A cerebellar origin of feedforward inhibition to the motor cortex in non-human primates

Voluntary movements are driven by coordinated activity across a large population of motor cortical neurons. Formation of this activity is controlled by local interactions and long-range inputs. How remote areas of the brain communicate with motor cortical neurons to effectively drive movement remains unclear. We address this question by studying the cerebellar-thalamocortical system. We find that thalamic input to the motor cortex triggers feedforward inhibition by contacting inhibitory cells via highly effective GluR2-lacking AMPA receptors and that, during task performance, the activity of parvalbumin (PV) and pyramidal cells exhibits relations comparable with movement parameters. We also find that the movement-related activity of PV inter neurons precedes firing of pyramidal cells. This counterintuitive sequence of events, where inhibitory cells are recruited more strongly and before excitatory cells, may amplify the cortical effect of cerebellar signals in a way that exceeds their sheer synaptic efficacy by suppressing other inputs.

Automated summary

In this study, the authors investigate how remote areas of the brain communicate with motor cortical neurons to drive movement. They find that thalamic input triggers feedforward inhibition by contacting inhibitory cells, and the movement-related activity of parvalbumin (PV) inter neurons precedes firing of other cells. These findings provide insights into the neural mechanisms underlying motor control.