Article
Cardiac & Cardiovascular Systems
Marina Urena, Alec Vahanian, Eric Brochet, Gregory Ducrocq, Bernard Iung, Dominique Himbert
Summary: The clinical use of TMVR using transcatheter aortic valves is limited to patients with failing bioprostheses or rings, and mitral valve disease associated with severe mitral annulus calcification. While valve-in-valve TMVR seems to be a reasonable alternative to surgery for high-risk patients, there is less evidence supporting valve-in-ring and valve-in-mitral annulus calcification interventions.
Article
Cardiac & Cardiovascular Systems
Natalie Glaser, Veronica Jackson, Per Eriksson, Ulrik Sartipy, Anders Franco-Cereceda
Summary: The study aimed to analyze long-term survival in patients with Bicuspid Aortic Valve (BAV) who underwent aortic valve surgery. Results showed that the survival of BAV patients following surgery was excellent and similar to the general population, with slightly lower survival rates for women compared to men. These findings suggest that the timing of surgery according to current guidelines is appropriate and provide valuable information about the natural history of BAV in patients post-aortic valve surgery.
Article
Cardiac & Cardiovascular Systems
Edward D. Percy, Morgan Harloff, Sameer Hirji, Alexandra Malarczyk, Olena Cherkasky, Farhang Yazdchi, Siobhan McGurk, Prem Shekar, Tsuyoshi Kaneko
Summary: Subclinical SVD occurred in a large proportion of young patients undergoing bioprosthetic SAVR, but was not associated with decreased survival or repeat procedures.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Zachary Tugaoen, Peter Nguyen, Sameer Arora, John Vavalle
Summary: This review explores the characteristics of currently approved transcatheter heart valve systems and provides a simplified decision tree for selecting the optimal transcatheter valve system for specific patient-centered characteristics.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
John J. Squiers, N. Bryce Robinson, Katia Audisio, William H. Ryan, Michael J. Mack, Mohamed Rahouma, Gianmarco Cancelli, Hristo Kirov, Torsten Doenst, Mario Gaudino, J. Michael DiMaio
Summary: This study compared the rates of structural valve degeneration (SVD) following surgical aortic valve replacement with different bioprosthetic valves. The results showed that the ME valve had a lower SVD rate compared to the TF valve, but there was no significant difference between the TF valve and the Mitroflow valve. Additionally, the TF valve had higher rates of all-cause reintervention compared to the ME and Perimount valves.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Biophysics
Dimitrios P. Sokolis, Despoina Ch. Markidi, Dimitrios C. Iliopoulos, Stavros K. Kourkoulis
Summary: The stress distribution in ascending thoracic aortic aneurysms is determined by various factors. The study aimed to characterize the zero-stress state of the aneurysmal aorta in tricuspid and bicuspid aortic valve patients. The results showed similarities in the opening angles and residual stretches between the patient groups.
JOURNAL OF BIOMECHANICS
(2023)
Article
Cardiac & Cardiovascular Systems
Abigail White, Sabin J. Bozso, Olivia Lakey, Yongzhe Hong, Shaohua Wang, Jeevan Nagendran, Michael C. Moon
Summary: This study compared the outcomes of rapid deployment valves with conventional surgical aortic valve replacement and found that rapid deployment valves offered no benefit in straightforward aortic valve replacement. Further study is needed to determine which patient population the valve is suited for.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Michel Pompeu B. O. Sa, Matheus Simonato, Jef Van den Eynde, Luiz Rafael P. Cavalcanti, Leonardo Roever, Gianluigi Bisleri, Aleksander Dokollari, Danny Dvir, Konstantin Zhigalov, Arjang Ruhparwar, Alexander Weymann
Summary: TAVI has become a global reality for treating AS, offering a less invasive approach. Recent studies are exploring new indications for TAVI such as asymptomatic severe AS, bicuspid aortic valves, and moderate AS in heart failure patients.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Thorald Stolte, Jasper Boeddinghaus, Giampiero Allegra, Gregor Leibundgut, Oliver Reuthebuch, Christoph Kaiser, Christian Mueller, Thomas Nestelberger
Summary: This study highlights the increasing trend of valve-in-valve procedures for patients with aortic stenosis over the last decade. The results show that these interventions are feasible and result in lasting improvements in mean aortic valve gradients. There were no differences in technical and device successes or event-free survival between TAVR-in-SAVR and TAVR-in-TAVR.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Meng Zhao, Yihu Tang, Luo Li, Yawei Dai, Jieyu Lu, Xiang Liu, Jingxin Zhou, Yanhu Wu
Summary: Valvuloplasty for rheumatic aortic valve disease has been explored in this study, and it was found to be effective and safe for rheumatic patients. The analysis of data showed positive effects of valvuloplasty on the survival rate and reoperation rate of patients, but there was a degree of heterogeneity in the improvement of aortic insufficiency grade and valve gradient.
SCIENTIFIC REPORTS
(2022)
Review
Cardiac & Cardiovascular Systems
Giuseppe Tarantini, Danny Dvir, Gilbert H. L. Tang
Summary: Transcatheter aortic valve implantation (TAVI) within failed bioprosthetic surgical aortic valves (valve-in-valve TAVI) is a well-established procedure for high-risk patients needing repeat aortic valve intervention. Challenges in valve-in-valve treatment include malposition, prosthesis-patient mismatch, and coronary obstruction, highlighting the importance of optimal patient selection and preprocedural planning to minimize risks. This review article provides a comprehensive overview of key periprocedural considerations for valve-in-valve TAVI.
Review
Cardiac & Cardiovascular Systems
Giuseppe Tarantini, Janarthanan Sathananthan, Tommaso Fabris, Uri Landes, Vinayak N. Bapat, Jaffar M. Khan, Luca Nai Fovino, Syed Zaid, Nicolas M. Van Mieghem, Azeem Latib, Ron Waksman, Ole De Backer, Toby Rogers, Lars Sondergaard, Gilbert H. L. Tang
Summary: The article discusses the increasing use of TAVR in younger and lower surgical risk patients and the potential need for redo-TAVR in the future due to the longer life expectancy of these patients. It provides an overview of indications, procedural planning, implantation technique, and outcomes in failed transcatheter bioprosthetic aortic valves.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Testa, Mauro Agnifili, Nicolas M. Van Mieghem, Didier Tchetche, Anita W. Asgar, Ole De Backer, Azeem Latib, Bernhard Reimers, Giulio Stefanini, Carlo Trani, Antonio Colombo, Francesco Giannini, Antonio Bartorelli, Wojtek Wojakowski, Maciej Dabrowski, Dariusz Jagielak, Adrian P. Banning, Rajesh Kharbanda, Raul Moreno, Joachim Schofer, Niels van Royen, Duane Pinto, Antoni Serra, Amit Segev, Arturo Giordano, Nedy Brambilla, Antonio Popolo Rubbio, Matteo Casenghi, Jacopo Oreglia, Federico De Marco, Rudolph Tanja, James M. McCabe, Alexander Abizaid, Michiel Voskuil, Rui Teles, Giuseppe Biondi Zoccai, Giovanni Bianchi, Lars Sondergaard, Francesco Bedogni
Summary: The study demonstrated that patients with degenerated TAV treated with a second TAVR had favorable clinical outcomes, with low mortality rates and no significant difference in rates of new hospitalizations or New York Heart Association class. Follow-up at one year showed relatively low mortality and hospitalization rates.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Flavien Vincent, Julien Ternacle, Tom Denimal, Mylene Shen, Bjorn Redfors, Cedric Delhaye, Matheus Simonato, Nicolas Debry, Basile Verdier, Bahira Shahim, Thibault Pamart, Hugues Spillemaeker, Guillaume Schurtz, Francois Pontana, Vinod H. Thourani, Philippe Pibarot, Eric Van Belle
Summary: TAVR is rapidly expanding its indications, but faces technical challenges and knowledge gaps when dealing with patients with bicuspid aortic valve (BAV). Physicians need to understand the BAV anatomy and TAVR procedure planning comprehensively to guide treatment decisions.
Article
Biotechnology & Applied Microbiology
Roberta Scuoppo, Stefano Cannata, Giovanni Gentile, Caterina Gandolfo, Salvatore Pasta
Summary: This study used finite-element analysis to quantify coronary flow in a patient who underwent TAVR-in-TAVR and found that high implantation depth and device undersize of the second THV can significantly reduce coronary flow. Additionally, a positive correlation was observed between coronary flow and the valve-to-coronary distance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
A. H. Aly, E. K. Lai, N. Yushkevich, R. H. Stoffers, J. H. Gorman, A. T. Cheung, H. Gorman, R. C. Gorman, P. A. Yushkevich, A. M. Pouch
Summary: The study aims to accurately reconstruct cardiac valve morphology and motion through image analysis algorithms, providing personalized descriptions for cardiac patients and insights into disease pathophysiology. Results demonstrate that automated 4D image analysis allows for reliable modeling of mitral valve dynamics, facilitating research on pathological and normal valves.
EXPERIMENTAL MECHANICS
(2021)
Article
Biophysics
Alberto Coccarelli, Jason M. Carson, Ankush Aggarwal, Sanjay Pant
Summary: The study introduces a new framework for investigating the impact of vascular structure on arterial hemodynamics in the human common carotid artery. Geometrical factors were found to play a major role in influencing the blood flow dynamics of the vascular system, while different flow conditions and models did not significantly affect the hemodynamic variables.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carrie E. Zimmerman, Pulkit Khandelwal, Long Xie, Hyunyeol Lee, Hee Kwon Song, Paul A. Yushkevich, Arastoo Vossough, Scott P. Bartlett, Felix W. Wehrli
Summary: This study evaluated an automatic multi-atlas segmentation pipeline for cranial vault images, eliminating the need for manual intervention. The results showed good agreement between CT and automated MRI-based 3D cranial vault renderings, effectively eliminating the labor-intensive manual segmentation process.
ACADEMIC RADIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Alistair McQueen, Javier Escuer, Ankush Aggarwal, Simon Kennedy, Christopher McCormick, Keith Oldroyd, Sean McGinty
Summary: The introduction of drug-eluting stents (DES) has transformed the treatment of coronary artery disease, with a focus on improving patient outcomes through advancements in stent technology. Mathematical and computational modelling plays a key role in studying structural mechanics, computational fluid dynamics, drug elution kinetics, and binding within the arterial wall. However, there is a lack of models depicting the action of drugs on smooth muscle cell growth after stent deployment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Clinical Neurology
Paul A. Yushkevich, Monica Munoz Lopez, Maria Mercedes Iniguez de Onzono Martin, Ranjit Ittyerah, Sydney Lim, Sadhana Ravikumar, Madigan L. Bedard, Stephen Pickup, Weixia Liu, Jiancong Wang, Ling Yu Hung, Jade Lasserve, Nicolas Vergnet, Long Xie, Mengjin Dong, Salena Cui, Lauren McCollum, John L. Robinson, Theresa Schuck, Robin de Flores, Murray Grossman, M. Dylan Tisdall, Karthik Prabhakaran, Gabor Mizsei, Sandhitsu R. Das, Emilio Artacho-Perula, Mari'a Del Mar Arroyo Jimenez, Mari'a Pilar Marcos Raba, Francisco Javier Molina Romero, Sandra Cebada Sanchez, Jose Carlos Delgado Gonzalez, Carlos De la Rosa-Prieto, Marta Corcoles Parada, Edward B. Lee, John Q. Trojanowski, Daniel T. Ohm, Laura E. M. Wisse, David A. Wolk, David J. Irwin, Ricardo Insausti
Summary: This study utilized ex vivo MRI and dense serial histological imaging to construct three-dimensional quantitative maps of neurofibrillary tangle burden in the medial temporal lobe, revealing significant variation along different anatomical regions. The findings provide valuable insights into the distribution of this neurodegenerative pathology and may support the development and validation of neuroimaging biomarkers.
Article
Geriatrics & Gerontology
Laura Em Wisse, Long Xie, Sandhitsu R. Das, Robin de Flores, Oskar Hansson, Mohamad Habes, Jimit Doshi, Christos Davatzikos, Paul A. Yushkevich, David A. Wolk
Summary: The study found that CSF p-tau levels partially mediated the effect of age on hippocampal atrophy rates, while no significant associations were observed for WMHs with temporal lobe structural changes. These results suggest a potential role of tau pathology in age-related MTL structural changes.
NEUROBIOLOGY OF AGING
(2022)
Article
Engineering, Multidisciplinary
Li-Wei Liu, Chung-Hao Lee, Ankush Aggarwal, Chih-Ming Chao, Colton J. Ross, Yu-Kai Liao
Summary: The mechanical behavior of tricuspid valve chordae tendineae tissue is investigated in this study through experimental and theoretical approaches. The experimental results reveal the typical force-displacement curve of the tissue and a viscoelastic model is developed accordingly. The proposed model exhibits superior performance in creep and monotonic loading experiments.
APPLIED MATHEMATICAL MODELLING
(2022)
Article
Biology
Danni Tu, Manu S. Goyal, Jordan D. Dworkin, Samuel Kampondeni, Lorenna Vidal, Eric Biondo-Savin, Sandeep Juvvadi, Prashant Raghavan, Jennifer Nicholas, Karen Chetcuti, Kelly Clark, Timothy Robert-Fitzgerald, Theodore D. Satterthwaite, Paul Yushkevich, Christos Davatzikos, Guray Erus, Nicholas J. Tustison, Douglas G. Postels, Terrie E. Taylor, Dylan S. Small, Russell T. Shinohara
Summary: A central challenge in medical imaging studies is to extract biomarkers that can characterize disease pathology or outcomes. This paper presents a fully automated framework for translating radiological diagnostic criteria into image-based biomarkers, with excellent classification performance.
Article
Engineering, Multidisciplinary
Ankush Aggarwal, Bjorn Sand Jensen, Sanjay Pant, Chung-Hao Lee
Summary: Data-based approaches are a promising alternative to traditional analytical constitutive models for solid mechanics. This study proposes a Gaussian process-based constitutive modeling framework for planar, hyperelastic, and incompressible soft tissues. The strain energy density of soft tissues is modeled as a Gaussian process and can be regressed to experimental stress-strain data. The proposed framework can be trained with limited experimental data and provides a straightforward way of quantifying uncertainty in simulation-based predictions.
COMPUTER METHODS IN APPLIED MECHANICS AND ENGINEERING
(2023)
Article
Engineering, Biomedical
Ankush Aggarwal, Luke T. Hudson, Devin W. Laurence, Chung-Hao Lee, Sanjay Pant
Summary: A Bayesian approach was used to calculate the relative probabilities of different constitutive models for porcine aortic valve tissue based on experimental data. The May-Newman model was found to be the most probable model for the overall data, while the Lee-Sacks model and May-Newman model were equally probable for non-coronary cusps. The results demonstrate the ability of a PCA-based statistical model to capture significant variations in the mechanical properties of soft tissues.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Clinical Neurology
Claire Andre, Elizabeth Kuhn, Stephane Rehel, Valentin Ourry, Solene Demeilliez-Servouin, Cassandre Palix, Francesca Felisatti, Pierre Champetier, Sophie Dautricourt, Paul Yushkevich, Denis Vivien, Vincent de la Sayette, Gael Chetelat, Robin de Flores, Geraldine Rauchs, Medit Ageing Res Grp
Summary: This study aimed to investigate the association between sleep disordered breathing (SDB) and medial temporal lobe neurodegeneration, as well as subsequent episodic memory impairment. The study found that SDB was associated with reduced volumes of medial temporal lobe subregions in amyloid-positive individuals, but not in amyloid-negative individuals. Additionally, lower baseline volumes of the whole hippocampus and CA1 were associated with worse episodic memory performance at follow-up.
Article
Computer Science, Artificial Intelligence
Ankush Aggarwal, Peter Mortensen, Jilei Hao, Lukasz Kaczmarczyk, Albert T. Cheung, Lourdes Al Ghofaily, Robert C. Gorman, Nimesh D. Desai, Joseph E. Bavaria, Alison M. Pouch
Summary: In this study, a semi-automated method based on fully nonlinear shell-based kinematics was proposed to estimate strains from four-dimensional echocardiographic images and applied to the aortic roots of patients with normal trileaflet aortic valves (TAV) and congenital bicuspid aortic valves (BAV). The results showed that even for size-matched non-aneurysmal aortic roots, BAV patients experienced larger regional shear strains. This elevated strains might contribute to the higher risk of aneurysm development in BAV patients. The proposed framework is openly available and applicable to any tubular structures.
MEDICAL IMAGE ANALYSIS
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Conor Bradley, Ankush Aggarwal, Keith Goatman, Gareth Jones, Colin Berry, Richard Good
Meeting Abstract
Cardiac & Cardiovascular Systems
C. Bradley, A. Aggarwal, K. Goatman, G. Jones, C. Berry, R. Good
EUROPEAN HEART JOURNAL
(2021)
Article
Mathematics, Applied
Ankush Aggarwal, Damiano Lombardi, Sanjay Pant
Summary: The study proposes a new optimal design framework based on information-theoretic measures, tested on protocols for estimating hyperelastic model parameters in biaxial soft tissue experiments. Results indicate that lower angles have lower information content compared to higher angles, and fewer angles with appropriate combinations can lead to higher information gains.
Article
Biophysics
Nathan D. Camarillo, Rafael Jimenez-Silva, Frances T. Sheehan
Summary: This article discusses the statistical dependence between multiple measurements from the same participant and provides recommendations for using these measurements when they are not independent.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
J. Huet, A. -S. Boureau, A. Sarcher, C. Cornu, A. Nordez
Summary: Standard compression in freehand 3D ultrasound induces a bias in volume calculations, but minimal compression and gel pad methods have similar results. With a trained examiner and precautions, the bias can be minimized and become acceptable in clinical applications.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
C. Lariviere, A. H. Eskandari, H. Mecheri, F. Ghezelbash, D. Gagnon, A. Shirazi-Adl
Summary: Recent developments in musculoskeletal modeling have focused on model customization. Personalization of the spine profile may affect estimates of spinal loading and stability. This study investigates the biomechanical consequences of changes in the spinal profile and finds that personalizing the spine profile has medium to large effects on trunk muscle forces and negligible to small effects on spinal loading and stability.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Luke T. Mattar, Arash B. Mahboobin, Adam J. Popchak, William J. Anderst, Volker Musahl, James J. Irrgang, Richard E. Debski
Summary: Exercise therapy fails in about 25.0% of cases for individuals with rotator cuff tears, and one reason for this failure may be the inability to strengthen and balance the muscle forces that keep the humeral head in the correct position. This study developed computational musculoskeletal models to compare the net muscle force before and after exercise therapy between successfully and unsuccessfully treated patients. The study found that unsuccessfully treated patients had less inferiorly oriented net muscle forces, which may increase the risk of impingement.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Natsuki Sado, Takeshi Edagawa, Toshihide Fujimori, Shogo Hashimoto, Yoshikazu Okamoto, Takahito Nakajima
Summary: The existing methods for predicting hip and lumbosacral joint centres in Japanese adults are biased and differ between sexes. We propose new regression equations that consider soft-tissue thickness, sex differences, and a height-directional measure, and validate them using leave-one-out cross-validation.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Peimin Yu, Xuanzhen Cen, Qichang Mei, Alan Wang, Yaodong Gu, Justin Fernandez
Summary: This study aimed to explore the intra-foot biomechanical differences among individuals with chronic ankle instability (CAI), copers, and healthy individuals during dynamic tasks. The study found that copers and CAI individuals had smaller dorsiflexion angles and copers presented a more eversion position compared to healthy participants. Copers also had greater dorsiflexion angles in the metatarsophalangeal joint and more inversion moments in the subtalar joint during certain tasks. These findings can help in designing interventions to restore ankle joint functions in CAI individuals.
JOURNAL OF BIOMECHANICS
(2024)
Article
Biophysics
Jon Skovgaard Jensen, Anders Holsgaard-Larsen, Anders Stengaard Sorensen, Per Aagaard, Jens Bojsen-Moller
Summary: This study investigates the biomechanical effects of robot-assisted body weight unloading (BWU) on gait patterns in healthy young adults. The results show that dynamic robot-assisted BWU enables reduced kinetic requirements without distorting biomechanically normal gait patterns during overground walking.
JOURNAL OF BIOMECHANICS
(2024)