The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression

Ixazomib: First Global Approval

(2016) Matt Shirley   DRUGS

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

(2016) Y. Shi et al.   SCIENCE

Gates, Channels, and Switches: Elements of the Proteasome Machine

(2016) Daniel Finley et al.   TRENDS IN BIOCHEMICAL SCIENCES

Knockdown of Adhesion-Regulating Molecule 1 Inhibits Proliferation in HL60 Cells

(2015) Xiaohui Zheng et al.   ACTA HAEMATOLOGICA

A Reversible and Highly Selective Inhibitor of the Proteasomal Ubiquitin Receptor Rpn13 Is Toxic to Multiple Myeloma Cells

(2015) Darci J. Trader et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural Plasticity Allows UCH37 to Be Primed by RPN13 or Locked Down by INO80G

(2015) Xiang Chen et al.   MOLECULAR CELL

Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G

(2015) Danny D. Sahtoe et al.   MOLECULAR CELL

Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase

(2015) Ryan T. VanderLinden et al.   MOLECULAR CELL

Sequence composition of disordered regions fine-tunes protein half-life

(2015) Susan Fishbain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells

(2015) Xiuxiu Lu et al.   PLoS One

A molecular census of 26S proteasomes in intact neurons

(2015) S. Asano et al.   SCIENCE

Sequence composition of disordered regions fine-tunes protein half-life

(2015) Susan Fishbain et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The 26S proteasome is a multifaceted target for anti-cancer therapies

(2015) Tatyana A. Grigoreva et al.   Oncotarget

ADRM1 gene amplification is a candidate driver for metastatic gastric cancers

(2014) Seok Hoon Jang et al.   CLINICAL & EXPERIMENTAL METASTASIS

Autoubiquitination of the 26S Proteasome on Rpn13 Regulates Breakdown of Ubiquitin Conjugates

(2014) H. C. Besche et al.   EMBO JOURNAL

Inherent Asymmetry in the 26S Proteasome Is Defined by the Ubiquitin Receptor RPN13

(2014) Dikla Berko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoregulation of the 26S proteasome by in situ ubiquitination

(2014) Andrew D. Jacobson et al.   MOLECULAR BIOLOGY OF THE CELL

Dss1 Is a 26S Proteasome Ubiquitin Receptor

(2014) Konstantinos Paraskevopoulos et al.   MOLECULAR CELL

SUMOylation of Psmd1 Controls Adrm1 Interaction with the Proteasome

(2014) Hyunju Ryu et al.   Cell Reports

Structural Insights into Proteasome Activation by the 19S Regulatory Particle

(2013) Aaron Ehlinger et al.   BIOCHEMISTRY

A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

(2013) Z. Tian et al.   BLOOD

A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer

(2013) Ravi K. Anchoori et al.   CANCER CELL

Molecular Profiling of Human Mammary Gland Links Breast Cancer Risk to a p27+ Cell Population with Progenitor Characteristics

(2013) Sibgat Choudhury et al.   Cell Stem Cell

Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer

(2013) Marlena Fejzo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

CRISPR interference (CRISPRi) for sequence-specific control of gene expression

(2013) Matthew H Larson et al.   Nature Protocols

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Cell cycle regulation by the intrinsically disordered proteins p21 and p27

(2012) Mi-Kyung Yoon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

(2012) Alexei F. Kisselev et al.   CHEMISTRY & BIOLOGY

Expression and Clinical Significance of UCH37 in Human Esophageal Squamous Cell Carcinoma

(2012) Yanjie Chen et al.   DIGESTIVE DISEASES AND SCIENCES

Ubiquitin and its binding domains

(2012) Leah Randles   Frontiers in Bioscience-Landmark

Rpn1 and Rpn2 Coordinate Ubiquitin Processing Factors at Proteasome

(2012) Rina Rosenzweig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete subunit architecture of the proteasome regulatory particle

(2012) Gabriel C. Lander et al.   NATURE

Localization of the proteasomal ubiquitin receptors Rpn10 and Rpn13 by electron cryomicroscopy

(2012) E. Sakata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Proteasome Inhibitors to Overcome Bortezomib Resistance

(2011) Amy M. Ruschak et al.   JNCI-Journal of the National Cancer Institute

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Inhibition of proteasome deubiquitinating activity as a new cancer therapy

(2011) Pádraig D'Arcy et al.   NATURE MEDICINE

Ubiquitylation and proteasomal degradation of the p21Cip1, p27Kip1and p57Kip2CDK inhibitors

(2010) Zhimin Lu et al.   CELL CYCLE

Emerging roles of deubiquitinases in cancer-associated pathways

(2010) Joseph J. Sacco et al.   IUBMB LIFE

Structure of Proteasome Ubiquitin Receptor hRpn13 and Its Activation by the Scaffolding Protein hRpn2

(2010) Xiang Chen et al.   MOLECULAR CELL

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

Together, Rpn10 and Dsk2 Can Serve as a Polyubiquitin Chain-Length Sensor

(2009) Daoning Zhang et al.   MOLECULAR CELL

Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13

(2009) Naixia Zhang et al.   MOLECULAR CELL

Targeting Proteins for Destruction by the Ubiquitin System: Implications for Human Pathobiology

(2008) Alan L. Schwartz et al.   Annual Review of Pharmacology and Toxicology

Distinct Modes of Regulation of the Uch37 Deubiquitinating Enzyme in the Proteasome and in the Ino80 Chromatin-Remodeling Complex

(2008) Tingting Yao et al.   MOLECULAR CELL

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

(2008) Patrick Schreiner et al.   NATURE

Proteasome subunit Rpn13 is a novel ubiquitin receptor

(2008) Koraljka Husnjak et al.   NATURE