Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Oncology
Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy, Douglas W. Sborov, Paul J. Shami
Summary: This study aimed to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced solid tumors and liver involvement. Some toxicities were observed in the treatment group, but overall tolerability was good, with an increase in S-glutathionylation of serum proteins following treatment.
Article
Chemistry, Multidisciplinary
Zeqian Huang, Yong Luo, Tao Zhang, Yaqing Ding, Meixu Chen, Jie Chen, Qiuxing Liu, Yanjuan Huang, Chunshun Zhao
Summary: Selective activation of prodrugs is important for reducing the side effects of disease treatment. In this study, a metal-carrying prochelator concept was proposed, which can co-carry a metal ion and chelator within a small-molecule compound and synthesize a bioactive metal complex for targeted therapy. A H2O2-responsive small-molecule prochelator, DPBD, was designed and showed potent antitumor efficacy with low systemic toxicity by releasing chelator DTC and chelating Cu2+.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Marwa M. Abu-Serie, Marwa Eltarahony
Summary: A novel nanocomplex of DS-CuO NPs was prepared, showing high stability and potent selective anticancer activity against human breast, lung, and liver cancer cells with low inhibitory concentration. This nanocomplex exhibited better anticancer effect and cellular uptake, as well as prooxidant effect-mediated apoptosis and anti-metastatic potential. These findings suggest that the novel nanocomplex may improve the therapeutic index of the conventional DS-Cu complex and warrant further investigation for future clinical applications.
CANCER NANOTECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haixian Zhang, Feifei Song, Caihong Dong, Luodan Yu, Cai Chang, Yu Chen
Summary: This study proposed a therapeutic construction with high biosafety and efficiency for synergistic tumor-activated and photothermal-augmented chemotherapy in breast tumor eradication both in vitro and in vivo, achieving remarkable results in tumor elimination.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Vinodh Kannappan, Misha Ali, Benjamin Small, Gowtham Rajendran, Salena Elzhenni, Hamza Taj, Weiguang Wang, Q. Ping Dou
Summary: Copper plays a key role in cancer progression and copper-based complexes are being investigated as novel anticancer drugs. The combination of DSF with copper has shown great anticancer potential, but DSF has proven unsuccessful in clinical trials, likely due to poor stability of the currently used oral version of DSF.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Han-Xiao Tang, Jian-Ting Zhang, Chen-Guang Liu, Shi-Bin Wang, Xiao-Ke Zheng, Ai-Zheng Chen
Summary: In this study, a simple and efficient strategy was developed for the controllable loading of hydrophobic DSF into Cu2+-doped mesoporous silica nanoparticles (Cu-MSN) using supercritical CO2 technology. The DSF-loaded Cu-MSN exhibited high anticancer activity in vitro and in vivo, indicating its potential in cancer therapy.
JOURNAL OF CO2 UTILIZATION
(2023)
Article
Engineering, Biomedical
Yao Lu, Qingqing Pan, Wenxia Gao, Yuji Pu, Kui Luo, Bin He, Zhongwei Gu
Summary: Disulfiram (DSF) has been used as an alcoholism drug for 70 years and has recently gained attention for its anticancer activity. However, the oral delivery of DSF in clinical settings has not yielded satisfactory outcomes, calling for a deeper understanding of its mechanisms and limitations. This review provides a critical summary of the molecular biological anticancer mechanisms of DSF/Cu2+ and explains the challenges of oral DSF delivery in clinical oncology. It also highlights recent advances in DSF/Cu2+ delivery strategies and emerging treatment regimens for cancer therapy.
Article
Infectious Diseases
Claire N. Shanholtzer, Cameron Rice, Katherine Watson, Hannah Carreon, Timothy E. Long
Summary: This study evaluated the impact of copper on the antifungal activity of disulfiram against fluconazole-resistant Candida species. The results showed that copper addition enhanced the inhibitory effects of disulfiram on Candida cultures, but it also antagonized the fungicidal activity of disulfiram.
Article
Engineering, Environmental
Ying Peng, Peng Liu, Jinsong Ding, Wenhu Zhou
Summary: This study explores the potential of combining DSF, Cu2+, and Ca2+ as a promising approach for treating tumors. By developing biomineralized nanoparticles that can release DTC, Cu2+, and Ca2+ in response to the acidic tumor microenvironment, the study demonstrates the amplified anti-tumor effects achieved through in-situ CuET generation and calcium overload.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Inorganic & Nuclear
Wenting Guo, Tongxi Ji, Yunhu Deng, Jia Liu, Yantong Gou, Wenkui Dong
Summary: Chemodynamic therapy (CDT) is a treatment method that utilizes Fenton catalysts to convert intracellular H2O2 into toxic hydroxyl radicals ((OH)-O-center dot) to kill cancer cells. However, the overexpression of glutathione (GSH) has limited the anticancer effect of CDT. By preparing a GSH-depleting Cu(II)-half-salamo-based coordination polymer (CuCP), the anticancer efficacy of CDT can be enhanced.
DALTON TRANSACTIONS
(2022)
Article
Pharmacology & Pharmacy
Hao Liu, Yihan Kong, Zixu Liu, Xueting Guo, Bing Yang, Tian Yin, Haibing He, Jingxin Gou, Yu Zhang, Xing Tang
Summary: This study used sphingomyelin-based PEGylated liposomes as carriers to enhance the water solubility of the copper ion complex Cu (DDC)(2). Pharmacokinetic studies showed that loading Cu (DDC)(2) into liposomes improved bioavailability. Furthermore, liposomal encapsulation enhanced the anticancer effect of Cu (DDC)(2), resulting in a significant tumor-inhibiting rate in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Qing-Hua Lan, Chu-Chu Du, Run-Jie Yu, Jiaoyuan Zhai, Yannan Shi, Longfa Kou, Jian Xiao, Cui-Tao Lu, Ying-Zheng Zhao, Qing Yao
Summary: The study investigated the use of Tf-DSF/CuS nanocomplex for glioma therapy, demonstrating high cytotoxic effect in vitro and effective tumor growth suppression in vivo. The UTMD technique facilitated selective accumulation of the nanocomplex in the tumor, contributing to the successful treatment outcome.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Cell Biology
Marina Katsman, Aviva Azriel, Guy Horev, Yitzhak Reizel, Ben-Zion Levi
Summary: The study reveals the crucial role of N-VEGF as an autoregulatory arm of VEGF-A in angiogenesis and cell survival under hypoxic conditions.
Article
Chemistry, Medicinal
Iftekhar Hassan, Hossam Ebaid, Ibrahim M. Alhazza, Jameel Al-Tamimi, Ahmed M. Rady
Summary: The present study investigated the potential of combining the anticancer drug 5-FU with copper and its chelating agent, disulfiram, in treating hepatocellular carcinoma in rats. The combination treatment showed significant improvement in most parameters, improving histological details and triggering apoptosis in cancer cells to a remarkable extent. Manipulating copper levels greatly enhances the antineoplastic activity of 5-FU and sensitizes cancer cells to the increased efficacy of the drug.
Article
Biochemistry & Molecular Biology
Xin-Yu Fan, Jing-Yu Yang, Ying-Xu Dong, Ying Hou, Shuai Liu, Chun-Fu Wu
Article
Pharmacology & Pharmacy
Zhang Zhen, Yang Jingyu, Liu Chen, Xie Jun, Qiu Shi, Yang Xue, Wu Chunfu
PHARMACOLOGICAL RESEARCH
(2019)
Article
Cell Biology
Xue C. Yao, Xue Xue, Hao T. Zhang, Ming M. Zhu, Xiao W. Yang, Chun F. Wu, Jing Y. Yang
Article
Cell Biology
Yuhong Sun, Xuefei Bao, Yong Ren, Lina Jia, Shenglan Zou, Jian Han, Mengyue Zhao, Mei Han, Hong Li, Qixiang Hua, Yi Fang, Jingyu Yang, Chunfu Wu, Guoliang Chen, Lihui Wang
CELL DEATH & DISEASE
(2019)
Article
Neurosciences
Lei Zhu, Zhen Zhang, Xiao-jie Hou, Yong-feng Wang, Jing-yu Yang, Chun-fu Wu
Article
Cell Biology
Pengwei Wang, Ying Hou, Wen Zhang, Haotian Zhang, Xiaohang Che, Yongfeng Gao, Yinglu Liu, Depeng Yang, Jingmin Wang, Rongwu Xiang, Mingyi Zhao, Jingyu Yang
Article
Immunology
Ying Hou, Depeng Yang, Rongwu Xiang, Huiyang Wang, Xianshi Wang, Haotian Zhang, Pengwei Wang, Zhen Zhang, Xiaohang Che, Yinglu Liu, Yongfeng Gao, Xiangnan Yu, Xiaoyun Gao, Wen Zhang, Jingyu Yang, Chunfu Wu
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Plant Sciences
Kuo Zhang, Huili Weng, Jingyu Yang, Chunfu Wu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Plant Sciences
Kuo Zhang, Zhiqian Wang, Xing Pan, Jingyu Yang, Chunfu Wu
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Immunology
Xiaoxia Ye, Mingming Zhu, Xiaohang Che, Huiyang Wang, Xing-Jie Liang, Chunfu Wu, Xue Xue, Jingyu Yang
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Biochemistry & Molecular Biology
Linlin Yuan, Shibo Sun, Xiaohan Pan, Liqin Zheng, Yuting Li, Jingyu Yang, Chunfu Wu
NEUROCHEMISTRY INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Kuo Zhang, Fan Wang, Yang Zhao, Meiyao He, Yuanchao Luo, Yue Cheng, Jing Luo, Zhimei Li, Jingyu Yang
NEUROCHEMISTRY INTERNATIONAL
(2020)
Article
Neurosciences
Yinglu Liu, Chunfu Wu, Zongjuan Hou, Xiaoxiao Fu, Linlin Yuan, Shibo Sun, Haotian Zhang, Depeng Yang, Xuechun Yao, Jingyu Yang
Article
Cell Biology
Fangyang Wang, Ying Yang, Gabriel Boudagh, Eeva-Liisa Eskelinen, Daniel J. Klionsky, Sami N. Malek
Summary: The discovery of mutations in V-ATPase subunits and regulators in follicular lymphoma highlights the role of autophagy, amino acid, and nutrient-sensing pathways in the disease's pathogenesis. Novel mutations in the ER-resident chaperone VMA21 lead to mislocalization of VMA21 and impairment in V-ATPase activity, resulting in amino acid depletion and compensatory autophagy activation.
Article
Geriatrics & Gerontology
Xiao-Meng Wang, Ying Peng, Zhi-Wei Liu, Shuo-Ying Zhang, Jing-Yu Yang, Chun-Fu Wu, Xiao-Bo Li
INTERNATIONAL JOURNAL OF GERONTOLOGY
(2019)
Review
Oncology
Xinru Zhou, Yin Jia, Chuanbin Mao, Shanrong Liu
Summary: Small extracellular vesicles (sEVs), such as exosomes, have emerged as crucial targets for liquid biopsy and promising drug delivery vehicles in tumor progression. They can serve as biomarkers for tumor diagnosis and as drug carriers for cancer treatment.
Article
Oncology
Ruochan Chen, Ju Zhu, Xiao Zhong, Jie Li, Rui Kang, Daolin Tang
Summary: The interplay between autophagy and apoptosis plays a crucial role in tumorigenesis and cancer therapy, with HMGB1 serving as a key regulator in these processes.
Article
Oncology
Zongfu Pan, Xixuan Lu, Tong Xu, Jinming Chen, Lisha Bao, Ying Li, Yingying Gong, Yulu Che, Xiaozhou Zou, Zhuo Tan, Ping Huang, Minghua Ge
Summary: This study uncovered the emerging role of HN1 in promoting dedifferentiation of anaplastic thyroid cancer (ATC) cells. HN1 negatively regulated the thyroid differentiation markers and had an inhibitory effect on the transcriptional activation of CTCF, thereby influencing the chromatin accessibility of thyroid differentiation genes.
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Oncology
Katsuya Nagaoka, Xuewei Bai, Dan Liu, Kevin Cao, Joud Mulla, Chengcheng Ji, Hongze Chen, Muhammad Azhar Nisar, Amalia Bay, William Mueller, Grace Hildebrand, Jin-Song Gao, Shaolei Lu, Hiroko Setoyama, Yasuhito Tanaka, Jack R. Wands, Chiung-Kuei Huang
Summary: This study found that serum 2-OG levels in cholangiocarcinoma patients are associated with the effectiveness of chemotherapy. Patients with progressive disease showed significantly higher levels of serum 2-OG compared to stable disease and partial response patients. The study also revealed that overexpression of ASPH mimics the effects of 2-OG, and knockdown of ASPH improves chemotherapy. Targeting ASPH enhances the effects of chemotherapy by modulating ATM and ATR, two key regulators of DDRs.