Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain

Proteomic Identification of Cysteine Cathepsin Substrates Shed from the Surface of Cancer Cells

(2015) Barbara Sobotič et al.   MOLECULAR & CELLULAR PROTEOMICS

Fast profiling of protease specificity reveals similar substrate specificities for cathepsins K, L and S

(2015) Matej Vizovišek et al.   PROTEOMICS

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

(2015) Vemuri B. Reddy et al.   Nature Communications

Kinetics and thermodynamics of metal binding to the N-terminus of a human copper transporter, hCTR1

(2013) Xiubo Du et al.   CHEMICAL COMMUNICATIONS

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain

(2013) H. Ohrvik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic cleavage of the disease-related lysosomal membrane glycoprotein CLN7

(2012) Pieter Steenhuis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Charting the travels of copper in eukaryotes from yeast to mammals

(2012) Tracy Nevitt et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Role of the Human High-Affinity Copper Transporter in Copper Homeostasis Regulation and Cisplatin Sensitivity in Cancer Chemotherapy

(2012) M. T. Kuo et al.   CANCER RESEARCH

Prediction of copper transport protein 1 (CTR1) genotype on severe cisplatin induced toxicity in non-small cell lung cancer (NSCLC) patients

(2012) Xiaojing Xu et al.   LUNG CANCER

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

(2012) A. Garcia-Cattaneo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted in renal carcinoma 2 (DIRC2), a novel transporter of the lysosomal membrane, is proteolytically processed by cathepsin L

(2011) Lalu Rudyat Telly Savalas et al.   BIOCHEMICAL JOURNAL

Specific functions of lysosomal proteases in endocytic and autophagic pathways

(2011) Sabrina Müller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cysteine cathepsins: From structure, function and regulation to new frontiers

(2011) Vito Turk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

(2011) T. Shree et al.   GENES & DEVELOPMENT

Prognostic value of the copper transporters, CTR1 and CTR2, in patients with ovarian carcinoma receiving platinum-based chemotherapy

(2011) Yoo-Young Lee et al.   GYNECOLOGIC ONCOLOGY

Model Peptides Provide New Insights into the Role of Histidine Residues as Potential Ligands in Human Cellular Copper Acquisition via Ctr1

(2011) Kathryn L. Haas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of the N-terminus of mammalian copper transporter 1 in the cellular accumulation of cisplatin

(2010) Christopher A. Larson et al.   BIOCHEMICAL PHARMACOLOGY

Ctr1 Is an Apical Copper Transporter in Mammalian Intestinal Epithelial Cellsin VivoThat Is Controlled at the Level of Protein Stability

(2010) Yasuhiro Nose et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wilson Disease at a Single Cell Level

(2010) Martina Ralle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of the Methionines and Histidines in the Transmembrane Domain of Mammalian Copper Transporter 1 in the Cellular Accumulation of Cisplatin

(2010) C. A. Larson et al.   MOLECULAR PHARMACOLOGY

Regulation of Copper Transporter 2 Expression by Copper and Cisplatin in Human Ovarian Carcinoma Cells

(2010) B. G. Blair et al.   MOLECULAR PHARMACOLOGY

Metabolic crossroads of iron and copper

(2010) James F Collins et al.   NUTRITION REVIEWS

Copper Transporter 2 Regulates the Cellular Accumulation and Cytotoxicity of Cisplatin and Carboplatin

(2009) B. G. Blair et al.   CLINICAL CANCER RESEARCH

Human Copper Transporter 1 LackingO-Linked Glycosylation Is Proteolytically Cleaved in a Rab9-positive Endosomal Compartment

(2009) Edward B. Maryon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper-dependent Recycling of hCTR1, the Human High Affinity Copper Transporter

(2009) Shannon A. Molloy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1

(2009) Sarah E. Crider et al.   Metallomics

Three-dimensional structure of the human copper transporter hCTR1

(2009) C. J. De Feo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

(2008) Elizabeth M. Duncan et al.   CELL

Major Role of Cathepsin L for Producing the Peptide Hormones ACTH, β-Endorphin, and α-MSH, Illustrated by Protease Gene Knockout and Expression

(2008) Lydiane Funkelstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitory Fragment from the p41 Form of Invariant Chain Can Regulate Activity of Cysteine Cathepsins in Antigen Presentation

(2008) Marko Mihelič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Proteolytic Processing of the Ectodomain of the Zinc Transporter ZIP4 (SLC39A4) during Zinc Deficiency Is Inhibited by Acrodermatitis Enteropathica Mutations

(2008) T. Kambe et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanisms for copper acquisition, distribution and regulation

(2008) Byung-Eun Kim et al.   Nature Chemical Biology