期刊
CELL REPORTS
卷 39, 期 4, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2022.110746
关键词
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类别
资金
- DFG [SPP 1464, CU217/2-1]
- BMBF [01GQ1406]
The cytoskeleton plays a crucial role in defining the dendrite morphologies of neurons. In this study focused on Drosophila larvae, the authors used computational modeling to investigate how actin-modulatory proteins (AMPs) contribute to defining neuronal types. They found that the main branches follow general models based on optimal wiring principles, while the short terminal branches require additional growth programs.
The cytoskeleton is crucial for defining neuronal-type-specific dendrite morphologies. To explore how the complex interplay of actin-modulatory proteins (AMPs) can define neuronal types in vivo, we focused on the class III dendritic arborization (c3da) neuron of Drosophila larvae. Using computational modeling, we reveal that the main branches (MBs) of c3da neurons follow general models based on optimal wiring principles, while the actin-enriched short terminal branches (STBs) require an additional growth program. To clarify the cellular mechanisms that define this second step, we thus concentrated on STBs for an in-depth quantitative description of dendrite morphology and dynamics. Applying these methods systematically to mutants of six known and novel AMPs, we revealed the complementary roles of these individual AMPs in defining STB properties. Our data suggest that diverse dendrite arbors result from a combination of optimal-wiring-related growth and individualized growth programs that are neuron-type specific.
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