Article
Multidisciplinary Sciences
Wenpeng Song, Yiming Yuan, Xiaohui Tan, Yangyang Gu, Jianyu Zeng, Weidong Song, Zhongcheng Xin, Dong Fang, Ruili Guan
Summary: This study investigated the effect and mechanism of Icariside II on the rapid phosphorylation of eNOS. The results demonstrated that Icariside II can promote cell proliferation and nitric oxide release, and regulate the phosphorylation of eNOS through multiple signaling pathways.
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tatsiana Suvorava, Sara Metry, Stephanie Pick, Georg Kojda
Summary: Vascular tone regulation by nitric oxide is a crucial physiological function, with endothelial dysfunction potentially being an underlying cause of hypertension. Increasing eNOS activity reduces blood pressure, while decreasing activity has the opposite effect. These findings have important implications for pre-hypertensive treatment.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Biochemistry & Molecular Biology
Xiao-xue Liang, Rui-yu Wang, Yong-zheng Guo, Zhe Cheng, Ding-yi Lv, Ming-hao Luo, An He, Su-xin Luo, Yong Xia
Summary: This study indicates that phosphorylation of Akt at Thr308, rather than at Ser473, plays a more significant role in regulating p-eNOS Ser1177 levels under physiological conditions.
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biochemistry & Molecular Biology
Shinya Yokomizo, Malte Roessing, Atsuyo Morita, Timo Kopp, Emiyu Ogawa, Wataru Katagiri, Susanne Feil, Paul L. Huang, Dmitriy N. Atochin, Satoshi Kashiwagi
Summary: This study provides evidence that NIR-II laser enhances bioavailable NO in endothelial cells, suggesting its potential use in restoring endothelial NO and treating or preventing cardiovascular diseases.
Article
Pharmacology & Pharmacy
Soshi Narasaki, Soma Noguchi, Tomoaki Urabe, Kana Harada, Izumi Hide, Shigeru Tanaka, Yuhki Yanase, Taketoshi Kajimoto, Kazue Uchida, Yasuo M. Tsutsumi, Norio Sakai
Summary: The aim of this study was to identify the PKC domains involved in propofol-induced PKC translocation. The results showed that the C1 and C2 domains of PKCα and the C1B domain of PKC8 are involved in propofol-induced PKC translocation. In addition, the C1 domain inhibitor calphostin C inhibited propofol-induced PKC8 translocation and phosphorylation of endothelial nitric oxide synthase.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiao Zhang, Bing Tian, Qin Deng, Jian Cao, Xionghui Ding, Qingshuang Liu, Yunfei Zhang, Cuilian Ye, Chun Deng, Lin Qiu, Chunbao Guo
Summary: The current study suggests that NR treatment improves the survival of experimental NEC mice through modulation of SIRT1-associated eNOS acetylation/deacetylation, which is implicated in endothelial dysfunction.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Hyun-Jin Kim, Sung Il Bae, Ji-Yoon Kim, Kyeong-Eon Park, Yeran Hwang, Ju-Tae Sohn
Summary: This study found that lipid emulsion enhanced the vasoconstriction induced by dexmedetomidine by inhibiting nitric oxide synthesis, potentially through reducing dexmedetomidine concentration. Dexmedetomidine-induced nitric oxide synthesis may be caused by Src kinase-induced caveolin-1 phosphorylation leading to increased eNOS (Ser1177) phosphorylation and decreased eNOS (Thr495) phosphorylation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Giulia Querio, Susanna Antoniotti, Federica Geddo, Renzo Levi, Maria Pia Gallo
Summary: TMAO may be involved in impairing the endothelial-dependent vasodilatory mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Joseph Festa, Mariasole Da Boit, Aamir Hussain, Harprit Singh
Summary: Cardiovascular disease is the leading cause of global death, with endothelial dysfunction being a predictor for most CVD. Polyphenols from sources like wine and grape extracts can help prevent endothelial dysfunction, while anthocyanin flavonoids found in berries also improve vascular function.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chih-Hsien Wu, Yi-Lin Chiu, Chung-Yueh Hsieh, Guo-Shiang Tsung, Lian-Shan Wu, Cheng-Chung Cheng, Tsung-Neng Tsai
Summary: Cilostazol exerts antithrombotic and vasculoprotective effects in endothelial cells by activating KLF2 and SIRT1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Anees Ahmed Syed, Mohammed Shafiq, Mohammad Irshad Reza, Pragya Bharati, Athar Husain, Pragati Singh, Kashif Hanif, Jiaur R. Gayen
Summary: The chronic treatment of Cissus quadrangularis extract improved endothelium-dependent relaxation in spontaneously hypertensive rats by activating eNOS and inhibiting ROS production and inflammation, leading to antihypertensive effects.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Hematology
Ashif Iqubal, Mansoor Ali Syed, Mohammad Mahfuzul Haque, Abul Kalam Najmi, Javed Ali, Syed Ehtaishamul Haque
EXPERIMENTAL HEMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Joseph J. Porter, Hyo Sang Jang, Mohammad Mahfuzul Haque, Dennis J. Stuehr, Ryan A. Mehl
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Victor Garcia, Eon Joo Park, Mauro Siragusa, Florian Frohlich, Mohammad Mahfuzul Haque, Jonathan V. Pascale, Katherine R. Heberlein, Brant E. Isakson, Dennis J. Stuehr, William C. Sessa
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Ashif Iqubal, Mansoor Ali Syed, Javed Ali, Abul Kalam Najmi, Mohammad Mahfuzul Haque, Syed Ehtaishamul Haque
Article
Biochemistry & Molecular Biology
Kulwant S. Aulak, Jarrod W. Barnes, Liping Tian, Noel E. Mellor, Mohammad M. Haque, Belinda Willard, Ling Li, Suzy C. Comhair, Dennis J. Stuehr, Raed A. Dweik
Article
Biochemistry & Molecular Biology
Aanchal Rathi, Dhiraj Kumar, Gulam Mustafa Hasan, Mohammad Mahfuzul Haque, Md Imtaiyaz Hassan
Summary: This review article focuses on the physiological significance of PIM kinases in disease progression and therapeutic targeting, as well as predicting functional partners of PIM kinases and mapping their interaction network in cellular physiology of different cancers. The study also provides insight into the mechanism of inhibition and implication of designed inhibitors towards therapeutic management of prostate, breast and other cancers.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Biophysics
Yufan He, Mohammad Mahfuzul Haque, Dennis J. Stuehr, H. Peter Lu
Summary: By utilizing single-molecule fluorescence resonance energy transfer spectroscopy and a new imaging approach, researchers investigated the conformational states and fluctuation dynamics of nitric oxide synthase enzymes, discovering a new conformational state induced by calmodulin binding. These findings provide valuable insights into the mechanism of NOS electron transfer.
BIOPHYSICAL JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Mohamed Shiffa, M. Aslam, M. H. Kazmi, Syed Mansoor Ali, Nazeem Fahamiya, Mohammad Mahfuzul Haque
Summary: This study aims to establish physicochemical and phytochemical quality standards for a novel herbal formulation. The results showed specific values for extractive values, ash, pH, and the presence of various plant metabolites and active ingredients.
INTERNATIONAL JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Zainab Mirza, Mohammad Mahfuzul Haque, Meetu Gupta
Summary: Arsenic is a global carcinogenic contaminant that limits the development and yield of crop plants. It is closely associated with rice and accumulates in grains, posing a health risk to humans. WRKY transcription factors show promise in addressing arsenic-related issues in rice, but further research is needed.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Chemistry, Physical
Daraksha Yameen, Seerat Siraj, Zahoor Ahmad Parray, Mohammad Masood, Asimul Islam, Mohammad Mahfuzul Haque
Summary: In this study, the effect of crowding on the conformation of cytochrome c was investigated using synthetic crowders. The results showed that the presence of glucose led to the formation of a molten globule, while the presence of dextran 70 resulted in a pre-molten globule state. These findings suggest that crowders can protect proteins under harsh conditions and have important biological implications.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biochemistry & Molecular Biology
Sobia Khan, Seerat Siraj, Mohammad Shahid, Mohammad Mahfuzul Haque, Asimul Islam
Summary: The proper functioning of proteins relies on their proper folding mechanism to achieve their three-dimensional conformation. Failure to do so can lead to the formation of abnormal structures and various diseases, including neurodegenerative diseases and cancers. Hydration of proteins is essential and can be achieved by the presence of osmolytes, which maintain osmotic balance within the cell and prevent cellular damage. Osmolytes interact with proteins through non-covalent forces and their effectiveness can be determined using the m value. Therefore, osmolytes have potential therapeutic applications in drug development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Seerat Siraj, Daraksha Yameen, Anas Shamsi, Faizya Khan, Asimul Islam, Mohammad Mahfuzul Haque
Summary: Protein aggregation is a major side reaction that may occur during protein folding and can interfere with protein function. Fluorescence spectroscopy is used to monitor protein aggregation in vitro using extrinsic fluorescent dyes. This study investigated the interaction between these dyes and macromolecular crowding agents, providing evidence of their binding.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Rashid Waseem, Daraksha Yameen, Tanzeel Khan, Ayesha Anwer, Syed Naqui Kazim, Mohammad Mahfuzul Haque, Md. Imtaiyaz Hassan, Asimul Islam
Summary: Over the past 20 years, the problem of protein misfolding and aggregation has become a highly competitive and challenging research topic, as it is directly or indirectly associated with a wide range of human pathologies. Irisin, an exercise-induced myokine, plays an important role in various physiological processes. This study provides the first report on the thermal aggregation profile of irisin and investigates the effect of trehalose on its aggregation using spectroscopic and microscopic techniques. The results suggest that trehalose can prevent irisin aggregation in a dose-dependent manner and may have potential therapeutic applications for aggregation-related disorders.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biotechnology & Applied Microbiology
Prithvi Singh, Aanchal Rathi, Rashmi Minocha, Anuradha Sinha, Mohammad Mahfuzul Haque, Md Imtaiyaz Hassan, Ravins Dohare
Summary: Breast cancer, the second-most common type of cancer and leading cause of cancer-related deaths worldwide, exhibits marked person-to-person variability in susceptibility, phenotypic expression, and prognosis. In this study, we identified PI15 and KRT5 as prognostic hub genes and potential biomarkers in breast cancer, highlighting the need for personalized medicine.
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Mohammad Hague, Fengyang Lei, Xiaofang Xiong, Jugal Kishore Das, Xingcong Ren, Deyu Fang, Shahram Salek-Ardakani, Jin-Ming Yang, Jianxun Song