAL JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Veronica Marrella, Amanda Facoetti, Barbara Cassani
Summary: Cellular senescence is an irreversible cell cycle arrest and inflammatory secretion phenomenon that affects various tissues, including lymphoid tissue, leading to chronic inflammation and immune dysfunction. Persistent microbial challenge or pathogenic microorganisms may accelerate cellular aging and premature senescence of immune cells. Therapeutic strategies targeting cellular senescence may improve immune dysfunctions in the elderly and reduce susceptibility to infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Egan L. Choi, Negar Taheri, Abhishek Chandra, Yujiro Hayashi
Summary: Due to modern medical advancements, more people are living longer lives. However, this increased lifespan does not always correspond to improved health, and can lead to a rise in aging-related diseases. These diseases are often attributed to cellular senescence, which creates a proinflammatory environment suitable for tumor progression. This review focuses on the effects of cellular senescence on gastrointestinal aging, inflammation, and cancers, aiming to enhance our understanding of these processes for future therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Teresa Rubio-Tomas, Ascension Rueda-Robles, Julio Plaza-Diaz, Ana I. alvarez-Mercado
Summary: Adequate nutrition is crucial for immune homeostasis, but the rising incidence of obesity worldwide is linked to chronic inflammation and cellular senescence. Targeting senescence processes may provide a beneficial approach to combating obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Takeshi Uemura, Miki Matsunaga, Yuka Yokota, Koichi Takao, Takemitsu Furuchi
Summary: The aging of the global population has led to the need for effective anti-aging technologies supported by scientific evidence. Polyamines, such as putrescine, spermidine, and spermine, play crucial roles in cell growth and function. This study investigated the relationship between increased expression of spermine oxidase (SMOX) and cellular senescence, using human-liver-derived HepG2 cells. The results suggest that SMOX-mediated degradation of spermine plays a pivotal role in cellular senescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Sacco, Laura Belloni, Lucia Latella
Summary: Senescence is a cellular state induced by internal or external stimuli, resulting in cell cycle arrest, morphological changes, and dysfunctions in mitochondrial and lysosomal functionality. Recent evidence suggests that senescent cells in vivo are a heterogeneous cell population due to different activated pathways and distinct microenvironmental contexts. Future research will focus on exploring the heterogeneity of senescent cells to map cell progression and study the therapeutic advantages of senolytic drugs.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biology
Sijia Chen, Dian Zhou, Ousheng Liu, Huan Chen, Yuehong Wang, Yueying Zhou
Summary: Oral health plays a crucial role in overall health, and tooth loss is closely associated with aging and periodontitis. Targeting cellular senescence may offer potential therapeutic strategies for age-related conditions, including tooth loss. This review explores the role of cellular senescence in oral health and discusses potential treatment options for excessive alveolar bone loss in periodontitis.
