Article
Pharmacology & Pharmacy
Huan Liu, Yuting Hu, Baoyu Qi, Chengqiu Yan, Lin Wang, Yiwen Zhang, Liang Chen
Summary: This study investigated the mechanism of Pulsatilla decoction (PD) in the treatment of colon cancer using network pharmacology and molecular docking. The results showed that PD may exert its effect through multi-components, multi-targets, and multi-pathways, involving cell proliferation, apoptosis, energy metabolism, immune regulation, and signal transduction. This study deepens our understanding of the potential mechanisms of PD in treating colon cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Haizhao Liu, Min Cao, Yutong Jin, Beitian Jia, Liming Wang, Mengxue Dong, Lu Han, Joseph Abankwah, Jianwei Liu, Tao Zhou, Baogui Chen, Yiyang Wang, Yuhong Bian
Summary: This study used a network pharmacology approach to characterize the mechanism of action of Bushen Huashi decoction (BSHS) in kidney stone disease. The experimental results showed that BSHS can reduce renal crystal deposition, improve renal function, decrease oxidative stress levels, and inhibit renal tubular epithelial cell apoptosis. The study also revealed that BSHS regulates the E2/ESR1/2, NRF2/HO-1, and BCL2/BAX signaling pathways in treating kidney stone disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Siqi Huang, Manying Qu, Xiaowu Chen, Shaochen Yu, Fanhua Kong
Summary: In this study, we explored the bioactive components, potential targets, and molecular mechanisms of Pulsatilla decoction (PD) in the treatment of gastric cancer (GC). Network pharmacological analysis identified 346 compounds and 180 potential target genes associated with the impact of PD on GC. The results showed that PD can inhibit proliferation, induce apoptosis, and exert cytotoxic effects on GC cells through the PI3K-AKT, IL-17, and TNF signaling pathways.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Medicinal
Huihao Zhang, Sai Yao, Zhiguo Zhang, Chengcong Zhou, Fangda Fu, Yishan Bian, Huan Luo, Yan Li, Shuxin Yan, Yuying Ge, Yuying Chen, Kunyu Zhan, Yanzhi Ge, Zuxiang Chen, Ming Yue, Xiaofeng Li, Weibin Du, Hongting Jin, Peijian Tong, Hongfeng Ruan, Chengliang Wu
Summary: Through network pharmacology analysis, the key targets and pathways of LWDHD in treating IVDD were verified, with animal experiments showing that LWDHD not only restored the disc height reduction and abnormal matrix metabolism degradation in IVDD mice, but also inhibited apoptosis and ameliorated the progression of IVDD.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Plant Sciences
Lin Wang, Xiulan Pu, Xin Nie, Di Wang, Huajuan Jiang, Yi Chen, Lan Pang, Shengju Wang, Xiao Wang, Zhiyi Xu, Chaomei Fu, Dasheng Lin, Jinming Zhang
Summary: This study identified bioactive compounds and potential mechanisms for a traditional Chinese medicine formula by integrating serum pharmacochemistry and network pharmacology. The results suggested the feasibility of this integrated strategy for studying the therapeutic effects of herbal remedies.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jinxia Yuan, Fei Yan, Wei Li, Guoliang Yuan
Summary: In this study, the effect of Xuefu Zhuyu Decoction on atherosclerosis was evaluated using a network pharmacological approach. The results showed that Xuefu Zhuyu Decoction has multiple components and targets, indicating its potential in treating atherosclerosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guishu Wang, Bo Zhou, Zheyi Wang, Yufeng Meng, Yaqian Liu, Xiaoqin Yao, Cuiling Feng
Summary: This study used network pharmacology approach to predict the active components and molecular mechanism of MGMD in treating asthma, showing that MGMD mainly prevents asthma through regulation of IL-4 and IL-13 signaling and the specialized pro-resolving mediators (SPMs) biosynthesis to inhibit airway inflammation and remodeling.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Integrative & Complementary Medicine
Biting Wang, Zengrui Wu, Weihua Li, Guixia Liu, Yun Tang
Summary: This study elucidated the mechanism of action of Huangqi decoction (HQD) on liver fibrosis by analyzing metabolomics data, network pharmacology, and molecular docking methods. Eight compounds and eight targets were identified to contribute to the effects of HQD on liver fibrosis through five signaling pathways. This research provides a new perspective for understanding the mechanism of action of Chinese herbal medicine.
Review
Integrative & Complementary Medicine
Jinmiao Zhong, Lihua Tan, Meiwan Chen, Chengwei He
Summary: This article reviews the pharmacological activities of Pulsatilla saponins (PS) and discusses the cellular or molecular mechanisms that mediate their multiple activities, such as inducing cancer cell apoptosis, inhibiting tumor angiogenesis, and protecting organs via anti-inflammatory and antioxidant measures. It aims to provide a comprehensive analysis and summary of research progress and future prospects in this field to facilitate further study and drug discovery of PS.
Article
Pharmacology & Pharmacy
Fan Wang, Siyuan Wang, Jing Wang, Kai Huang, Gaofeng Chen, Yuan Peng, Chenghai Liu, Yanyan Tao
Summary: This study used network pharmacological analysis and in vivo experiments to confirm the mechanisms of FZHY on renal fibrosis. The results showed that FZHY can exert anti-renal fibrosis effects by improving kidney function and reducing inflammatory factors, thereby inhibiting fibrosis-related signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yingying Yang, Lu Ding, Tingting Bao, Yaxin Li, Jing Ma, Qingwei Li, Zezheng Gao, Siyu Song, Jing Wang, Jiachao Zhao, Ziyuan Wang, Daqing Zhao, Xiangyan Li, Zeyu Wang, Linhua Zhao, Xiaolin Tong
Summary: Research has shown that Qimai Feiluoping decoction (QM) can improve PF symptoms in COVID-19 convalescent patients by regulating epithelial-mesenchymal transition, extracellular matrix degradation, and the TGF-beta signaling pathway. QM contains multiple active components and exerts its anti-PF effects by inhibiting the TGF-beta/Smad3 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Siliang Wang, Cheng Tang, Heng Zhao, Peiliang Shen, Chao Lin, Yun Zhu, Dan Han
Summary: SNS effectively impedes liver fibrosis progression by alleviating inflammation, ECM accumulation, aberrant angiogenesis, and apoptosis of hepatic parenchymal cells, along with inhibiting activation of hepatic stellate cells.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yuanyuan Zhong, Lingli Hu, Wenjing Chen, Bin Wang, Jing Sun, Jingcheng Dong
Summary: The study identified common therapeutic targets for asthma and IPF, with many overlapping proteins falling into the same statistically significant GO terms. The active ingredients of BSYQ decoction were found to regulate common pathological processes in asthma and IPF, such as inflammation response, cytokine production, leukocyte differentiation, and oxygen level response.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Pharmacology & Pharmacy
Ao Du, Yumin Xie, Hao Ouyang, Bin Lu, Wangya Jia, Hong Xu, Lili Ji
Summary: Si-Miao-Yong-An decoction (SMYAD) has a protective effect against diabetic retinopathy (DR) by suppressing retinal inflammation and promoting angiogenesis through abrogating NF-kappa B-TNF alpha and HIF1 alpha-VEGF signal pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Li-ying Jia, Gui-yun Cao, Jia Li, Lu Gan, Jin-xin Li, Xin-yi Lan, Zhao-qing Meng, Xin He, Chun-feng Zhang, Chong-Zhi Wang, Chun-Su Yuan
Summary: The study investigated the pharmacological mechanisms of SheXiang XinTongNing (XTN) against coronary heart disease using network pharmacology and experimental evaluation. Results indicated that XTN's potential mechanism against CHD is predominantly associated with cell apoptosis, effectively protecting the heart from oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2021)