Article
Oncology
Kara A. Michels, Ashley M. Geczik, Doug C. Bauer, Louise A. Brinton, Diana S. M. Buist, Jane A. Cauley, Cher M. Dallal, Roni T. Falk, Trisha F. Hue, James V. Lacey, Andrea Z. LaCroix, Jeffrey A. Tice, Xia Xu, Britton Trabert
Summary: The study found that progestogens are generally not associated with colorectal cancer risk in postmenopausal women. These findings are consistent with prior research on circulating endogenous sex hormones, suggesting that sex hormones may not be major drivers of colorectal carcinogenesis in postmenopausal women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Biochemistry & Molecular Biology
Swati Sucharita Mohanty, Prafulla Kumar Mohanty
Summary: Breast cancer is the second most prevalent cancer globally, with a significant relationship between obesity and increased risk of developing the disease. Premature menopause and premenopausal obesity decrease the risk, while postmenopausal obesity amplifies it due to adipose tissue being a major reservoir for estrogen biosynthesis. High estrogen levels in overweight postmenopausal women are seen as a major factor in breast cancer development.
Article
Oncology
Chuner Jiang, Peng Wu, Xiangming He, Jianfen Ni, Xiaowen Ding, Xiaohong Xu, Fangzheng Wang, Dehong Zou
Summary: This study investigated the relationship between serum reproductive hormone concentrations and patient characteristics and hormone receptor status among postmenopausal Chinese women with breast cancer. The results showed that decreased serum LH and FSH levels were associated with increased ER and PR expressions and decreased HER2 expression in postmenopausal patients with breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Orthopedics
Zhongxin Zhu, Jin Zhao, Yanfei Fang, Rongwei Hua
Summary: The study found a positive association between serum E2 level and lumbar BMD, with an inverted U-shaped relationship identified with a inflection point at E2 level of 70 pg/mL. There was no significant association between SHBG level and lumbar BMD, but a U-shaped relationship was observed with a inflection point at SHBG level of 65 nmol/L.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Endocrinology & Metabolism
Victoria Persky, Chibuzor Abasilim, Konstantina Tsintsifas, Tessa Day, Robert M. Sargis, Martha L. Daviglus, Jianwen Cai, Sally Freels, Terry Unterman, Noel Chavez, Robert Kaplan, Carmen R. Isasi, Amber Pirzada, Michelle L. Meyer, Gregory A. Talavera, Bharat Thyagarajan, Brandilyn A. Peters, Jessica M. Madrigal, Arielle Grieco, Mary E. Turyk
Summary: This study examined the associations between endogenous sex hormones and diabetes progression. It found an inverse association between testosterone levels in men and conversion from prediabetes to diabetes, and an inverse association between SHBG levels in women and various glycemic measures as well as prediabetes to diabetes conversion.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Antonella Grasso, Antonio Di Zazzo, Giuseppe Giannaccare, Jaemyoung Sung, Takenori Inomata, Kendrick Co Shih, Alessandra Micera, Daniele Gaudenzi, Sara Spelta, Maria Angela Romeo, Paolo Orsaria, Marco Coassin, Vittorio Altomare
Summary: Sex hormones, especially androgens and estrogens, play significant roles in the pathogenesis of dry eye syndrome. Systemic hormonal replacement treatments may have contradictory effects on ocular surface homeostasis, making it crucial to assess patients with hormonal imbalances such as breast cancer for dry eye disease.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Yuqing Wang, Ruxianguli Aimuzi, Min Nian, Yu Zhang, Kai Luo, Jun Zhang
Summary: The study revealed positive associations between certain PFAS and androgen levels in postmenopausal women, particularly in overweight/obese individuals. Further research is needed to explore the potential mechanisms underlying this association and its implications for cardiometabolic diseases.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Janghee Lee, Hakyoung Kim, Soong June Bae, Jung Hwan Ji, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn, Joon Jeong, Sae Byul Lee, Sung Gwe Ahn
Summary: This study found that BMI may affect the 21-gene recurrence score in patients with ER-positive, ERBB2-negative breast cancer, suggesting that weight control becomes more important in the prevention and treatment of breast cancer.
Article
Oncology
Rhonda S. Arthur, Andrew J. Dannenberg, Thomas E. Rohan
Summary: The study indicates that postmenopausal breast cancer risk among normal weight women is associated with higher levels of CRP and testosterone, and lower levels of SHBG. These associations persist even after adjustments for BMI, fat mass index, or waist circumference.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Endocrinology & Metabolism
Anela Blazevic, Anand M. Iyer, Marie-Louise F. Van Velthuysen, Johannes Hofland, Lindsey Oudijk, Wouter W. de Herder, Leo J. Hofland, Richard A. Feelders
Summary: Small-intestinal neuroendocrine tumors (SI-NETs) have a higher prevalence and worse prognosis in male patients. This study found that mesenteric metastasis and fibrosis were more common in men than women. The risk of mesenteric metastasis in women increased around menopause. The expression of estrogen receptor alpha and androgen receptor was observed in primary tumors and mesenteric metastases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Immunology
Victoria Peer, Khitam Muhsen, Moshe Betser, Manfred S. Green
Summary: Pregnant women have lower immune response to pertussis vaccination compared to non-pregnant women, possibly due to higher levels of hormones during pregnancy. Sex hormones during pregnancy, such as progesterone and estrogen, are negatively associated with anti-pertussis toxin antibody levels.
Review
Immunology
Suriya Rehman, Vijaya Ravinayagam, Insha Nahvi, Hanan Aldossary, Maha Al-Shammari, Mai Saad Al Amiri, Uday Kishore, Ebtesam A. A. Al-Suhaimi
Summary: This study discusses the significant impact of gender on morbidity and mortality of COVID-19, with factors such as innate immune response, estrogen, and microbiota potentially contributing to gender differences. It also highlights certain factors that give women greater resistance to SARS-CoV-2 infection and disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Matteo Lambertini, Claudia Massarotti, Julie Havas, Barbara Pistilli, Anne-Laure Martin, Alexandra Jacquet, Charles Coutant, Florence Coussy, Asma Dhaini Merimeche, Florence Lerebours, Christine Rousset-Jablonski, Christelle Jouannaud, Olivier Rigal, Marion Fournier, Patrick Soulie, Maria Alice Franzoi, Lucia Del Mastro, Ann H. Partridge, Fabrice Andre, Ines Vaz-Luis, Antonio Di Meglio
Summary: As life expectancy increases for cancer patients, survivorship has become a crucial aspect of breast cancer care. Adequate contraceptive counseling is important for premenopausal breast cancer patients who do not wish to become pregnant. This study examined contraceptive use and methods in early breast cancer patients and identified factors associated with contraceptive use over time. The findings highlight the importance of raising awareness and providing targeted contraceptive counseling for premenopausal women with early breast cancer.
Article
Gastroenterology & Hepatology
Monika A. Sarkar, Ayako Suzuki, Manal F. Abdelmalek, Katherine P. Yates, Laura A. Wilson, Nathan M. Bass, Ryan Gill, Marcelle Cedars, Norah Terrault
Summary: In young women with NAFLD, higher testosterone levels are associated with increased disease severity, particularly in the youngest age group. Elevated testosterone levels may pose a greater risk for NASH and NASH fibrosis, as well as abdominal adiposity.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Hannah Oh, Nazmus Saquib, Heather M. Ochs-Balcom, Ruth M. Pfeiffer, Phyllis A. Richey, Aladdin H. Shadyab, Robert A. Wild, Lisa Underland, Garnet L. Anderson, Xia Xu, Britton Trabert
Summary: This study found that prolonged sitting and physical inactivity are associated with higher estrogen-to-androgen ratios in postmenopausal women, but not with androgen metabolites. This contributes to our understanding of the link between physical activity, sitting, and cancer risk in this population.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Oncology
Hamed Samavat, Allison M. Dostal, Renwei Wang, Sarah Bedell, Tim H. Emory, Giske Ursin, Carolyn J. Torkelson, Myron D. Gross, Chap T. Le, Mimi C. Yu, Chung S. Yang, Douglas Yee, Anna H. Wu, Jian-Min Yuan, Mindy S. Kurzer
CANCER CAUSES & CONTROL
(2015)
Article
Nutrition & Dietetics
Allison M. Dostal, Hamed Samavat, Luis Espejo, Andrea Y. Arikawa, Nicole R. Stendell-Hollis, Mindy S. Kurzer
JOURNAL OF NUTRITION
(2016)
Article
Nutrition & Dietetics
Hamed Samavat, April R. Newman, Renwei Wang, Jian-Min Yuan, Anna H. Wu, Mindy S. Kurzer
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Nutrition & Dietetics
Andrea Y. Arikawa, Hamed Samavat, Myron Gross, Mindy S. Kurzer
JOURNAL OF NUTRITION
(2017)
Article
Nutrition & Dietetics
Hamed Samavat, Anna H. Wu, Giske Ursin, Carolyn J. Torkelson, Renwei Wang, Mimi C. Yu, Douglas Yee, Mindy S. Kurzer, Jian-Min Yuan
JOURNAL OF NUTRITION
(2019)
Article
Oncology
Hamed Samavat, Hung N. Luu, Kenneth B. Beckman, Aizhen Jin, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan
Summary: The study revealed that longer telomeres are associated with an increased risk of cancer development, especially for common cancer types like breast, rectal, prostate, pancreatic cancer, and lung adenocarcinoma. Conversely, longer telomeres are linked to a decreased risk of noncancer related death.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Erin Kenny, Hamed Samavat, Riva Touger-Decker, J. Scott Parrott, Laura Byham-Gray, David Allen August
Summary: A study revealed a significant association between more than a 10% weight loss prior to gastrointestinal cancer surgery and adverse perioperative outcomes. The contribution of nutrition status markers to surgical outcomes was found to be small, which is a novel finding.
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Amanda Groesbeck, Rena Zelig, Hamed Samavat, Rebecca Brody
Summary: This study evaluated the perceived value of the board-certified specialist in renal nutrition credential and found that those who received reimbursement for their credential examination had higher perceived extrinsic value. The results of this research are of great significance for understanding the perspectives and recognition of healthcare professionals towards specialist certification.
JOURNAL OF RENAL NUTRITION
(2022)
Review
Nutrition & Dietetics
Donna Gallagher, Anna Parker, Hamed Samavat, Rena Zelig
Summary: Prophylactic supplementation of phosphate, magnesium, and potassium has been found to be effective in preventing refeeding syndrome in patients with anorexia nervosa, but further randomized controlled trials are needed to evaluate its safety and effectiveness, as feeding approaches and study populations vary widely.
NUTRITION IN CLINICAL PRACTICE
(2022)
Review
Nutrition & Dietetics
Michaelann Hahn, Hamed Samavat, Anna Parker, Rena Zelig
Summary: Patients with traumatic brain injury in the outpatient or rehabilitation setting commonly have vitamin D deficiency, and may benefit from monitoring of laboratory assays and supplementation as needed.
TOPICS IN CLINICAL NUTRITION
(2021)
Article
Dentistry, Oral Surgery & Medicine
S. Honeywell, H. Samavat, R. Touger-Decker, J. S. Parrott, E. Hoskin, R. Zelig
Summary: This study investigated the association between nutritional status and dentition status among older adults. The results suggest that older adults with more teeth, better occlusion, and functional dentition are more likely to have normal nutritional status.
JDR CLINICAL & TRANSLATIONAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Laura Acosta, Laura Byham-Gray, Mindy Kurzer, Hamed Samavat
Summary: The study investigated the influence of COMT and UGT1A4 genotypes on changes in liver injury biomarkers in response to long-term, high-dose green tea extract supplementation among postmenopausal women. The results suggest that the UGT1A4 genotype may be an important risk factor for clinically-relevant liver damage in postmenopausal women after high-dose green tea extract supplementation.
JOURNAL OF DIETARY SUPPLEMENTS
(2023)
Article
Oncology
Hamed Samavat, Xiaoshuang Xun, Aizhen Jin, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan
BREAST CANCER RESEARCH
(2019)
Article
Oncology
Zheming Yu, Hamed Samavat, Allison M. Dostal, Renwei Wang, Carolyn J. Torkelson, Chung S. Yang, Lesley M. Butler, Thomas W. Kensler, Anna H. Wu, Mindy S. Kurzer, Jian-Min Yuan
CANCER PREVENTION RESEARCH
(2017)
Article
Oncology
Hamed Samavat, Giske Ursin, Tim H. Emory, Eunjung Lee, Renwei Wang, Carolyn J. Torkelson, Allison M. Dostal, Karen Swenson, Chap T. Le, Chung S. Yang, Mimi C. Yu, Douglas Yee, Anna H. Wu, Jian-Min Yuan, Mindy S. Kurzer
CANCER PREVENTION RESEARCH
(2017)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
