Tankyrase Inhibitor Sensitizes Lung Cancer Cells to Endothelial Growth Factor Receptor (EGFR) Inhibition via Stabilizing Angiomotins and Inhibiting YAP Signaling

Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer

(2015) Fa-Xing Yu et al.   CELL

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

(2015) Oren Parnas et al.   CELL

Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway

(2015) Youjun Li et al.   CELL RESEARCH

Estrogen regulates Hippo signaling via GPER in breast cancer

(2015) Xin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

(2015) Luping Lin et al.   NATURE GENETICS

High-throughput functional genomics using CRISPR–Cas9

(2015) Ophir Shalem et al.   NATURE REVIEWS GENETICS

Disease implications of the Hippo/YAP pathway

(2015) Steven W. Plouffe et al.   TRENDS IN MOLECULAR MEDICINE

Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins

(2015) Wenqi Wang et al.   Cell Reports

Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling

(2014) M. Schoumacher et al.   CANCER RESEARCH

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer

(2014) Avnish Kapoor et al.   CELL

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival

(2014) Diane D. Shao et al.   CELL

Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth

(2014) Nan Li et al.   GENES & DEVELOPMENT

Canonical WNT signaling components in vascular development and barrier formation

(2014) Yulian Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

(2014) Paul A. DaRosa et al.   NATURE

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

(2014) G. R. Hoffman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Energy Stress Regulates Hippo-YAP Signaling Involving AMPK-Mediated Regulation of Angiomotin-like 1 Protein

(2014) Michael DeRan et al.   Cell Reports

Proteasome Regulation by ADP-Ribosylation

(2013) Park F. Cho-Park et al.   CELL

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Tankyrases as drug targets

(2013) Lari Lehtiö et al.   FEBS Journal

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

(2013) Xiaoming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of NVP-TNKS656: The Use of Structure–Efficiency Relationships To Generate a Highly Potent, Selective, and Orally Active Tankyrase Inhibitor

(2013) Michael D. Shultz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

The Nedd4-like ubiquitin E3 ligases target angiomotin/p130 to ubiquitin-dependent degradation

(2012) Chenji Wang et al.   BIOCHEMICAL JOURNAL

Tankyrase and the Canonical Wnt Pathway Protect Lung Cancer Cells from EGFR Inhibition

(2012) Matias Casás-Selves et al.   CANCER RESEARCH

Tankyrase-targeted therapeutics: expanding opportunities in the PARP family

(2012) Jenna L. Riffell et al.   NATURE REVIEWS DRUG DISCOVERY

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment

(2012) S. Morrone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration of intercellular signaling through the Hippo pathway

(2012) Kenneth D. Irvine   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Taxol Resistance in Breast Cancer Cells Is Mediated by the Hippo Pathway Component TAZ and Its Downstream Transcriptional Targets Cyr61 and CTGF

(2011) D. Lai et al.   CANCER RESEARCH

Loss of Tankyrase-Mediated Destruction of 3BP2 Is the Underlying Pathogenic Mechanism of Cherubism

(2011) Noam Levaot et al.   CELL

Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease

(2011) Sebastian Guettler et al.   CELL

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

(2011) B. Zhao et al.   GENES & DEVELOPMENT

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

(2011) Murugan Paramasivam et al.   MOLECULAR BIOLOGY OF THE CELL

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

(2011) Yue Zhang et al.   NATURE CELL BIOLOGY

The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals

(2010) Nailing Zhang et al.   DEVELOPMENTAL CELL

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

Angiomotin-like Proteins Associate with and Negatively Regulate YAP1

(2010) Wenqi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

(2009) Shih-Min A. Huang et al.   NATURE

Synergistic drug combinations tend to improve therapeutically relevant selectivity

(2009) Joseph Lehár et al.   NATURE BIOTECHNOLOGY

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Tankyrase function at telomeres, spindle poles, and beyond

(2007) Susan J. Hsiao et al.   BIOCHIMIE