期刊
JOURNAL OF BIOCHEMISTRY
卷 161, 期 2, 页码 145-154出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvw085
关键词
autophagy; DNA; lysosome; nucleic acid; RNA
资金
- Japan Society for the Promotion of Science [24680038, 26111526, 16H05146, 16H01211]
- Japan Agency for Medical Research and Development (AMED)
- [26-8223]
- Grants-in-Aid for Scientific Research [16H01211, 16H05146, 26111526, 24680038] Funding Source: KAKEN
Cell metabolism can be considered as a process of serial construction and destruction of cellular components, both of which must be regulated accurately. In eukaryotic cells, a variety of cellular components are actively delivered into lysosomes/vacuoles, specialized compartments for hydrolysis of macromolecules. Such processes of 'self-eating' are called autophagy. Despite a wide variety of lysosomal/vacuolar hydrolases, much of the interest has been focused on the proteolytic functions of autophagy and less attention has been devoted to the degradation of other macromolecules such as nucleic acids. In this review, we focus on delivery and degradation of endogenous nucleic acids by autophagic systems, and discuss their molecular mechanisms and physiological/pathophysiological roles.
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