期刊
JOURNAL OF AUTOIMMUNITY
卷 70, 期 -, 页码 52-62出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2016.03.017
关键词
Regulatory T cells; Nuclear factor of kappaB; RelA; Conditional gene targeting; Autoimmune disease
类别
资金
- NHMRC program [1016701, 1029822]
The properties of CD4(+) regulatory T cell (Treg) subsets are dictated by distinct patterns of gene expression determined by FOXP3 and different combinations of various transcription factors. Here we show the NF-kappa B transcription factor RelA is constitutively active in naive and effector Tregs. The conditional inactivation of Rela in murine FOXP3(+) cells induces a rapid onset, multi-focal autoimmune disease that depends on RelA being expressed in conventional T cells. In addition to promoting Treg lineage stability, RelA determines the size of the effector Treg population, a function influenced by the presence or absence of RelA in conventional T cells. These findings showing that RelA controls Treg stability and promotes the competitive fitness of effector Tregs highlight the importance of RelA activity in peripheral Treg induced tolerance. (C) 2016 Elsevier Ltd. All rights reserved.
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