Phospho-ubiquitin: upending the PINK–Parkin–ubiquitin cascade

Mitophagy in yeast: Molecular mechanisms and physiological role

(2015) Tomotake Kanki et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular mechanisms underlying PINK1 and Parkin catalyzed ubiquitylation of substrates on damaged mitochondria

(2015) Fumika Koyano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PINK1/Parkin-mediated mitophagy in mammalian cells

(2015) Akinori Eiyama et al.   CURRENT OPINION IN CELL BIOLOGY

Expanding the ubiquitin code through post-translational modification

(2015) L. Herhaus et al.   EMBO REPORTS

Phosphorylated ubiquitin chain is the genuine Parkin receptor

(2015) Kei Okatsu et al.   JOURNAL OF CELL BIOLOGY

Unconventional PINK1 localization to the outer membrane of depolarized mitochondria drives Parkin recruitment

(2015) K. Okatsu et al.   JOURNAL OF CELL SCIENCE

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

(2015) Jin-Mi Heo et al.   MOLECULAR CELL

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

(2015) Michael Lazarou et al.   NATURE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

(2015) Tomokazu Murakawa et al.   Nature Communications

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Receptor-mediated mitophagy in yeast and mammalian systems

(2014) Lei Liu et al.   CELL RESEARCH

Organellophagy: Eliminating cellular building blocks via selective autophagy

(2014) Koji Okamoto   JOURNAL OF CELL BIOLOGY

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

Quantitative Proteomics Reveal a Feedforward Mechanism for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis

(2014) Alban Ordureau et al.   MOLECULAR CELL

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation

(2014) Yvette C. Wong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of Mitochondrial Polyubiquitin by PINK1 Promotes Parkin Mitochondrial Tethering

(2014) Kahori Shiba-Fukushima et al.   PLoS Genetics

PINK1 is degraded through the N-end rule pathway

(2013) Koji Yamano et al.   Autophagy

The protonophore CCCP interferes with lysosomal degradation of autophagic cargo in yeast and mammalian cells

(2013) Benjamin S Padman et al.   Autophagy

Parkin mitochondrial translocation is achieved through a novel catalytic activity coupled mechanism

(2013) Xinde Zheng et al.   CELL RESEARCH

Structure of the human Parkin ligase domain in an autoinhibited state

(2013) Tobias Wauer et al.   EMBO JOURNAL

A Dimeric PINK1-containing Complex on Depolarized Mitochondria Stimulates Parkin Recruitment

(2013) Kei Okatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

(2013) Masahiro Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding

(2013) Michael Lazarou et al.   JOURNAL OF CELL BIOLOGY

Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane

(2013) R. Goold et al.   JOURNAL OF CELL SCIENCE

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease

(2013) Donald E. Spratt et al.   Nature Communications

Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases

(2013) B.E. Riley et al.   Nature Communications

Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin

(2012) Michael Lazarou et al.   DEVELOPMENTAL CELL

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy

(2012) Kahori Shiba-Fukushima et al.   Scientific Reports

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

(2012) C. Kondapalli et al.   Open Biology

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids

(2011) Dawn M. Wenzel et al.   NATURE

What Genetics Tells us About the Causes and Mechanisms of Parkinson's Disease

(2011) Olga Corti et al.   PHYSIOLOGICAL REVIEWS

p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both

(2010) Derek Narendra et al.   Autophagy

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

(2010) Kei Okatsu et al.   GENES TO CELLS

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Identification of a Novel Zn2+-binding Domain in the Autosomal Recessive Juvenile Parkinson-related E3 Ligase Parkin

(2009) Ventzislava A. Hristova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Sorting Mechanism of p62 in Selective Autophagy

(2008) Yoshinobu Ichimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY