Article
Urology & Nephrology
Davide Bolignano, Evangelia Dounousi, Pierangela Presta, Marta Greco, Anila Duni, Giuseppina Crugliano, Charalambos Pappas, Ethymios Pappas, Francesco Dragone, Lampros Lakkas, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino
Summary: This study found that Omentin-1 is involved in iron balance regulation in patients undergoing chronic hemodialysis (HD), and it may serve as a candidate biomarker for diagnosing and managing altered iron conditions in these patients.
CLINICAL KIDNEY JOURNAL
(2022)
Review
Transplantation
Anatole Besarab, Tilman B. Drueke
Summary: This passage discusses the physiological review of iron metabolism and diagnostic tests for iron status in patients without CKD or inflammation. It then delves into the dysregulation of iron metabolism in CKD, particularly the impact of the inflammatory state associated with CKD progression.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Nutrition & Dietetics
Cenqin Liu, Yishu Chen, Zhixin Zhang, Jiarong Xie, Chaohui Yu, Lei Xu, Youming Li
Summary: This study used a two-sample Mendelian randomization to examine the relationship between iron status and non-alcoholic fatty liver disease (NAFLD). The results showed that higher levels of serum ferritin, iron, and transferrin saturation (TSAT) were associated with an increased risk of NAFLD. Conversely, NAFLD had minimal effects on iron status. These findings suggest the potential benefits of iron-related therapy for NAFLD treatment.
Review
Medicine, General & Internal
Patrice Cacoub, Gabriel Choukroun, Alain Cohen-Solal, Elisabeth Luporsi, Laurent Peyrin-Biroulet, Katell Peoc'h, Valerie Andrieu, Sigismond Lasocki, Herve Puy, Jean-Noel Trochu
Summary: Iron deficiency is common in patients with chronic inflammatory diseases and has a negative impact on their health. Serum ferritin and transferrin saturation are effective biomarkers for assessing iron deficiency. Screening for iron parameters is important due to the non-specific symptoms of iron deficiency.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Antonella Giliberti, Annalisa Curcio, Nicola Marchitto, Luca Di Lullo, Fulvia Paolozzi, Fabiana Nano, Michele Pironti, Gianfranco Raimondi
Summary: The study investigated the efficacy of a new oral iron formulation in patients with moderate CKD and functional IDA, demonstrating that the formulation based on ferric sodium EDTA showed superior efficacy in improving iron blood parameters and reducing inflammatory status compared to other oral iron sources.
Review
Nutrition & Dietetics
Hana Manceau, Jerome Ausseil, Damien Masson, Jean-Paul Feugeas, Bernard Sablonniere, Regis Guieu, Herve Puy, Katell Peoc'h
Summary: Iron deficiency is a significant comorbidity of heart failure, often leading to rehospitalizations and reduced survival rates, however, correction with iron supplementation can improve functional capacity and quality of life in patients.
Article
Biochemistry & Molecular Biology
Chukwuma A. Chukwu, Helen Gilbody, Olivia Wickens, Craig Carroll, Sunil Bhandari, Philip A. Kalra
Summary: This study aimed to investigate the factors affecting the erythropoietic response to parenteral iron in iron-deficient anaemic patients. It found that the nature of iron deficiency, rather than the severity of CKD, has a greater impact on Hb response to intravenous iron, with a diminished response seen in patients with functional iron deficiency regardless of the degree of renal impairment.
Article
Nutrition & Dietetics
Herve Lobbes, Stephane Durupt, Sabine Mainbourg, Bruno Pereira, Raphaele Nove-Josserand, Isabelle Durieu, Quitterie Reynaud
Summary: Iron deficiency prevalence in adult patients with cystic fibrosis is 44.2%, and it is significantly associated with female gender, younger age, lower body mass index, and Pseudomonas aeruginosa colonization.
Article
Medicine, General & Internal
Daniela Nicotra, Rakefet Arieli, Noam Redlich, Dalya Navot-Mintzer, Naama W. Constantini
Summary: The aim of this study was to assess the prevalence of iron deficiency and iron deficiency anemia among male adolescent athletes participating in non-calorie-restricting sports, and compare it with female athletes of the same age and sports. Data from basketball and football players aged 11-18 were analyzed, and it was found that non-anemic iron deficiency is highly prevalent among adolescent males playing ball games. Mild and moderate iron deficiency were significantly higher among females. Screening for hemoglobin and serum ferritin is recommended for young athletes of both genders and in all sports.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Monika Kasztura, Liliana Kiczak, Urszula Paslawska, Jacek Bania, Adrian Janiszewski, Alicja Tomaszek, Maciej Zacharski, Agnieszka Noszczyk-Nowak, Robert Paslawski, Aleksandra Tabis, Piotr Kuropka, Piotr Dziegiel, Piotr Ponikowski
Summary: The distribution and metabolism of iron in the pathogenesis of heart failure need to be clarified. In a porcine model of heart failure, we found that liver congestion overwhelms its capacity to recycle iron, leading to trapped iron in the liver. Additionally, there is a decrease in bioavailable iron stores in the liver and a drop in myocardial iron stores. This results in down-regulated iron availability for systemic and cardiac needs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cole A. Guggisberg, Juyoung Kim, Jaekwon Lee, Xiaoli Chen, Moon-Suhn Ryu
Summary: Macrophages recycle iron from erythrocytes and NCOA4 regulates ferritinophagy and iron release. NCOA4 has functional association with immune response.
Article
Nutrition & Dietetics
Guillermo Bastida, Claudia Herrera-de Guise, Alicia Algaba, Yolanda Ber Nieto, Jose Manuel Soares, Virginia Robles, Fernando Bermejo, Esteban Saez-Gonzalez, Fernando Gomollon, Pilar Nos
Summary: This study showed that sucrosomial iron (SI) treatment is effective and well-tolerated for patients with iron deficiency anemia (IDA) and inflammatory bowel disease (IBD) who are intolerant to oral iron salts. It significantly increased hemoglobin levels and improved quality of life for patients.
Article
Medicine, General & Internal
Roberta Loveikyte, Menno Boer, Catharina N. van der Meulen, Rinze W. F. ter Steege, Greetje Tack, Johan Kuyvenhoven, Bindia Jharap, My K. Vu, Lauran Vogelaar, Rachel L. West, Sander van der Marel, Tessa E. H. Romkens, Zlatan Mujagic, Frank Hoentjen, Adriaan A. van Bodegraven, Fiona D. M. van Schaik, Annemarie C. de Vries, Gerard Dijkstra, Andrea E. Van der Meulen-de Jong
Summary: This study assessed the prevalence of iron deficiency (ID) and anemia in Dutch outpatients with Inflammatory Bowel Disease (IBD) and compared the routine ID(A) management among medical professionals to the treatment guidelines. The findings showed that one in five IBD patients suffered from anemia, and most medical professionals treated anemic ID with standard doses of oral or intravenous iron while non-anemic ID was often overlooked.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pathology
Kay Weng Choy, Gorkem Sezgin, Nilika Wijeratne, John Calleja, Rachelle Liwayan, Geetha Rathnayake, Robert McFarlane, Alan McNeil, James C. G. Doery, Zhong Lu, Corey Markus, Tze Ping Loh
Summary: This study evaluated the analytical bias of five widely used commercial ferritin assays in Australia and derived functional reference limits for Siemens, Abbott, and Ortho methods. The results showed significant biases among different assays, which may affect the accuracy of ferritin measurements. More research is needed to address the commutability issues between these methods.
Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Letter
Urology & Nephrology
Maxime Touzot, Thibaud Lefebvre, Catherine Maheas, Katell Peoc'h, Pablo Urena-Torres, Christophe Ridel, Herve Puy, Zoubida Karim
CLINICAL KIDNEY JOURNAL
(2022)
Review
Medicine, General & Internal
Patrice Cacoub, Gabriel Choukroun, Alain Cohen-Solal, Elisabeth Luporsi, Laurent Peyrin-Biroulet, Katell Peoc'h, Valerie Andrieu, Sigismond Lasocki, Herve Puy, Jean-Noel Trochu
Summary: Iron deficiency is common in patients with chronic inflammatory diseases and has a negative impact on their health. Serum ferritin and transferrin saturation are effective biomarkers for assessing iron deficiency. Screening for iron parameters is important due to the non-specific symptoms of iron deficiency.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Olivier Deckmyn, Thierry Poynard, Pierre Bedossa, Valerie Paradis, Valentina Peta, Raluca Pais, Vlad Ratziu, Dominique Thabut, Angelique Brzustowski, Jean-Francois Gautier, Patrice Cacoub, Dominique Valla
Summary: In patients with non-alcoholic fatty liver disease (NAFLD), type 2 diabetes mellitus (T2DM) may exacerbate the associations between alpha-2 macroglobulin (A2M), apolipoprotein Al (ApoA1), haptoglobin, liver fibrosis, inflammation, and COVID-19.
Review
Nutrition & Dietetics
Hana Manceau, Jerome Ausseil, Damien Masson, Jean-Paul Feugeas, Bernard Sablonniere, Regis Guieu, Herve Puy, Katell Peoc'h
Summary: Iron deficiency is a significant comorbidity of heart failure, often leading to rehospitalizations and reduced survival rates, however, correction with iron supplementation can improve functional capacity and quality of life in patients.
Article
Multidisciplinary Sciences
Sebastien Tanaka, Christian De Tymowski, Jules Stern, Donia Bouzid, Nathalie Zappella, Aurelie Snauwaert, Tiphaine Robert, Brice Lortat-jacob, Alexy Tran-dinh, Pascal Augustin, Anne Boutten, Parvine Tashk, Katell Peoc'h, Olivier Meilhac, Philippe Montravers
Summary: The study found that low lipoprotein concentrations were associated with mortality in septic patients, while sepsis-associated liver dysfunction was linked to higher mortality rates. In patients with liver dysfunction, there was a lower HDL-C concentration, but it did not impact mortality rates.
Article
Infectious Diseases
Etienne de Montmollin, Katell Peoc'h, Mehdi Marzouk, Stephane Ruckly, Paul-Henri Wicky, Juliette Patrier, Pierre Jaquet, Romain Sonneville, Lila Bouadma, Jean-Francois Timsit
Summary: This study aimed to evaluate MR-proADM as a prognostic biomarker and marker of bacterial superinfection in severe SARS-CoV-2 infection. The results showed that MR-proADM is a good predictor of outcome in severe SARS-CoV-2 infection and could be a useful tool to assess bacterial superinfection in COVID-19 patients.
Editorial Material
Medical Laboratory Technology
Katell Peoc'h
ANNALES DE BIOLOGIE CLINIQUE
(2023)
Article
Medical Laboratory Technology
Alexandre Raynor, Carmen Stefanescu, Arnaud Bruneel, Herve Puy, Katell Peoc'h, Hana Manceau
Summary: We present the case of a 42-year-old woman with chronic enteropathy and acquired atransferrinemia. Despite the absence of detectable serum transferrin, the patient only exhibited mild anaemia, and her haemoglobin concentration remained stable throughout the two-month hospitalization. The acquired atransferrinemia was believed to be secondary to chronic undernutrition, inflammation, and liver failure.
Article
Anesthesiology
M. Leger, J. Auchabie, M. Ferrandiere, E. Parot-Schinkel, M. Campfort, E. Rineau, S. Lasocki
Summary: Anaemia is common and associated with poor outcomes during and after critical illness. The use of erythropoietin to treat such anaemia is controversial. In this study, the feasibility of a large multicentre randomised controlled trial of erythropoietin in ICU patients with anaemia was evaluated.
Article
Medical Laboratory Technology
Elodie Lebredonchel, Alexandre Raynor, Arnaud Bruneel, Katell Peoch, Andre Klein
Summary: In this case, a 39-year-old male of Tamil ethnicity had extremely elevated (20%) carbohydrate-deficient transferrin (CDT) levels measured by capillary electrophoresis. However, further investigation revealed a genetic variant on the TF gene, causing half of the patient's transferrin proteins to lack a complete glycan chain despite no alcohol consumption, explaining the discrepancy between the techniques used. This case highlights the importance of comparing laboratory results with clinical descriptions, performing glycoforms profile analysis, and confirming intriguing results with another technique in a specialized laboratory.
CLINICA CHIMICA ACTA
(2023)
Article
Rheumatology
Alexandre Le Joncour, Paul Regnier, Anna Maciejewski-Duval, Erwan Charles, Stephane Barete, Pierre Fouret, Michelle Rosenzwajg, David Klatzmann, Patrice Cacoub, David Saadoun
Summary: This study aimed to investigate the effect of phosphodiesterase 4 (PDE4) inhibition on neutrophil activation in Behcet's disease (BD). The results showed that surface markers, reactive oxygen species (ROS) production, and neutrophil extracellular traps (NETs) production were upregulated in BD patient neutrophils. Inhibition of PDE4 significantly reduced neutrophil surface activation markers, ROS production, NETosis, and genes and pathways related to innate immunity, intracellular signaling, and chemotaxis.
ARTHRITIS & RHEUMATOLOGY
(2023)
Review
Medicine, General & Internal
Morgane Joubert, Anne-Claire Desbois, Fanny Domont, Amine Ghembaza, Alexandre Le Joncour, Adrien Mirouse, Georgina Maalouf, Mathilde Leclercq, Sarah Touhami, Patrice Cacoub, Bahram Bodaghi, David Saadoun
Summary: Uveitis is a common and significant complication in Behcet's disease, with a high risk of blindness. It commonly presents as panuveitis, with bilateral involvement occurring after 2 years on average. Prompt management is crucial to achieve remission and preserve vision. Biologic therapies have revolutionized the treatment of uveitis in Behcet's disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Anesthesiology
Maxime J. J. Fleury, Claire Nicolleau, Guillaume Bouhours, Mathieu Conte, Ludovic Martin, Sigismond Lasocki, Maxime Leger
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Nutrition & Dietetics
Salma Fourati, Annick Hamon, Rita Daclat, Joe-Elie Salem, Katell Peoc'h, Johanne Le Beyec, Francisca Joly, Jean-Marc Lacorte
Summary: This study found that ApoB-48 protein could be used as a marker to assess intestinal function in patients with short bowel syndrome. There was a positive correlation between ApoB-48 and residual small bowel length, and lower levels of ApoB-48 were observed in patients dependent on parenteral nutrition.