The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor

Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia

(2016) Z. Tan et al.   BIOCHEMICAL JOURNAL

CaMKII and Heart Failure Promote a Pathological Ryanodine Receptor Conformation that Reduces Calmodulin Binding and Enhances SR Ca2+ Leak

(2016) Hitoshi Uchinoumi et al.   BIOPHYSICAL JOURNAL

Spectrum and Prevalence ofCALM1-,CALM2-, andCALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE

(2016) Nicole J. Boczek et al.   Circulation-Cardiovascular Genetics

Spectrum and Prevalence ofCALM1-,CALM2-, andCALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome–Associated Calmodulin Missense Variant, E141GCLINICAL PERSPECTIVE

(2016) Nicole J. Boczek et al.   Circulation-Cardiovascular Genetics

Calmodulin 2 Mutation N98S Is Associated with Unexplained Cardiac Arrest in Infants Due to Low Clinical Penetrance Electrical Disorders

(2016) Juan Jiménez-Jáimez et al.   PLoS One

Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease

(2015) Vyronia Vassilakopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

(2015) Mads T. Søndergaard et al.   FEBS Journal

Arrhythmogenic Calmodulin Mutations Affect the Activation and Termination of Cardiac Ryanodine Receptor-mediated Ca2+Release

(2015) Mads T. Søndergaard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity

(2015) Tetsuro Oda et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ryanodine Receptors: Allosteric Ion Channel Giants

(2015) Filip Van Petegem   JOURNAL OF MOLECULAR BIOLOGY

Lobe-Specific Calmodulin Binding to Different Ryanodine Receptor Isoforms

(2014) Kelvin Lau et al.   BIOCHEMISTRY

Genetic and Clinical Advances in Congenital Long QT Syndrome

(2014) Yuka Mizusawa et al.   CIRCULATION JOURNAL

Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants

(2014) Hyun Seok Hwang et al.   CIRCULATION RESEARCH

Novel Calmodulin Mutations Associated With Congenital Arrhythmia Susceptibility

(2014) N. Makita et al.   Circulation-Cardiovascular Genetics

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes

(2014) Worawan B. Limpitikul et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

New antiarrhythmic targets to control intracellular calcium handling

(2014) H. E. Driessen et al.   Netherlands Heart Journal

Arrhythmogenic Calmodulin Mutations Disrupt Intracellular Cardiomyocyte Ca 2+ Regulation by Distinct Mechanisms

(2014) Guo Yin et al.   Journal of the American Heart Association

Cardiac hypertrophy associated with impaired regulation of cardiac ryanodine receptor by calmodulin and S100A1

(2013) Naohiro Yamaguchi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+release

(2013) Xixi Tian et al.   BIOCHEMICAL JOURNAL

Calmodulin Mutations Associated With Recurrent Cardiac Arrest in Infants

(2013) Lia Crotti et al.   CIRCULATION

Cardiac Myocyte Z-Line Calmodulin Is Mainly RyR2-Bound, and Reduction Is Arrhythmogenic and Occurs in Heart Failure

(2013) Yi Yang et al.   CIRCULATION RESEARCH

Calmodulin in a Heartbeat

(2013) Anders B. Sorensen et al.   FEBS Journal

Cardiac calcium signalling pathologies associated with defective calmodulin regulation of type 2 ryanodine receptor

(2013) Juan José Arnáiz-Cot et al.   JOURNAL OF PHYSIOLOGY-LONDON

A Mutation in CALM1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence

(2013) Roos F. Marsman et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Dynamic switching of calmodulin interactions underlies Ca2+ regulation of CaV1.3 channels

(2013) Manu Ben Johny et al.   Nature Communications

Mutations in Calmodulin Cause Ventricular Tachycardia and Sudden Cardiac Death

(2012) Mette Nyegaard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Inherited calcium channelopathies in the pathophysiology of arrhythmias

(2012) Luigi Venetucci et al.   Nature Reviews Cardiology

Structural Basis for Calmodulin as a Dynamic Calcium Sensor

(2012) Miao Zhang et al.   STRUCTURE

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

(2011) Qiang Zhou et al.   NATURE MEDICINE

Calcium Signaling in Cardiac Myocytes

(2011) C. J. Fearnley et al.   Cold Spring Harbor Perspectives in Biology

Site-specific modification of calmodulin Ca2+affinity tunes the skeletal muscle ryanodine receptor activation profile

(2010) Jie Jiang et al.   BIOCHEMICAL JOURNAL

Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca2+ release in heart failure

(2010) Makoto Ono et al.   CARDIOVASCULAR RESEARCH

Ryanodine Receptor Luminal Ca2+ Regulation: Swapping Calsequestrin and Channel Isoforms

(2009) Jia Qin et al.   BIOPHYSICAL JOURNAL

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL