Review
Oncology
Meysam Najaflou, Mehdi Shahgolzari, Ahmad Yari Khosroushahi, Steven Fiering
Summary: Tumor cell-derived extracellular vesicles (TEVs) play a significant role in tumor communication with the patient's physiology and can influence tumor regression or immune escape. Understanding the immunotherapeutic properties of TEVs and their manipulation for cancer treatment is a new research approach.
Review
Biochemistry & Molecular Biology
Aurelie Poncin, Concetta Elisa Onesti, Claire Josse, Delphine Boulet, Jerome Thiry, Vincent Bours, Guy Jerusalem
Summary: Studies have indicated that circulating eosinophil counts and tumor tissue infiltration by eosinophils are associated with prognosis in breast cancer patients, as well as with response to neoadjuvant chemotherapy in hormone receptor-negative/HER2-positive and triple negative breast cancer. Further research is needed to understand the exact mechanism by which eosinophils interact with breast cancer cells and to potentially identify new therapeutic targets.
Review
Immunology
Nela Friedlova, Filip Zavadil Kokas, Ted R. Hupp, Borivoj Vojtesek, Marta Nekulova
Summary: IFITM proteins play important roles in immune regulation and have effects on antiviral responses and tumorigenesis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
David W. Greening, Rong Xu, Anukreity Ale, Christoph E. Hagemeyer, Weisan Chen
Summary: Extracellular vesicles (EVs) serve as a means of communication and molecular transfer between cells, impacting host immune response. They can evade recognition and transfer functional components to target cells, influencing antigen presentation, immune activation, suppression, and surveillance. This review outlines the progress of EVs in immunorecognition and therapeutic intervention in cancer, including vaccine and targeted drug delivery, highlighting the use of EVs as immuno-EVs to enhance immunogenicity and tumor-killing function. The review emphasizes the need for direct assessment to improve immune response efficacy in the translation into clinical applications.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Immunology
Anne F. McGettrick, Luke A. J. O'Neill
Summary: The metabolite itaconate (ITA) and its derivatives have emerged as immunoregulators, with roles in limiting inflammation and affecting bacterial and viral infection. They target and inhibit multiple processes in macrophages, as well as multiple bacteria and viruses such as SARS-CoV2, Zika virus, and Influenza virus. ITA is important as pathogens can manipulate it for their own gain. Newly discovered isomers of ITA, mesaconate and citraconate, also have immunomodulatory effects. ITA continues to be a fascination with therapeutic potential in immune and inflammatory diseases.
CURRENT OPINION IN IMMUNOLOGY
(2023)
Review
Immunology
Kathrin Warner, Maryam Ghaedi, Douglas C. C. Chung, Nicolas Jacquelot, Pamela S. Ohashi
Summary: Innate lymphoid cells (ILCs), the innate counterparts of T cells, play a crucial role in immune responses and have a profound impact on diseases like cancer. ILCs can influence early tumor development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Huihai Yang, Lulu Wang, Jing Zhang
Summary: Cancer immunotherapy is an effective strategy for treating cancer, and herbal medicines and natural products play an important role in modulating tumor immunosurveillance.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Review
Cell Biology
Wooseok Seo, Aneela Nomura, Ichiro Taniuchi
Summary: The RUNX family of proteins plays a crucial role in development, immunity, and anti-tumor responses, and their dysregulation is often associated with tumorigenesis.
Review
Immunology
Marianna Nachef, Alaa Kassim Ali, Saeedah Musaed Almutairi, Seung-Hwan Lee
Summary: Cancer cells create a hostile tumor microenvironment that challenges immune cells' metabolic fitness. Enhancing immune cell metabolism, particularly by upregulating nutrient transporters like glucose and amino acid transporters, can strengthen tumor immunotherapy efforts. Amino acid transporters not only facilitate amino acid uptake but also play a role in sensing amino acid levels and activating key metabolic pathways essential for cell growth and proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Ting Jiang, Xisha Chen, Xingcong Ren, Jin-Ming Yang, Yan Cheng
Summary: This article discusses the important roles of autophagy in tumor cells, immune cells, and stromal cells in the context of tumor immunity, as well as the potential of combining autophagy-based therapy with immunotherapy as novel therapeutic approaches against cancer.
DRUG RESISTANCE UPDATES
(2021)
Article
Oncology
Elisabetta Vergani, Elena Daveri, Viviana Vallacchi, Laura Bergamaschi, Luca Lalli, Chiara Castelli, Monica Rodolfo, Licia Rivoltini, Veronica Huber
Summary: The impact of extracellular vesicles (EVs) on anti-tumor immune responses is still being explored. The small size and numerous subtypes of EVs, as well as the difficulty in determining their origin, pose challenges for investigation. While the study of cancer EVs has been facilitated by the existence of tumor cell lines, understanding the phenotypes and functions of immune cell EVs in this context is more complex. The emergence of immunotherapy with immune checkpoint inhibitors has increased the need to understand the role of EVs in immune activation and response, particularly in unraveling and preventing resistance in patients.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Plant Sciences
Shubing Chen, Yijing Xin, Ke Tang, You Wu, Ying Guo
Summary: The study identified nardosinone and aurantio-obtusin as anti-influenza agents through transcriptome analysis and in vitro evaluation. These compounds exerted their antiviral activities by reversing the expression of multiple informative genes in host cells. The combination of nardosinone and aurantio-obtusin may have a synergistic effect.
Review
Oncology
Avantika Tripathi, Anjali Kashyap, Greesham Tripathi, Joni Yadav, Rakhi Bibban, Nikita Aggarwal, Kulbhushan Thakur, Arun Chhokar, Mohit Jadli, Ashok Kumar Sah, Yeshvandra Verma, Hatem Zayed, Amjad Husain, Alok Chandra Bharti, Manoj Kumar Kashyap
Summary: The reversion of tumor cells to normal cells is on the brink of becoming a reality, thanks to advancements in molecular techniques, but customized precision techniques are still needed for further insights.
BIOMARKER RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Hongyong Huang, Yanmin Weng, Wen Tian, Xian Lin, Jian Chen, Lianxiang Luo
Summary: This review provides an overview of the mechanisms of pyroptosis, the relationship between the gasdermin family and pyroptosis, and the interplay between pyroptosis and anti-tumor immunity. Additionally, the potential implications of pyroptosis in cancer immunotherapy are discussed, along with future research possibilities and a novel approach to tumor treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Immunology
Marek Wagner, Shigeo Koyasu
Summary: Innate lymphoid cells (ILCs), enriched in barrier tissues like skin, play a role in immune pathways despite lacking antigen receptors found on T and B cells. They are crucial in controlling melanoma and potentially benefiting patients with skin malignancies through their therapeutic potential.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Muzammal Hussain, Yongzhi Lu, Yong-Qiang Liu, Kai Su, Jiancun Zhang, Jinsong Liu, Guang-Biao Zhou
PHARMACOLOGICAL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Yuyang Ding, Fei Tang, Xiaoqian Xue, Jinfeng Luo, Muzammal Hussain, Yanhui Huang, Zhen Wang, Hao Jiang, Zhengchao Tu, Jiancun Zhang
BIOORGANIC CHEMISTRY
(2019)
Review
Medicine, Research & Experimental
Muzammal Hussain, Dickson Adah, Muqddas Tariq, Yongzhi Lu, Jiancun Zhang, Jinsong Liu
Article
Biochemistry & Molecular Biology
Nasir Abbas, Anteneh Getachew, Kai You, Zahir Shah, Yan Chen, Jiawang Tao, Muzammal Hussain, Fan Yang, Yuanqi Zhuang, Yingying Xu, Yin-Xiong Li
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Hina Andleeb, Muzammal Hussain, Syeda Abida Ejaz, Jean Sevigny, Muhammad Farman, Masoom Yasinzai, Jiancun Zhang, Jamshed Iqbal, Shahid Hameed
BIOORGANIC CHEMISTRY
(2020)
Article
Biophysics
Omar Mukama, Jinghua Wu, Zhiyuan Li, Qiongxin Liang, Zhijian Yi, Xuewen Lu, Yujie Liu, Yumei Liu, Muzammal Hussain, Gaelle Guiewi Makafe, Jiaxin Liu, Ning Xu, Lingwen Zeng
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Chemistry, Analytical
Omar Mukama, Ting Yuan, Zhixu He, Zhiyuan Li, Jean de Dieu Habimana, Muzammal Hussain, Wei Li, Zhijian Yi, Qiongxin Liang, Lingwen Zeng
SENSORS AND ACTUATORS B-CHEMICAL
(2020)
Article
Chemistry, Multidisciplinary
Zhenxing Zhang, Chunqi Jia, Xiangtao Kong, Muzammal Hussain, Zhenyu Liu, Wanqing Liang, Ling Jiang, Hao Jiang, Junyan Ma
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2020)
Article
Multidisciplinary Sciences
Anteneh Getachew, Nasir Abbas, Kai You, Zhen Yang, Muzammal Hussain, Xinping Huang, Ziqi Cheng, Shenglin Tan, Jiawang Tao, Xiaorui Yu, Yan Chen, Fan Yang, Tingcai Pan, Yingying Xu, Guosheng Xu, Yuanqi Zhuang, FeiMa Wu, Yinxiong Li
Summary: The study found that serum amyloid A1 (SAA1) acts as a chemokine to recruit hepatic stellate cells (HSCs) towards injury loci through the TLR2 receptor, initiating PI3K-dependent signaling and regulating cell directional migration.
Review
Medicine, Research & Experimental
Anteneh Getachew, Muzammal Hussain, Xinping Huang, Yinxiong Li
Summary: Chronic liver diseases are a major global cause of mortality, with chronic alcohol abuse and high-fat diet contributing to severe liver disease. Understanding signaling pathways such as TLR2 in hepatic disease development is crucial, as targeting this pathway may alleviate disease-related functioning.
Article
Multidisciplinary Sciences
Muzammal Hussain, Yongzhi Lu, Muqddas Tariq, Hao Jiang, Yahai Shu, Shuang Luo, Qiang Zhu, Jiancun Zhang, Jinsong Liu
Summary: Skp1 overexpression promotes tumor growth, while reduced Skp1 activity is linked to genomic instability and neoplastic transformation. This study identifies Z0933M as a potent Skp1 inhibitor that disrupts SCF E3 ligase functioning and induces cell death. Z0933M could be a valuable tool for exploring Skp1 cancer biology and has implications for cancer therapy.
Article
Infectious Diseases
H. M. Adnan Hameed, Cuiting Fang, Zhiyong Liu, Yanan Ju, Xingli Han, Yamin Gao, Shuai Wang, Gift Chiwala, Yaoju Tan, Ping Guan, Jinxing Hu, Xiaoli Xiong, Jiacong Peng, Yongping Lin, Muzammal Hussain, Nanshan Zhong, Dmitry A. Maslov, Gregory M. Cook, Jianxiong Liu, Tianyu Zhang
Summary: This study investigated the prevalence of mutations in the rpoB gene of Mycobacterium tuberculosis clinical isolates and their association with rifampicin resistance. The results showed that mutations in the gene were common in rifampicin-resistant strains, with some mutations occurring in the RRDR region and others occurring outside the RRDR. GeneXpert MTB/RIF and sequencing analysis were effective in the rapid molecular diagnosis of rifampicin resistance. These findings are important for the early detection of tuberculosis and the recommendation of appropriate treatment regimens.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Biochemistry & Molecular Biology
Gaelle G. Makafe, Muzammal Hussain, Goverdhan Surineni, Yaoju Tan, Nai-Kei Wong, Mugweru Julius, Lanying Liu, Chiwala Gift, Huofeng Jiang, Yunxiang Tang, Jianxiong Liu, Shouyong Tan, Zhijun Yu, Zhiyong Liu, Zhili Lu, Cuiting Fang, Yang Zhou, Jiancun Zhang, Qiang Zhu, Jinsong Liu, Tianyu Zhang
CELL CHEMICAL BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Goverdhan Surineni, Yamin Gao, Muzammal Hussain, Zhiyong Liu, Zhili Lu, Chiranjibi Chhotaray, Md Mahmudul Islam, H. M. Adnan Hameed, Tianyu Zhang
Review
Biochemistry & Molecular Biology
Syed Niaz Ali Shah, Zahir Shah, Muzammal Hussain, Muzaffar Khan
BIOINORGANIC CHEMISTRY AND APPLICATIONS
(2017)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.
