标题
TGF-β/Smad Signaling Pathway in Tubulointerstitial Fibrosis
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 13, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2022-03-29
DOI
10.3389/fphar.2022.860588
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Nur77 ameliorates age‐related renal tubulointerstitial fibrosis by suppressing the TGF‐β/Smads signaling pathway
- (2022) Guojing Ma et al. FASEB JOURNAL
- Long non-coding RNAs: a double-edged sword in aging kidney and renal disease
- (2021) Yan-Ni Wang et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Negative regulators of TGF-β1 signaling in renal fibrosis; pathological mechanisms and novel therapeutic opportunities
- (2021) Cody C. Gifford et al. CLINICAL SCIENCE
- Poricoic acid A suppresses TGF‑β1‑induced renal fibrosis and proliferation via the PDGF‑C, Smad3 and MAPK pathways
- (2021) Qiang Li et al. Experimental and Therapeutic Medicine
- Long Non-Coding RNA 554 Promotes Cardiac Fibrosis via TGF-β1 Pathway in Mice Following Myocardial Infarction
- (2021) Bihui Luo et al. Frontiers in Pharmacology
- Cilomilast Ameliorates Renal Tubulointerstitial Fibrosis by Inhibiting the TGF-β1-Smad2/3 Signaling Pathway
- (2021) Man Xu et al. Frontiers in Medicine
- Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies
- (2021) Yao Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Bupi Yishen Formula Versus Losartan for Non-Diabetic Stage 4 Chronic Kidney Disease: A Randomized Controlled Trial
- (2021) Wei Mao et al. Frontiers in Pharmacology
- The Dysregulation of Eicosanoids and Bile Acids Correlates with Impaired Kidney Function and Renal Fibrosis in Chronic Renal Failure
- (2021) Yan-Ni Wang et al. Metabolites
- Uraemic solutes as therapeutic targets in CKD-associated cardiovascular disease
- (2021) Jonathan D. Ravid et al. Nature Reviews Nephrology
- Jian-Pi-Yi-Shen Formula Ameliorates Oxidative Stress, Inflammation, and Apoptosis by Activating the Nrf2 Signaling in 5/6 Nephrectomized Rats
- (2021) Fanyuan Zhou et al. Frontiers in Pharmacology
- Applications of Herbal Medicine to Treat Autosomal Dominant Polycystic Kidney Disease
- (2021) Guangying Shao et al. Frontiers in Pharmacology
- Mitochondrial Targeting of Herbal Medicine in Chronic Kidney Disease
- (2021) Qing Li et al. Frontiers in Pharmacology
- 1‐Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway
- (2021) Hua Miao et al. BRITISH JOURNAL OF PHARMACOLOGY
- Drug-containing serum of rhubarb-astragalus capsule inhibits the epithelial-mesenchymal transformation of HK-2 by downregulating TGF-β1/p38MAPK/Smad2/3 pathway
- (2021) Meng-yuan Qin et al. JOURNAL OF ETHNOPHARMACOLOGY
- Shenkang Injection and Its Three Anthraquinones Ameliorates Renal Fibrosis by Simultaneous Targeting IƙB/NF-ƙB and Keap1/Nrf2 Signaling Pathways
- (2021) Liang-Pu Luo et al. Frontiers in Pharmacology
- New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
- (2021) Minghai Shao et al. Frontiers in Pharmacology
- Smad4 promotes diabetic nephropathy by modulating glycolysis and OXPHOS
- (2020) Jinhua Li et al. EMBO REPORTS
- Rhubarb and Astragalus Capsule Attenuates Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction by Alleviating Apoptosis through Regulating Transforming Growth Factor beta1 (TGF-β1)/p38 Mitogen-Activated Protein Kinases (p38 MAPK) Pathway
- (2020) Xian Zeng et al. MEDICAL SCIENCE MONITOR
- Diverse Role of TGF-β in Kidney Disease
- (2020) Yue-Yu Gu et al. Frontiers in Cell and Developmental Biology
- Identification of endogenous 1‐aminopyrene as a novel mediator of progressive chronic kidney disease via aryl hydrocarbon receptor activation
- (2020) Hua Miao et al. BRITISH JOURNAL OF PHARMACOLOGY
- Astragalus polysaccharides protect renal function and affect the TGF-β/Smad signaling pathway in streptozotocin-induced diabetic rats
- (2020) Xue Meng et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019
- (2020) David J. Newman et al. JOURNAL OF NATURAL PRODUCTS
- Long Non-Coding RNA (LncRNA)-ATB Promotes Inflammation, Cell Apoptosis and Senescence in Transforming Growth Factor-β1 (TGF-β1) Induced Human Kidney 2 (HK-2) Cells via TGFβ/SMAD2/3 Signaling Pathway
- (2020) Han Sun et al. MEDICAL SCIENCE MONITOR
- Wnt signaling pathway in aging-related tissue fibrosis and therapies
- (2020) He-He Hu et al. AGEING RESEARCH REVIEWS
- Poricoic acid A activates AMPK to attenuate fibroblast activation and abnormal extracellular matrix remodelling in renal fibrosis
- (2020) Dan-Qian Chen et al. PHYTOMEDICINE
- Chrysophanol ameliorates renal interstitial fibrosis by inhibiting the TGF-β/Smad signaling pathway
- (2020) Fang Dou et al. BIOCHEMICAL PHARMACOLOGY
- Gut microbiota-derived tryptophan metabolism mediates renal fibrosis by aryl hydrocarbon receptor signaling activation
- (2020) Jing-Ru Liu et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Deciphering the cellular mechanisms underlying fibrosis-associated diseases and therapeutic avenues
- (2020) Hua Miao et al. PHARMACOLOGICAL RESEARCH
- Novel poricoic acids attenuate renal fibrosis through regulating redox signalling and aryl hydrocarbon receptor activation
- (2020) Ming Wang et al. PHYTOMEDICINE
- Macrophages: versatile players in renal inflammation and fibrosis
- (2019) Patrick Ming-Kuen Tang et al. Nature Reviews Nephrology
- The Matrix Metalloproteinase‐13 Inhibitor Poricoic Acid ZI Ameliorates Renal Fibrosis by Mitigating Epithelial‐Mesenchymal Transition
- (2019) Lin Chen et al. MOLECULAR NUTRITION & FOOD RESEARCH
- Activated NF-κB/Nrf2 and Wnt/β-catenin pathways are associated with lipid metabolism in CKD patients with microalbuminuria and macroalbuminuria
- (2019) Ya-Long Feng et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- LRNA9884, a Novel Smad3-Dependent LncRNA, Promotes Diabetic Kidney Injury in db/db Mice Via Enhancing MCP-1-Dependent Renal Inflammation
- (2019) Ying-ying Zhang et al. DIABETES
- Poricoic acid A enhances melatonin inhibition of AKI-to-CKD transition by regulating Gas6/Axl NF κB/Nrf2 axis
- (2019) Dan-Qian Chen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Small molecule inhibitors of epithelial‐mesenchymal transition for the treatment of cancer and fibrosis
- (2019) Ya‐Long Feng et al. MEDICINAL RESEARCH REVIEWS
- Klotho Inhibits Unilateral Ureteral Obstruction-Induced Endothelial-to-Mesenchymal Transition via TGF-β1/Smad2/Snail1 Signaling in Mice
- (2019) Shasha Li et al. Frontiers in Pharmacology
- Microbiome–metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease
- (2019) Ya-Long Feng et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation
- (2019) Min-Kyun Song et al. FREE RADICAL BIOLOGY AND MEDICINE
- Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology
- (2019) Tiantian Zhao et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Identification of serum metabolites associating with chronic kidney disease progression and anti-fibrotic effect of 5-methoxytryptophan
- (2019) Dan-Qian Chen et al. Nature Communications
- Combined Blockade of Smad3 and JNK Pathways Ameliorates Progressive Fibrosis in Folic Acid Nephropathy
- (2019) Mengjie Jiang et al. Frontiers in Pharmacology
- Chinese Herbal Medicine Ameliorated the Development of Chronic Kidney Disease in Patients with Chronic Hepatitis C: A Retrospective Population-Based Cohort Study
- (2019) Che-Pin Chang et al. Evidence-based Complementary and Alternative Medicine
- Tripterygium and its extracts for diabetic nephropathy: Efficacy and pharmacological mechanisms
- (2019) Wei-jun Huang et al. BIOMEDICINE & PHARMACOTHERAPY
- Triptolide inhibits PDGF-induced proliferation of ASMCs through G0/G1 cell cycle arrest and suppression of the AKT/NF-κB/cyclinD1 signaling pathway
- (2019) Siyun He et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Deletion of Smad3 prevents renal fibrosis and inflammation in type 2 diabetic nephropathy
- (2019) Bi-Hua Xu et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Mechanisms of Renal Fibrosis
- (2018) Benjamin D. Humphreys Annual Review of Physiology
- Central role of dysregulation of TGF-β/Smad in CKD progression and potential targets of its treatment
- (2018) Lin Chen et al. BIOMEDICINE & PHARMACOTHERAPY
- Novel inhibitors of the cellular renin-angiotensin system components, poricoic acids, target Smad3 phosphorylation and Wnt/β-catenin pathway against renal fibrosis
- (2018) Ming Wang et al. BRITISH JOURNAL OF PHARMACOLOGY
- New insights into TGF-β/Smad signaling in tissue fibrosis
- (2018) He-He Hu et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Novel RAS Inhibitors Poricoic Acid ZG and Poricoic Acid ZH Attenuate Renal Fibrosis via a Wnt/β-Catenin Pathway and Targeted Phosphorylation of smad3 Signaling
- (2018) Ming Wang et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Protective effects of Salvia miltiorrhiza on adenine-induced chronic renal failure by regulating the metabolic profiling and modulating the NADPH oxidase/ROS/ERK and TGF- β /Smad signaling pathways
- (2018) Hongdie Cai et al. JOURNAL OF ETHNOPHARMACOLOGY
- TGF-β Mediates Renal Fibrosis via the Smad3-Erbb4-IR Long Noncoding RNA Axis
- (2018) Min Feng et al. MOLECULAR THERAPY
- Novel RAS inhibitor 25-O-methylalisol F attenuates epithelial-to-mesenchymal transition and tubulo-interstitial fibrosis by selectively inhibiting TGF-β-mediated Smad3 phosphorylation
- (2018) Hua Chen et al. PHYTOMEDICINE
- Celastrol alleviates renal fibrosis by upregulating cannabinoid receptor 2 expression
- (2018) Ming Tang et al. Cell Death & Disease
- An Integrated Lipidomics and Phenotype Study Reveals Protective Effect and Biochemical Mechanism of Traditionally Used Alisma orientale Juzepzuk in Chronic Kidney Disease
- (2018) Fang Dou et al. Frontiers in Pharmacology
- The novel regulatory role of lncRNA-miRNA-mRNA axis in cardiovascular diseases
- (2018) Ying Huang JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- Natural products for the prevention and treatment of kidney disease
- (2018) Dan-Qian Chen et al. PHYTOMEDICINE
- Natural Products as a Source for Antifibrosis Therapy
- (2018) Dan-Qian Chen et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Rhubarb Protect Against Tubulointerstitial Fibrosis by Inhibiting TGF-β/Smad Pathway and Improving Abnormal Metabolome in Chronic Kidney Disease
- (2018) Zhi-Hao Zhang et al. Frontiers in Pharmacology
- Early growth response protein 1 upregulates long noncoding RNA Arid2-IR to promote extracellular matrix production in diabetic kidney disease
- (2018) Yan-Lin Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway
- (2018) Peng Wang et al. Science Translational Medicine
- Shenqiwan Ameliorates Renal Fibrosis in Rats by Inhibiting TGF-β1/Smads Signaling Pathway
- (2017) Hongshu Chen et al. Evidence-based Complementary and Alternative Medicine
- Deletion of Angiotensin-Converting Enzyme-2 Promotes Hypertensive Nephropathy by Targeting Smad7 for Ubiquitin DegradationNovelty and Significance
- (2017) Zhen Liu et al. HYPERTENSION
- Emodin ameliorates renal fibrosis in rats via TGF-β1/Smad signaling pathway and function study of Smurf 2
- (2017) Libin Ma et al. INTERNATIONAL UROLOGY AND NEPHROLOGY
- Chronic Kidney Disease
- (2017) Angela C Webster et al. LANCET
- Baicalin ameliorates renal fibrosis via inhibition of transforming growth factor β1 production and downstream signal transduction
- (2017) Long Zheng et al. Molecular Medicine Reports
- Poricoic acid ZA, a novel RAS inhibitor, attenuates tubulo-interstitial fibrosis and podocyte injury by inhibiting TGF-β/Smad signaling pathway
- (2017) Ming Wang et al. PHYTOMEDICINE
- Baicalin and baicalein attenuate renal fibrosis in vitro via inhibition of the TGF-β1 signaling pathway
- (2017) Qin Hu et al. Experimental and Therapeutic Medicine
- Effect of ligustrazine on preventing contrast-induced nephropathy in patients with unstable angina
- (2017) Ziliang Ye et al. Oncotarget
- Disease-syndrome combination modeling: metabolomic strategy for the pathogenesis of chronic kidney disease
- (2017) Shasha Li et al. Scientific Reports
- Advances in bio-active constituents, pharmacology and clinical applications of rhubarb
- (2017) Yu-Jie Cao et al. Chinese Medicine
- Gene and protein expressions and metabolomics exhibit activated redox signaling and wnt/β-catenin pathway are associated with metabolite dysfunction in patients with chronic kidney disease
- (2017) Dan-Qian Chen et al. Redox Biology
- Urinary biomarker and treatment mechanism of Rhizoma Alismatis on hyperlipidemia
- (2016) Hua Miao et al. BIOMEDICAL CHROMATOGRAPHY
- HuangQi Decoction Ameliorates Renal Fibrosis via TGF-β/Smad Signaling Pathway In Vivo and In Vitro
- (2016) Jie Zhao et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Anti-fibrotic effect of wogonin in renal tubular epithelial cells via Smad3-dependent mechanisms
- (2016) Xiao-Ming Meng et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Traditional uses, fermentation, phytochemistry and pharmacology of Phellinus linteus : A review
- (2016) Hua Chen et al. FITOTERAPIA
- TGF-β: the master regulator of fibrosis
- (2016) Xiao-ming Meng et al. Nature Reviews Nephrology
- Urinary active transforming growth factor β in feline chronic kidney disease
- (2016) J.S. Lawson et al. VETERINARY JOURNAL
- Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression
- (2016) Hua Chen et al. Redox Biology
- Global Prevalence of Chronic Kidney Disease – A Systematic Review and Meta-Analysis
- (2016) Nathan R. Hill et al. PLoS One
- An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure
- (2016) Zhi-Hao Zhang et al. Scientific Reports
- Urine metabolomics reveals new insights into hyperlipidemia and the therapeutic effect of rhubarb
- (2015) Hua Chen et al. Analytical Methods
- Protective Effect of Triptolide against Glomerular Mesangial Cell Proliferation and Glomerular Fibrosis in Rats Involves the TGF-β1/Smad Signaling Pathway
- (2015) Yingjie Cao et al. Evidence-based Complementary and Alternative Medicine
- You-gui Pill ameliorates renal tubulointerstitial fibrosis via inhibition of TGF-β/Smad signaling pathway
- (2015) Li Wang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Therapeutic targets for treating fibrotic kidney diseases
- (2015) So-Young Lee et al. Translational Research
- Structural determinants of Smad function in TGF-β signaling
- (2015) Maria J. Macias et al. TRENDS IN BIOCHEMICAL SCIENCES
- Metabolomics insights into chronic kidney disease and modulatory effect of rhubarb against tubulointerstitial fibrosis
- (2015) Zhi-Hao Zhang et al. Scientific Reports
- TGF-β/Smad signaling in renal fibrosis
- (2015) Xiao-Ming Meng et al. Frontiers in Physiology
- Protective Role of Oryeongsan Against Renal Inflammation and Glomerulosclerosis in db/db Mice
- (2014) Jung Joo Yoon et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- Effects of astragalus injection on the TGFβ/Smad pathway in the kidney in type 2 diabetic mice
- (2014) Yanna Nie et al. BMC Complementary and Alternative Medicine
- Expression of miR-106b-25 induced by salvianolic acid B inhibits epithelial-to-mesenchymal transition in HK-2 cells
- (2014) Qiong Tang et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro
- (2014) Li Wang et al. EXPERIMENTAL BIOLOGY AND MEDICINE
- Ureic clearance granule, alleviates renal dysfunction and tubulointerstitial fibrosis by promoting extracellular matrix degradation in renal failure rats, compared with enalapril
- (2014) Yan-Ru Huang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Diuretic and anti-diuretic activities of the ethanol and aqueous extracts of Alismatis rhizoma
- (2014) Ya-Long Feng et al. JOURNAL OF ETHNOPHARMACOLOGY
- Diuretic and anti-diuretic activities of fractions of Alismatis rhizoma
- (2014) Dan-Qian Chen et al. JOURNAL OF ETHNOPHARMACOLOGY
- Traditional uses, phytochemistry, pharmacology, toxicology and quality control of Alisma orientale (Sam.) Juzep: A review
- (2014) Ting Tian et al. JOURNAL OF ETHNOPHARMACOLOGY
- siRNAs targeted to Smad4 prevent renal fibrosis in vivo
- (2014) Yoshiyuki Morishita et al. Scientific Reports
- Diuretic activity of some fractions of the epidermis of Poria cocos
- (2013) Ya-Long Feng et al. JOURNAL OF ETHNOPHARMACOLOGY
- Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury in rats
- (2013) Ying-Yong Zhao et al. JOURNAL OF ETHNOPHARMACOLOGY
- Mycology, cultivation, traditional uses, phytochemistry and pharmacology of Wolfiporia cocos (Schwein.) Ryvarden et Gilb.: A review
- (2013) Yuan-Zhong Wang et al. JOURNAL OF ETHNOPHARMACOLOGY
- Low-dose of multi-glycoside of Tripterygium wilfordii Hook. f., a natural regulator of TGF-β1/Smad signaling activity improves adriamycin-induced glomerulosclerosis in vivo
- (2013) Yi-Gang Wan et al. JOURNAL OF ETHNOPHARMACOLOGY
- Renal metabolic profiling of early renal injury and renoprotective effects of Poria cocos epidermis using UPLC Q-TOF/HSMS/MSE
- (2013) Ying-Yong Zhao et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Contribution of genetics and epigenetics to progression of kidney fibrosis
- (2013) B. Tampe et al. NEPHROLOGY DIALYSIS TRANSPLANTATION
- Ultra Performance Liquid Chromatography-Based Metabonomic Study of Therapeutic Effect of the Surface Layer of Poria cocos on Adenine-Induced Chronic Kidney Disease Provides New Insight into Anti-Fibrosis Mechanism
- (2013) Ying-Yong Zhao et al. PLoS One
- Meta-Analysis of the Clinical Effect of Ligustrazine on Diabetic Nephropathy
- (2012) Bin Wang et al. AMERICAN JOURNAL OF CHINESE MEDICINE
- Role of the TGF-β/BMP-7/Smad pathways in renal diseases
- (2012) Xiao-Ming Meng et al. CLINICAL SCIENCE
- Diverse Roles of TGF-β/Smads in Renal Fibrosis and Inflammation
- (2012) Hui Yao Lan International Journal of Biological Sciences
- Diuretic activity of the ethanol and aqueous extracts of the surface layer of Poria cocos in rat
- (2012) Ying-Yong Zhao et al. JOURNAL OF ETHNOPHARMACOLOGY
- Diverse roles of TGF-β receptor II in renal fibrosis and inflammation in vivo and in vitro
- (2011) Xiao-Ming Meng et al. JOURNAL OF PATHOLOGY
- Ergosta-4,6,8(14),22-tetraen-3-one isolated fromPolyporus umbellatusprevents early renal injury in aristolochic acid-induced nephropathy rats
- (2011) Ying-Yong Zhao et al. JOURNAL OF PHARMACY AND PHARMACOLOGY
- Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro
- (2011) Xiao-Ming Meng et al. KIDNEY INTERNATIONAL
- Effects of tanshinone IIA on transforming growth factor β1-Smads signal pathway in renal interstitial fibroblasts of rats
- (2010) Jinhui Tang et al. Journal of Huazhong University of Science and Technology-Medical Sciences
- Smad2 Protects against TGF- /Smad3-Mediated Renal Fibrosis
- (2010) X. M. Meng et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started