Article
Pharmacology & Pharmacy
Bharat Pateliya, Vinod Burade, Sunita Goswami
Summary: The concomitant use of naringenin and metformin with doxorubicin chemotherapy showed increased cytotoxicity in TNBC cells in vitro and reduced tumor volume and weight in vivo, enhancing antitumor activity. Biopsies demonstrated increased necrosis and inhibited cell proliferation. No adverse effects were observed in organs, blood glucose, cardiac histology, or Troponin I levels. Additionally, the combination led to reduced dose-related body weight loss and increased cytokines compared to a high dose of doxorubicin alone, indicating its potential as an adjunct therapy for improved effectiveness against breast carcinoma.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Linlin Lu, Zihe Niu, Zhujun Chao, Cuiping Fu, Kai Chen, Yaqin Shi
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, and standard treatment options are limited. Antibody-drug conjugates (ADCs) have shown promise in clinical studies, but resistance is a challenge. Combining ADCs with other treatment strategies may provide a more effective approach.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Xupeng Bai, Jie Ni, Julia Beretov, Shanping Wang, Xingli Dong, Peter Graham, Yong Li
Summary: The study shows that THOC2 and THOC5 are upregulated in radioresistant TNBC cells, promoting stem-like properties and radioresistance. Silencing THOC2 or THOC5 expression decreases protein expression of SOX2 and NANOG, depletes stem-like properties, and causes radiosensitization in TNBC cells. Depletion of THOC2 or THOC5 blocks xenograft tumorigenesis and growth of radioresistant TNBC in vivo, suggesting potential therapeutic strategies against relapsed TNBC.
Article
Pharmacology & Pharmacy
Alejandra Estepa-Fernandez, Alba Garcia-Fernandez, Araceli Lerida-Viso, Juan F. Blandez, Irene Galiana, Felix Sancenon-Galarza, Mar Orzaez, Ramon Martinez-Manez
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options. Inducing senescence and removing senescent cells (senolysis) has been explored as a method to limit tumor progression. In this study, a combination treatment using palbociclib and navitoclax was found to delay tumor growth and reduce metastasis in a mouse model of aggressive TNBC.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xiaoyan Jiang, Xu Zhi, Peixia Zhang, Zhongmei Zhou, Jinxiang Ye, Yu Gao, Xinye Wang, Chuanyu Yang, Haijun Chen, Rong Liu, Ceshi Chen
Summary: The study identified that the isochromanoindolenine derivative FZU-0025-065 inhibits TNBC by suppressing the AKT signaling pathway, showing potential for TNBC treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Lixia Cao, Shaorong Zhao, Qianxi Yang, Zhendong Shi, Jingjing Liu, Teng Pan, Dongdong Zhou, Jin Zhang
Summary: This study aimed to demonstrate the potential of chidamide (CHI) combined with the chemotherapy drug doxorubicin (DOX) to overcome chemotherapeutic resistance of MDR breast cancer. The results showed that CHI combined with DOX exhibited significant cytotoxicity to MDR breast cancer cells and induced cell apoptosis by activating the p53 pathway.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yihang Gong, Wenjie Chen, Xiuxing Chen, Yizhan He, Hua Jiang, Xijian Zhang, Lijie Pan, Beibei Ni, Fan Yang, Yan Xu, Qi Zhang, Lei Zhou, Yusheng Cheng
Summary: The study demonstrates that suberoylanilide hydroxamic acid (SAHA) and 3-methyl adenine (3MA) can be used to enhance umbilical cord blood-based natural killer (UCB-NK) cell therapy for triple-negative breast cancer (TNBC). An injectable hydrogel is designed to codeliver SAHA and 3MA and exhibits excellent anti-relapse efficacy and hemostasis and wound-healing functions.
Article
Oncology
Roberto Ruiu, Giuseppina Barutello, Maddalena Arigoni, Federica Riccardo, Laura Conti, Giulia Peppino, Laura Annaratone, Caterina Marchio, Giulio Mengozzi, Raffaele Adolfo Calogero, Federica Cavallo, Elena Quaglino
Summary: TNBC patients have poor overall survival due to high recurrence rates, with aggressive cancer stem cells (CSC) playing a key role. TENM4 shows potential as a biomarker and therapeutic target for TNBC treatment.
Article
Oncology
Jessica L. S. Zylla, Mariah M. Hoffman, Simona Plesselova, Somshuvra Bhattacharya, Kristin Calar, Yohannes Afeworki, Pilar de la Puente, Etienne Z. Gnimpieba, W. Keith Miskimins, Shanta M. Messerli
Summary: We investigated the potential use of the small molecule epigenetic modulator 4SC-202 as a therapeutic or adjuvant for Triple Negative Breast Cancer (TNBC). The study showed that 4SC-202 effectively killed tumor cells, reduced their ability to migrate, and decreased metastasis and tumor burden in a murine model of TNBC. This preclinical study provides critical information on the potential efficacy of 4SC-202 for TNBC.
Article
Pharmacology & Pharmacy
Md Abdus Subhan, Vladimir P. Torchilin
Summary: Antibody-drug conjugate-based therapy combines the high specificity of antibodies with the strong potency of payloads, showing potential efficacy in breast cancer treatment. Despite the challenge of ADC resistance, several ADC therapies have shown progress in cancer treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Xiang-jin Zheng, Wan Li, Jie Yi, Jin-yi Liu, Li-wen Ren, Xiao-ming Zhu, Shi-wei Liu, Jin-hua Wang, Guan-hua Du
Summary: This study identified high expression of FOXC1 in TNBC, which was associated with overall survival (OS) of patients and inversely correlated with H3K27me3 levels. Inhibition of EZH2 increased FOXC1 expression, which was also linked to doxorubicin resistance in breast cancer cells. This suggests that FOXC1 may serve as a potential biomarker or drug target for TNBCs, and downregulation of FOXC1 could be therapeutically valuable in TNBC treatment.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Oncology
Priyanka Shailendra Rana, Wei Wang, Akram Alkrekshi, Vesna Markovic, Amer Khiyami, Ricky Chan, Adam Perzynski, Natalie Joseph, Khalid Sossey-Alaoui
Summary: This study highlights the significant role of the YB1 gene in the disparities of TNBC between African American and Caucasian American women. YB1 is highly expressed in TNBC tumors of African American origin, correlating with poor disease outcomes and resistance to chemotherapy. Targeted inhibition of YB1 expression and activity could potentially reduce these health disparities in TNBC.
Review
Chemistry, Multidisciplinary
Saikat Ghosh, Ankit Javia, Saritha Shetty, Denish Bardoliwala, Kuntal Maiti, Shubhadeep Banerjee, Ajay Khopade, Ambikanandan Misra, Krutika Sawant, Subhas Bhowmick
Summary: Triple negative breast cancer (TNBC) and non-small cell lung cancer (NSCLC) are aggressive solid tumors characterized by low survival rates, high relapse incidence, tumor heterogeneity, genetic mutations, generation of cancer-stem cells, immune-resistance and chemoresistance. Emerging opportunities for effective treatment include pharmacological targets and gene-based modulation combined with nano-formulation approaches.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Wenwen Xue, Wuhao Li, Ying Yu, Bo Zhang, Yixue Wang, Lin Zhou, Zhixiu Chen, Liwei Wang, Huiming Ge, Qiang Xu, Yan Shen
Summary: This study aimed to investigate the mode of action of indolocarbazole alkaloid loonamycin A against triple-negative breast cancer. Results showed that loonamycin A exhibited stronger cytotoxicity compared to its analog rebeccamycin, inhibiting cell proliferation, migration, and reducing the expression of stemness-associated genes. Additionally, loonamycin A enhanced the antitumour effects of paclitaxel by inhibiting Notch signalling.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Sinan Cheng, Zheng Lu, Yang Feng, Xuewei Zhao, Ruixia Zhao, Zuchun Qiu, Chenshuang Jia, Lirong Chen, Yue Yuan, Xinyao Li, Qian Gao, Jie Xu, Zhan Shu, Wei Duan, Yingchun Hou, Guochao Nie, Li Xiao
Summary: Breast cancer is the most common cancer and leading cause of death in women. Current chemotherapy has low efficacy and high side effects, necessitating the development of a novel targeted drug delivery formulation. The study discovered a new drug formulation that showed satisfactory therapeutic efficacy for breast cancer, particularly for drug resistant cases.
MATERIALS TODAY ADVANCES
(2022)
Article
Cell Biology
Jiann Ruey Ong, Oluwaseun Adebayo Bamodu, Nguyen Viet Khang, Yen-Kuang Lin, Chi-Tai Yeh, Wei-Hwa Lee, Yih-Giun Cherng
Summary: The study found that SAE1 is overexpressed in HCC patients, closely associated with malignancy and prognosis, and significantly correlated with metastasis and disease progression.
Article
Neurosciences
Chen-Chih Chung, Oluwaseun Adebayo Bamodu, Chien-Tai Hong, Lung Chan, Hung-Wen Chiu
Summary: This study re-explored the predictive validity of the Stroke Prognostication using Age and National Institutes of Health Stroke Scale (SPAN) index in patients who received different treatments for acute ischemic stroke (AIS) and developed machine learning-boosted outcome prediction models. The results showed that the SPAN index is prognostically relevant in AIS patients who received different treatments, and the generated machine learning-based models exhibit good performance in predicting the functional recovery of AIS.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Oncology
Cheng-Chih Tsai, Yung-Cheng Su, Oluwaseun Adebayo Bamodu, Bo-Jung Chen, Wen-Chiuan Tsai, Wei-Hong Cheng, Chii-Hong Lee, Shu-Min Hsieh, Mei-Ling Liu, Chia-Lang Fang, Huan-Tze Lin, Chi-Long Chen, Chi-Tai Yeh, Wei-Hwa Lee, Ching-Liang Ho, Shiue-Wei Lai, Huey-En Tzeng, Yao-Yu Hsieh, Chia-Lun Chang, Yu-Mei Zheng, Hui-Wen Liu, Yun Yen, Jacqueline Whang-Peng, Tsu-Yi Chao
Summary: This study compared the epidemiological, cytogenetic, and clinical differences between patients with multiple hit diffuse large B-cell lymphoma in Taiwan and those in western countries. The majority of patients in Taiwan harbor a BCL6 rearrangement, suggesting the need for mandatory screening for BCL6 rearrangement in aggressive HGBL patients in Taiwan. Contrary to data from western countries, a significant proportion of patients in Taiwan with DH/TH-HGBL have BCL6 rearrangement.
Article
Biochemistry & Molecular Biology
Shao-Cheng Liu, Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Iat-Hang Fong, Chih-Cheng Lin, Chi-Tai Yeh, Shyi-Gen Chen
Summary: The study showed that ADSCs can promote an increase in levels of miR-29b and miR-21, leading to the activation and proliferation of dermal fibroblasts and extracellular matrix (ECM) remodeling, thereby enhancing cutaneous wound healing.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Chen-Chih Chung, Lung Chan, Jia-Hung Chen, Oluwaseun Adebayo Bamodu, Hung-Wen Chiu, Chien-Tai Hong
Summary: Plasma extracellular vesicle (EV) tau and Aβ42 are significant markers of cognitive function in Parkinson's disease (PD) patients, and can help identify cognitive dysfunction. An artificial neural network model accurately predicts cognitive function in PD patients.
Article
Cell Biology
Shiue-Wei Lai, Ming-Yao Chen, Oluwaseun Adebayo Bamodu, Ming-Shou Hsieh, Ting-Yi Huang, Chi-Tai Yeh, Wei-Hwa Lee, Yih-Giun Cherng
Summary: Exosomal PVT1 promotes colon cancer metastasis through its association with EGFR and VEGFA expression. miR-152-3p targets both PVT1 and VEGFA, and this regulatory pathway can be explored for drug development and as a prognostic biomarker.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Medicine, General & Internal
Wen-Ling Wu, Oluwaseun Adebayo Bamodu, Yuan-Hung Wang, Su-Wei Hu, Kai-Yi Tzou, Chi-Tai Yeh, Chia-Chang Wu
Summary: ESWT treatment has significant benefits for patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), effectively relieving pain, improving erectile function, and enhancing quality of life.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Jia-Hung Chen, Lung Chan, Chen-Chih Chung, Oluwaseun Adebayo Bamodu, Chien-Tai Hong
Summary: Elevated blood neurofilament light chain is being increasingly recognized as a diagnostic and outcome-predicting biomarker for neurological diseases, but its implications in Parkinson's disease remain unclear. Studies have shown conflicting data on blood NfL levels in PD cohorts, possibly due to demographic heterogeneity. By adjusting for age and gender, the comparability of NfL levels between different PD studies can be enhanced, helping to eliminate conflicting factors and enhance the understanding of this biomarker's significance.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Chia-Chang Wu, Yuan-Hung Wang, Su-Wei Hu, Wen-Ling Wu, Chi-Tai Yeh, Oluwaseun Adebayo Bamodu
Summary: The mediator complex subunit 10 (MED10) plays a critical role in the physiology and pathology of bladder cancer, and its dysregulation is associated with disease progression, metastasis, and recurrence.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Ming Wu, Wei-Lun Sun, Kang-Yun Lee, Cheng-Wei Lin, Po-Hao Feng, Hsiao-Chi Chuang, Shu-Chuan Ho, Kuan-Yuan Chen, Tzu-Tao Chen, Wen-Te Liu, Chien-Hua Tseng, Oluwaseun Adebayo Bamodu
Summary: This study in Taiwanese patients with COPD emphysema identified BMI, lnc-IL7R, PM2.5, PM10, and SO2 as predictors of disease severity and progression. Geospatial analysis showed that areas with high BMI and lnc-IL7R but low air pollutant levels had fewer COPD cases, while areas with high air pollutant levels but low BMI and lnc-IL7R had more cases and exacerbated conditions. The prediction model effectively differentiated patients with mild/no COPD from moderate/severe cases, with high precision.
Article
Biochemistry & Molecular Biology
Kai-Yi Tzou, Su-Wei Hu, Oluwaseun Adebayo Bamodu, Yuan-Hung Wang, Wen-Ling Wu, Chia-Chang Wu
Summary: This study evaluated the safety, efficacy, and duration of effect of Li-ESWT in Taiwanese males with ED, as well as explored disease-associated determinants of treatment success. The results showed that Li-ESWT is a safe and effective therapeutic modality for Taiwanese patients with ED, with uncontrolled hyperlipidemia and age over 45 years being independent negative predictors of treatment success.
Article
Multidisciplinary Sciences
Szu-Yi Chou, Oluwaseun Adebayo Bamodu, Wei-Ting Chiu, Chien-Tai Hong, Lung Chan, Chen-Chih Chung
Summary: This study evaluated the predictive validity of the CASPRI score in predicting neurological recovery in patients with cardiac arrest receiving targeted temperature management (TTM) and used artificial neural network algorithms to improve prediction performance. The CASPRI score was significantly associated with neurological outcome, and the generated ANN model showed good performance in predicting TTM neurological outcome.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Oluwaseun Adebayo Bamodu, Sheng-Ming Wu, Po-Hao Feng, Wei-Lun Sun, Cheng-Wei Lin, Hsiao-Chi Chuang, Shu-Chuan Ho, Kuan-Yuan Chen, Tzu-Tao Chen, Chien-Hua Tseng, Wen-Te Liu, Kang-Yun Lee
Summary: Despite the lack of actionable COPD pathognomonic molecular biomarkers, recent studies have suggested a potential role of lnc-IL7R in inflammation regulation and pulmonary function, showing its correlation with COPD progression and potential as a therapeutic target.
Article
Clinical Neurology
Cheng-Chang Yang, Oluwaseun Adebayo Bamodu, Lung Chan, Jia-Hung Chen, Chien-Tai Hong, Yi-Ting Huang, Chen-Chih Chung
Summary: This study developed an artificial neural network model to predict prolonged length of hospital stay after acute ischemic stroke by identifying risk factors and using parameters at the time of hospitalization. The key factors associated with prolonged length of stay included National Institutes of Health Stroke Scale scores at admission, atrial fibrillation, receiving thrombolytic therapy, history of hypertension, diabetes, and previous stroke. The proposed model can assist in clinically assessing the risk of prolonged hospitalization, informing decision-making, and developing individualized medical care plans for patients with acute ischemic stroke.
FRONTIERS IN NEUROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Roseline Dzekem Dine, Oluwaseun Adebayo Bamodu, Joseph Ntaganira
Summary: This study investigates health risk behavior among youth in Rwanda and its influence on HIV incidence. The results suggest that delaying the age of sexual debut can contribute to reducing HIV infection among Rwandan youth. Risky sexual behavior remains a major healthcare challenge in Rwanda, and interventions such as parental involvement and evidence-based healthcare policies can help mitigate the rising incidence of HIV among youth.
JOURNAL OF PUBLIC HEALTH-HEIDELBERG
(2023)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.