Review
Food Science & Technology
Domenico Sergi, Hakim Boulestin, Fiona M. Campbell, Lynda M. Williams
Summary: AGEs are a group of molecules produced through non-enzymatic reactions, implicated in complications of diabetes and metabolic health, contributing to the development of type 2 diabetes and obesity.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Chemistry, Applied
Zhaoqing Tian, Shasha Chen, Yiheng Shi, Panpan Wang, Yongning Wu, Guoliang Li
Summary: Advanced glycation end products (AGEs) are formed through chemical reactions of amino acids, peptides, proteins, and ketones at normal or heated non-enzymatic conditions. The intake of dietary AGEs is linked to the development of various chronic diseases, and their safety and health risks have garnered significant attention. This review provides an overview of the production, bio-transport, detection technologies, and physiological toxicity of dietary AGEs, as well as discusses strategies to inhibit their generation. Future opportunities and challenges in the detection, toxicity, and inhibition of dietary AGEs are also highlighted.
Review
Food Science & Technology
Jingnan Lu, Mingyu Li, Yousheng Huang, Jianhua Xie, Mingyue Shen, Mingyong Xie
Summary: AGEs and NAs are common hazards in meat products, formed during processing and storage, and may be related to diseases. The formation of AGEs and NAs is influenced by the composition and processing methods of meat products, and antioxidants can effectively inhibit their production.
Review
Immunology
Martina Maurelli, Paolo Gisondi, Giampiero Girolomoni
Summary: Advanced glycation end products (AGEs) are biologically active compounds that react with proteins to generate reactive aldehydes. They accumulate in tissues during ageing and in various metabolic and inflammatory disorders such as type 2 diabetes, obesity, cardiovascular diseases, chronic renal insufficiency, and psoriasis. The interaction of AGEs with their receptors (RAGEs) leads to cellular signaling, oxidative stress, and activation of inflammatory mediators. AGEs may play a pathogenic role in the intersection of inflammatory and metabolic diseases and could be a potential target for therapeutic strategies.
Article
Agriculture, Dairy & Animal Science
Pornsucha Palaseweenun, Esther A. Hagen-Plantinga, J. Thomas Schonewille, Gerrit Koop, Claire Butre, Melliana Jonathan, Peter A. Wierenga, Wouter H. Hendriks
Summary: The study revealed a correlation between dietary AGEs and the urinary excretion of AGEs in pet dogs and cats, indicating endogenous formation of these compounds under physiological conditions in both species.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Jinluan Chen, Djawad Radjabzadeh, Carolina Medina-Gomez, Trudy Voortman, Joyce B. J. van Meurs, M. Arfan Ikram, Andre G. Uitterlinden, Robert Kraaij, M. Carola Zillikens
Summary: This study investigated the association between dietary advanced glycation end products (AGEs) and gut microbiota, as well as the relationship between skin AGEs and gut microbiota. The results showed that dietary AGEs were not associated with the diversity or dissimilarity of gut microbiota, but were associated with the abundance of certain bacterial genera. Skin AGEs were associated with gut microbiota composition and metabolic pathways. These findings suggest a potential interaction between gut microbiota and AGE metabolism.
Review
Nutrition & Dietetics
Nelia P. Mendes, Priscila V. M. Ribeiro, Rita C. G. Alfenas
Summary: This systematic review explores the effect of dietary fat on markers of glycation and reveals that consumption of a Mediterranean diet rich in MUFAs and low in dietary AGEs, as well as supplementation with omega-3 PUFAs, can reduce AGEs and modulate the expression of AGE receptors. These findings suggest that increasing the consumption of MUFAs and omega-3 PUFAs while reducing the intake of saturated fatty acids can have beneficial effects on glycation markers, thereby preventing and controlling chronic diseases.
Review
Endocrinology & Metabolism
Bowen Wang, Deepak Vashishth
Summary: Hyperglycemia and oxidative stress in diabetes and aging lead to excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOEs disrupt bone turnover and deteriorate bone quality through alterations of organic matrix, mineral, and water content. This review explains the accumulation and impact of AGEs/AGOEs in bone, as well as their targeting in preclinical and clinical investigations for the management of diabetic, osteoporotic, and insufficiency fractures.
Article
Endocrinology & Metabolism
Komal Waqas, Jinluan Chen, T. Lu, B. C. J. van der Eerden, Fernando Rivadeneira, Andre G. Uitterlinden, Trudy Voortman, M. Carola Zillikens
Summary: A study investigated the relationship between dietary intake of carboxymethyllysine (dCML) and risk of sarcopenia and frailty. The researchers found an association between dAGEs and prevalent sarcopenia, but no association with incident sarcopenia or frailty.
Article
Cardiac & Cardiovascular Systems
Alain K. Koyama, Meda E. Pavkov, Yanjue Wu, Karen R. Siegel
Summary: This study aimed to investigate the association between dietary advanced glycation end products (AGEs) intake and mortality. The analysis of 5,474 adults with diabetes showed that higher AGEs intake was associated with lower concordance to dietary guidelines. However, there was no significant association between AGEs intake and all-cause mortality.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Misganaw Asmamaw Mengstie, Endeshaw Chekol Abebe, Awgichew Behaile Teklemariam, Anemut Tilahun Mulu, Melaku Mekonnen Agidew, Muluken Teshome Azezew, Edgeit Abebe Zewde, Assefa Agegnehu Teshome
Summary: Hyperglycemia leads to protein glycation and accumulation of advanced glycation end products, which play a significant role in the development of diabetes complications. Their contribution occurs through receptor-mediated signaling cascade or direct extracellular matrix destruction.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Toshiyuki Oshitari
Summary: Diabetic retinopathy is a tissue-specific neurovascular impairment in diabetic patients that affects the retina. Advanced glycation end-products (AGEs) are a major pathological factor causing neurovascular coupling impairments. Mechanisms such as AGE-receptor axis, reactive oxygen species, inflammation, and cell death pathways contribute to the impairment of neurovascular units. Neuronal cell death is directly associated with vision reduction in diabetic patients, highlighting the need for neuroprotective therapies targeting AGEs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Matheus Thomaz Nogueira Silva Lima, Michael Howsam, Pauline M. Anton, Carine Delayre-Orthez, Frederic J. Tessier
Summary: Chronic Low-Grade Inflammation (CLGI) is characterized by continuous activation of inflammation mediators associated with metabolic diseases, often linked to overconsumption of Advanced Glycation End-Products (AGEs) and high-calorie diets. Murine models have helped elucidate the physiological effects of diet-induced CLGI, particularly in relation to metabolic endotoxemia and gut microbiota remodeling. Further research is needed to identify the best biomarkers for CLGI studies and to determine the translational relevance to humans.
Review
Biochemistry & Molecular Biology
Mariyam Khalid, Georg Petroianu, Abdu Adem
Summary: Persistent hyperglycemia in type 2 diabetes mellitus triggers a glycation reaction, resulting in the formation of AGEs. Binding of AGEs with its receptor RAGE activates various signaling pathways, leading to oxidative stress, inflammation, compromised insulin signaling, metabolic disturbances, pancreatic beta cell toxicity, and epigenetic modifications. This review summarizes the sources of AGEs, their role in metabolic dysfunction, and the AGEs/RAGE signaling cascade in type 2 diabetes mellitus and its associated complications.
Review
Nutrition & Dietetics
Nathan M. D'Cunha, Domenico Sergi, Melissa M. Lane, Nenad Naumovski, Elizabeth Gamage, Anushri Rajendran, Matina Kouvari, Sarah Gauci, Thusharika Dissanayka, Wolfgang Marx, Nikolaj Travica
Summary: This review examines the relationship between advanced glycation end products (AGEs) and neurocognitive and mental health disorders. Studies show that elevated circulating AGEs are associated with poorer cognitive function and increased risk of developing dementia, while higher skin AGE accumulation may be associated with mental disorders. The effects of AGEs are mediated by increased oxidative stress and neuroinflammation, and reducing dietary intake of AGEs may improve neurological and mental disorder outcomes.
Article
Urology & Nephrology
Kinsuk Chauhan, Pattharawin Pattharanitima, Federica Piani, Richard J. Johnson, Jaime Uribarri, Lili Chan, Steven G. Coca
Summary: This study found that higher serum UA levels were independently associated with AKI, MAKE, and in-hospital mortality in a dose-dependent manner in patients admitted to the hospital for COVID-19. Hyperuricemia was also associated with higher procalcitonin and troponin I levels.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
Laili Soleimani, Michal Schnaider Beeri, Anthony Heymann, Abigail Livny, Orit Lesman-Segev, Hung-Mo Lin, Yuxia Ouyang, Ramit Ravona-Springer
Review
Urology & Nephrology
Katherine R. Tuttle, Rajiv Agarwal, Charles E. Alpers, George L. Bakris, Frank C. Brosius, Peter Kolkhof, Jaime Uribarri
Summary: Diabetic kidney disease is a global burden that increases the risk of kidney failure and cardiovascular events. There is a need to understand the molecular mechanisms of the disease and find new therapies. Inflammatory and fibrotic mediators play important roles in the pathophysiology of the disease. Recent clinical trials have shown promising drug therapies and dietary strategies for treating diabetic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Marzuq Billah, Jaime Uribarri, Elliot Charen, Shuchita Sharma
Summary: This study presents a series of peritonitis cases with unusual organisms in a single home dialysis center in New York City. These uncommon cases highlight the importance of various elements that can lead to peritonitis.
SEMINARS IN DIALYSIS
(2023)
Article
Urology & Nephrology
Maryanne Y. Sourial, Anirudh Gone, Jaime Uribarri, Vesh Srivatana, Shuchita Sharma, Daniil Shimonov, Michael Chang, Wenzhu Mowrey, Rochelle Dalsan, Kaltrina Sedaliu, Swati Jain, Michael J. Ross, Nina Caplin, Wei Chen
Summary: During the peak of the COVID-19 pandemic, the use of peritoneal dialysis (PD) for the treatment of acute kidney injury (AKI) was not associated with worse clinical outcomes compared to extracorporeal dialysis.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Hana Kahleova, Tatiana Znayenko-Miller, Jaime Uribarri, Richard Holubkov, Neal D. Barnard
Summary: This study aimed to assess the effects of a low-fat plant-based diet on dietary AGEs and their association with body weight, body composition, and insulin sensitivity. The results showed that a low-fat plant-based diet decreased dietary AGEs and this decrease was associated with changes in body weight, body composition, and insulin sensitivity, independent of energy intake.
OBESITY SCIENCE & PRACTICE
(2023)
Editorial Material
Nutrition & Dietetics
Alicia Leikin-Frenkel, Michal Schnaider Beeri, Itzik Cooper
Summary: Cognitive decline in Alzheimer's disease is primarily attributed to protein deposits, but growing evidence suggests that brain lipids and blood-brain barrier dysfunction also play a crucial role. This study investigates the relationship between ApoE4 genotype and altered fatty acid composition in the BBB, and explores the potential therapeutic role of alpha linolenic acid in improving BBB function, particularly in ApoE4 carriers.
Editorial Material
Nutrition & Dietetics
Mona S. Calvo, Jaime Uribarri
JOURNAL OF THE ACADEMY OF NUTRITION AND DIETETICS
(2023)
Letter
Medicine, General & Internal
Jaime Uribarri, Lorena Drago, Arnold R. R. Eiser
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Geriatrics & Gerontology
Hana Kahleova, Tatiana Znayenko-Miller, Jaime Uribarri, Natalie Schmidt, Sinjana Kolipaka, Ellen Hata, Danielle N. Holtz, Macy Sutton, Richard Holubkov, Neal D. Barnard
Summary: This study investigated the potential association between modifications to the intake of dietary advanced glycation end-products (AGEs) and the frequency and severity of postmenopausal hot flashes. The study found that adhering to a low-fat vegan diet was significantly associated with a reduction in the frequency and severity of hot flashes in postmenopausal women, independent of changes in energy intake and weight loss.
Review
Cell Biology
Manuel Portero-Otin, M. Pia de la Maza, Jaime Uribarri
Summary: Insulin resistance is commonly observed during aging and is a major factor in chronic nontransmissible diseases. Diet, particularly the intake of advanced glycation end products (AGEs), plays a significant role in causing insulin resistance. Clinical trials and animal studies suggest that reducing dietary AGE intake can improve insulin resistance.
Review
Nutrition & Dietetics
Mona S. Calvo, Elizabeth K. Dunford, Jaime Uribarri
Summary: The consumption of ultra-processed food (UPF) is increasing, and numerous epidemiological studies have found a link between high UPF consumption and serious health issues like cardiovascular disease. This review focuses on the potential role of inorganic phosphate additives, commonly found in UPF, in contributing to negative cardiorenal effects. Inorganic phosphates are rapidly absorbed and can lead to negative effects on the heart and kidneys through calcification and the release of mineral-regulating hormones. The precise extent of the association between inorganic phosphate additives and health outcomes needs further investigation.
Letter
Urology & Nephrology
Osama El Shamy, Aditya Jain, Marzuq Billah, Shuchita Sharma, Jaime Uribarri