Article
Biochemistry & Molecular Biology
Qiang Chen, Shuqing Zhuang, Yilin Hong, Lingtao Yang, Peng Guo, Pingli Mo, Kesong Peng, Wengang Li, Nengming Xiao, Chundong Yu
Summary: The study found that PD-L1 and JMJD2D are frequently overexpressed in human CRC specimens and have a significant positive correlation. Knocking out JMJD2D in CRC cells weakens the expression of PD-L1, inhibits tumor growth, and increases the number and function of CD8(+) T cells in tumor infiltration. JMJD2D promotes the expression of PD-L1 by co-activating SP-1 to promote the expression of IFNGR1, thereby enhancing STAT3-IRF1 signaling. Pharmacological inhibition of JMJD2D can improve the therapeutic effect of PD-L1 antibody, increase the infiltration and function of CD8(+) T cells.
Article
Medicine, Research & Experimental
Xiaohui Xu, Yong Wu, Ke Yi, Yan Hu, Weiqun Ding, Chungen Xing
Summary: This study explored the role of IRF1 in the development and radiation sensitivity of colorectal cancer (CRC). It was revealed that increased expression of IRF1 inhibited cell proliferation, promoted apoptosis, and enhanced the sensitivity of CRC cells to X-ray irradiation. IRF1 upregulation was also found to increase the expression levels of interferon-induced proteins, further indicating its involvement in promoting radiosensitivity in CRC.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Xisheng Liu, Xiaole Meng, Xiao Peng, Qianlan Yao, Fangming Zhu, Zhongyi Ding, Hongze Sun, Xueni Liu, Dan Li, Ying Lu, Huamei Tang, Bin Li, Zhihai Peng
Summary: The global downregulation of miRNA expression, potentially due to defects in miRNA processing machinery, is a hallmark of human cancer. In colorectal cancer (CRC), downregulation of the key regulator of miRNA processing, Argonaute 2 (AGO2), has been found to promote epithelial-mesenchymal transition (EMT) and indicate poor prognosis. Knockdown of AGO2 in CRC cells enhanced migration, invasion, and metastasis, while integrated analyses revealed neuropilin 1 (NRP1) as a new substrate of AGO2 via miR-185-3p. Therapeutically targeting the AGO2/miR-185-3p/NRP1 axis may offer a potential treatment approach for CRC.
CELL DEATH & DISEASE
(2021)
Article
Environmental Sciences
Mengke Tang, Yifan Zhao, Yue Zhai, Yufan Zhang, Yalin Liu, Ting Liu, Jiaojiao Wu, Leyi He, Ye Yao, Peng Xue, Miao He, Yanyi Xu, Shaoqing Feng, Weidong Qu, Yubin Zhang
Summary: This study reveals the impact of Hg on the development of monocytes. Treatment with HgCl2 promotes the differentiation of monocytes and increases their quantity through activating certain signaling pathways. The increased monopoiesis by Hg is associated with an increased inflammatory status.
ENVIRONMENTAL POLLUTION
(2023)
Article
Cell & Tissue Engineering
Jian Zhang, Yao Lu, Yangming Mao, Yue Yu, Tianyu Wu, Wei Zhao, Yeqian Zhu, Pengcheng Zhao, Fengxiang Zhang
Summary: Exosomes derived from MSCs activated with IFN-gamma exhibit enhanced cardioprotective effects by upregulating miR-21 and directly targeting BTG2 to promote angiogenesis and reduce apoptosis.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Pathology
Nazila Mozammel, Mohammad Amini, Behzad Baradaran, Seyedeh Zahra Bahojb Mahdavi, Seyed Samad Hosseini, Ahad Mokhtarzadeh
Summary: MicroRNAs (miRNA) are a class of small non-coding RNAs that have significant impact on gene expression in human cancers. miR-145, a potential tumor suppressor miRNA, is downregulated in colorectal cancer and is involved in multiple processes such as cell proliferation, apoptosis, migration, and differentiation. It regulates tumor-specific signaling pathways, including KRAS and P53 signaling, through targeting various genes. This study aims to present recent findings on the functions of miR-145 and its involvement in colorectal cancer by interacting with multiple signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Lihua Wang, Nv Mu, Nina Qu
Summary: This study investigated the impact of miR-29b-3p gene promoter methylation on angiogenesis, invasion, and migration in human pancreatic cancer. The results showed a negative correlation between miR-29b expression and its promoter methylation level. Inhibiting DNMT1 had a suppressive effect on pancreatic cancer cell migration and invasion, while miR-29b reversed the promotive effect of DNMT1 on tumor cell properties.
Article
Medicine, Research & Experimental
Xijuan Chen, Yingqiang Liu, Qinglan Zhang, Baoxing Liu, Yan Cheng, Yonglei Zhang, Yanan Sun, Junqi Liu
Summary: miR-590-3p delivered through exosomes derived from CAFs enhances radioresistance in CRC by positively regulating the CLCA4-dependent PI3K/Akt signaling pathway.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Environmental Sciences
Zhongbi Peng, Xuemei Yang, Hua Zhang, Mingyue Yin, Yu Luo, Chun Xie
Summary: The research demonstrates that miR-29b-3p is involved in neuronal apoptosis triggered by the combination of fluorine and aluminum (FA) by targeting Dusp2. FA exacerbates NG108-15 cell apoptosis by increasing miR-29b-3p expression and inhibiting Dusp2.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Yifan Li, Jing Xun, Botao Wang, Yuan Ma, Lanqiu Zhang, Lei Yang, Ruifang Gao, Jun Guan, Tianyu Liu, Hejun Gao, Ximo Wang, Qi Zhang
Summary: The study found that miR-3065-3p is overexpressed in colorectal cancer and associated with poor prognosis. It promotes the stemness and metastasis of colorectal cancer. CRLF1, as a downstream target of miR-3065-3p, inhibits the stemness of colorectal cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jiaqiang Deng, Shengpeng Liu, Lili Zhao, Yan Li, Junyang Shi, Hua Zhang, Yuxuan Zhao, Liping Han, Huani Wang, Yan Yan, Hong Zhao, Fangdong Zou
Summary: miR-330-5p acts as a tumor suppressor in colorectal cancer by targeting SND1 expression, inhibiting tumor cell proliferation and migration, and enhancing sensitivity to chemotherapy drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Chaochao Xu, Lina Fan, Yifeng Lin, Weiyi Shen, Yadong Qi, Ying Zhang, Zhehang Chen, Lan Wang, Yanqin Long, Tongyao Hou, Jianmin Si, Shujie Chen
Summary: In this study, it was found that F. nucleatum plays a crucial role in promoting CRC metastasis by activating CCL20 and inducing M2 macrophage polarization. Moreover, the regulatory micro-RNA miR-1322 was identified to be involved in this process by regulating CCL20.
Article
Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Multidisciplinary Sciences
Enoch Kang, Sung Cheol Jung, Soo Kyung Nam, Yujun Park, Soo Hyun Seo, Kyoung Un Park, Heung-Kwon Oh, Duck-Woo Kim, Sung-Bum Kang, Hye Seung Lee
Summary: This study evaluated the prognostic potential of EMT-related miRNAs as biomarkers in colorectal cancer (CRC). The results showed that the tissue expression of miR-200c-3p and the plasma levels of miR-1290 were associated with poor prognosis.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Yuanzhou Zhang, Shunshun Liang, Bowen Xiao, Jingying Hu, Yechun Pang, Yuling Liu, Juan Yang, Junpin Ao, Lin Wei, Xiaoying Luo
Summary: This study shows that ErbB3/EGFR receptor tyrosine kinase activity is increased in colorectal cancer cells, and miR-323a-3p can directly target both ErbB3 and EGFR, promoting apoptosis in CRC cells. Furthermore, miR-323a-3p acts as a multi-ErbBs inhibitor, enhancing sensitivity to gefitinib and preventing acquired resistance.
CELL DEATH & DISEASE
(2022)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
