期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 33, 期 8, 页码 1099-1104出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-016-0738-9
关键词
TDRD1; Piwi-interacting RNA; Polymorphism; Spermatogenesis impairment; Nonobstructive azoospermia
资金
- Shanghai Municipal Commission of Health and Family Planning [2013GY08]
- Shanghai Hospital Development Center [SHDC12014236]
- National High-Tech Research and Development Program (863) of China [2015AA020404]
To this end, five single-nucleotide polymorphisms (SNPs) in the ASZ1, PIWIL1, TDRD1, and TDRD9 genes were genotyped by TaqMan allelic discrimination assays in 342 cases of nonobstructive azoospermia (NOA) and 493 controls. The SNP rs77559927 in TDRD1 was associated with a reduced risk of spermatogenic impairment. The genotypes TC and TC + CC showed odds ratios and 95 % confidence intervals of 0.73 (0.55-0.98, P = 0.034) and 0.73 (0.56-0.97, P = 0.030), respectively, in patients with NOA compared with those in the controls. Thus, our results provided the first epidemiological evidence supporting the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in determining the risk of spermatogenic impairment in a Han Chinese population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据