Article
Biochemistry & Molecular Biology
Yizi Zhu, Mingzhu Chen, Yubo Zhang, Mei Han
Summary: This study found that stemazole can enhance the survival rate and clone formation of oligodendrocyte precursor cells (OPCs) and decrease cell apoptosis. In addition, in vivo experiments showed that stemazole promotes the recovery of motor dysfunction and repair of myelin sheaths. These findings suggest that stemazole may be a potential therapeutic agent for demyelinating diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Marisa A. Jeffries, Lauren E. McLane, Luipa Khandker, Marie L. Mather, Angelina V. Evangelou, Divyangi Kantak, Jennifer N. Bourne, Wendy B. Macklin, Teresa L. Wood
Summary: This study investigated the role of mTOR signaling in oligodendrocyte lineage during remyelination. The results showed that mTOR is required for metabolic function in cuprizone-demyelinated adult brain, influencing myelin production efficiency and myelin thickness during the repair process. Loss of mTOR in OPCs did not affect remyelination efficiency after other types of lesions, suggesting a specific function in cuprizone-induced demyelination.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Tess Dierckx, Sam Vanherle, Mansour Haidar, Elien Grajchen, Fleur Mingneau, Pascal Gervois, Esther Wolfs, Dany Bylemans, Arnout Voet, Tien Nguyen, Ibrahim Hamad, Markus Kleinewietfeld, Jeroen F. J. Bogie, Jerome J. A. Hendriks
Summary: This study reveals the reasons for the failure of remyelination, including the overly inflammatory microenvironment and the intrinsic inability of oligodendrocyte precursor cells to differentiate. The study also shows that phloretin can significantly promote remyelination by acting on the nuclear receptor peroxisome proliferator-activated receptor gamma to promote the maturation of oligodendrocyte precursor cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Shi-hao Cui, Na Suo, Ying Yang, Xuan Wu, Shi-meng Guo, Xin Xie
Summary: Oligodendrocytes (OLs), glial cells in the central nervous system, are responsible for forming myelin. It has been found that compounds U73122 and U73343 promote the differentiation of OLs and myelin regeneration by regulating the cholesterol biosynthesis pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Plant Sciences
Li Liu, Manjing Li, Qingwu Liu, Lina Yang, Lisong Sun, Yuxuan Guo, Yujie Li, Ying Chen, Xiaoxin Zhu, Qi Li
Summary: This study found that ginsenoside Rg1 (Rg1) promotes differentiation of oligodendrocyte precursor cells (OPCs) and myelin regeneration, showing promising therapeutic significance for functional recovery in neurodegenerative diseases such as multiple sclerosis.
Review
Cell Biology
Federica Cherchi, Anna Maria Pugliese, Elisabetta Coppi
Summary: Oligodendrocyte-formed myelin sheaths facilitate fast synaptic transmission in the brain, but their degeneration can lead to demyelinating diseases. Remyelination relies on the differentiation of oligodendrocyte progenitor cells into mature oligodendrocytes, with the neuromodulator adenosine and its receptors playing crucial roles in this process. The review highlights the potential therapeutic targets in demyelinating pathologies like multiple sclerosis by targeting adenosine receptor ligands.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Vito Antonio Baldassarro, Maura Cescatti, Maria Luisa Rocco, Luigi Aloe, Luca Lorenzini, Luciana Giardino, Laura Calza
Summary: This study revealed the impact of nerve growth factor (NGF) on the survival, differentiation, and maturation of astrocytes and the cells responsible for myelin formation, turnover, and repair in the central nervous system (CNS), as well as its protective role in OPCs under pathological conditions.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Mari Paz Serrano-Regal, Laura Bayon-Cordero, Juan Carlos Chara Ventura, Blanca Ochoa-Bueno, Vanja Tepavcevic, Carlos Matute, Maria Victoria Sanchez-Gomez
Summary: The GABA(B)R agonist baclofen has the potential to enhance oligodendrocyte progenitor cell differentiation and remyelination, suggesting it as a potential therapeutic strategy to stimulate remyelination in patients with multiple sclerosis (MS).
Review
Neurosciences
Morgan W. Psenicka, Brandon C. Smith, Rachel A. Tinkey, Jessica L. Williams
Summary: Neurodegenerative diseases often involve inflammation, and multiple sclerosis (MS) is a complex interplay between inflammation and neurodegeneration. Oligodendrocyte precursor cells (OPCs) play an active role in promoting neuroinflammation and neurodegeneration in MS, in addition to being a target of autoimmune pathology.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Henrique Rocha Mendonca, Camila Oliveira Goulart Villas Boas, Luiza dos Santos Heringer, Julia Teixeira Oliveira, Ana Maria Blanco Martinez
Summary: By conditionally deleting the pten gene in retinal ganglion cells and injecting zymosan plus cAMP, the study demonstrated an increase in oligodendrocyte staining and myelination in the regenerating optic nerve. This treatment also stimulated OPC proliferation and differentiation, leading to the myelination of regenerating CNS axons.
BRAIN RESEARCH BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Tania Aguado, Alba Huerga-Gomez, Anibal Sanchez-de La Torre, Eva Resel, Juan Carlos Chara, Carlos Matute, Susana Mato, Ismael Galve-Roperh, Manuel Guzman, Javier Palazuelos
Summary: Research shows that administration of THC from the hemp plant can enhance oligodendrocyte regeneration, white matter remyelination, and motor function recovery. THC also promotes axonal remyelination by inducing oligodendrocyte precursor differentiation through CB1 cannabinoid receptor activation.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ulises Gomez-Pinedo, Jordi A. Matias-Guiu, Maria Soledad Benito-Martin, Lidia Moreno-Jimenez, Inmaculada Sanclemente-Alaman, Belen Selma-Calvo, Sara Perez-Suarez, Francisco Sancho-Bielsa, Alejandro Canales-Aguirre, Juan Carlos Mateos-Diaz, Mercedes A. Hernandez-Sapiens, Edwin E. Reza-Zaldivar, Doddy Denise Ojeda-Hernandez, Lucia Vidorreta-Ballesteros, Paloma Montero-Escribano, Jorge Matias-Guiu
Summary: The study demonstrated that delivering HOG cells through the nasal route resulted in preferential migration to niches of OPCs in the CNS, potentially contributing to remyelination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Han Liu, Xueke Yang, Jing Yang, Yanpeng Yuan, Yanlin Wang, Rui Zhang, Huangui Xiong, Yuming Xu
Summary: IL-17 induces myelin damage through Kv1.3 activation, inhibiting proliferation and differentiation of Ol, impairing remyelination. Blocking Kv1.3 could be a potential therapeutic strategy for inflammatory CNS diseases by protecting OPC proliferation and differentiation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Meiling Luo, Ying Yin, Duanfang Li, Weiwei Tang, Yuan Liu, Lu Pan, Lehua Yu, Botao Tan
Summary: The bidirectional regulation of neuronal activity can effectively modulate the development of oligodendrocyte lineage cells and the remyelination process, ultimately affecting motor function recovery. Therefore, manipulation of neuronal activity is a promising avenue for the treatment of demyelination diseases in the central nervous system.
BRAIN RESEARCH BULLETIN
(2021)
Article
Plant Sciences
Jinfeng Yuan, Nuo Xu, Yanlin Tao, Xinyan Han, Liu Yang, Jinglei Liang, Haojieyin Jin, Xiaoxia Zhang, Hui Wu, Hailin Shi, Fei Huang, Xiaojun Wu
Summary: This study found that total astragalosides (TA) can effectively enhance the differentiation and maturation of oligodendrocyte progenitor cells (OPCs) and accelerate remyelination in a mouse model of multiple sclerosis (MS). TA achieves this through inhibition of the Wnt/8-catenin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Editorial Material
Cell Biology
Yifei Dong, V. Wee Yong
Article
Biochemistry & Molecular Biology
Julia Horjus, Tineke van Mourik-Banda, Marco A. P. Heerings, Marina Hakobjan, Ward De Witte, Dorothea J. Heersema, Anne J. Jansen, Eva M. M. Strijbis, Brigit A. de Jong, Astrid E. J. Slettenaar, Esther M. P. E. Zeinstra, Erwin L. J. Hoogervorst, Barbara Franke, Wiebe Kruijer, Peter J. Jongen, Leo J. Visser, Geert Poelmans
Summary: This study identified 12 rare genetic variants associated with multiple sclerosis through whole exome sequencing and co-segregation analysis, highlighting the involvement of various biological processes related to (de-/re-)myelination and auto-immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Alyssa A. Toorop, Laura Hogenboom, Karien Bloem, Merve Kocyigit, Nadine W. M. Commandeur, Anne Wijnants, Birgit Lissenberg-Witte, Eva M. M. Strijbis, Bernard M. J. Uitdehaag, Theo Rispens, Joep Killestein, Zoe L. E. van Kempen
Summary: This study aimed to evaluate the association between ocrelizumab drug concentration, antidrug antibodies (ADAs), and CD19 B-cell count, and to determine a cut-off ocrelizumab concentration for the start of B-cell repopulation. The results showed a negative correlation between ocrelizumab concentration and B-cell count, and measurement of ocrelizumab drug concentrations and ADAs can help personalize treatment and predict the start of B-cell repopulation.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Editorial Material
Cell Biology
Seyyed Mohyeddin Ziaee, Soheila Karimi-Abdolrezaee
NEURAL REGENERATION RESEARCH
(2023)
Article
Clinical Neurology
Marcus W. Koch, Pavle Repovic, Jop Mostert, James D. Bowen, Jacynthe Comtois, Eva Strijbis, Bernard Uitdehaag, Gary Cutter
Summary: This study investigates the short-term variation in T25FW and NHPT using patient-level original trial data and compares it with disability change at 12-month follow-up in people with PPMS. The traditional =20% change threshold for T25FW and NHPT represents a reasonable compromise between reducing false change events and achieving a large number of change events during follow-up.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Eloy Martinez-Heras, Elisabeth Solana, Francesc Vivo, Elisabet Lopez-Soley, Alberto Calvi, Salut Alba-Arbalat, Menno M. Schoonheim, Eva M. Strijbis, Hugo Vrenken, Frederik Barkhof, Maria A. Rocca, Massimo Filippi, Elisabetta Pagani, Sergiu Groppa, Vinzenz Fleischer, Robert A. Dineen, Barbara Bellenberg, Carsten Lukas, Deborah Pareto, Alex Rovira, Jaume Sastre-Garriga, Sara Collorone, Ferran Prados, Ahmed Toosy, Olga Ciccarelli, Albert Saiz, Yolanda Blanco, Sara Llufriu
Summary: This study analyzed brain diffusion-based connectivity in 823 MS patients and 221 healthy individuals using MRI and found that different clinical phenotypes of MS have distinct patterns of network changes and microstructural characteristics. Secondary progressive patients showed more widespread changes in connectivity compared to other groups.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Eva M. Strijbis, Eline Coerver, Jop Mostert, Zoe L. E. van Kempen, Joep Killestein, Jacynthe Comtois, Pavle Repovic, James D. Bowen, Gary Cutter, Marcus Koch
Summary: This study investigates the association between age and inflammatory disease activity in relapsing-remitting multiple sclerosis (RRMS) using patient-level data from randomized controlled trials (RCTs) of natalizumab treatment. The results show that older age is associated with lower prevalence and degree of focal inflammatory disease activity in treated and untreated RRMS patients. These findings provide important insights for the design of RCTs and the decision-making process of immunomodulatory treatment in RRMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Sara Xue, Brian M. Lozinski, Samira Ghorbani, Khanh Ta, Charlotte D. ' Mello, V. Wee Yong, Yifei Dong
Summary: Aging is a significant risk factor for neurodegenerative diseases like multiple sclerosis, as it causes dysfunction in microglia, the immune cells in the central nervous system. The gene Lgals3 (Gal3) is upregulated in aged microglia, and its excessive accumulation contributes to neuroinflammation and neurodegeneration in MS lesions. Understanding the mechanisms behind microglia dysfunction and Gal3 overexpression can provide new insights for promoting CNS repair and halting disease progression.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ka-Hoo Lam, Ioan Gabriel Bucur, Pim Van Oirschot, Frank De Graaf, Eva Strijbis, Bernard Uitdehaag, Tom Heskes, Joep Killestein, Vincent De Groot
Summary: This study investigated the use of remote smartphone-based 2-minute walking tests (s2MWTs) in assessing and detecting changes in ambulatory function in multiple sclerosis (MS) patients. The results showed that s2MWTs had large variability and were not sensitive to changes in clinical outcomes. However, individual-level curve fitting analysis was able to reduce variability and detect statistically reliable changes in ambulatory function in 45% of patients.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Review
Behavioral Sciences
Evan Forth, Benjamin Buehner, Ana Storer, Cassandra Sgarbossa, Roumen Milev, Arthi Chinna Meyyappan
Summary: Many psychiatric illnesses have a connection with the gut microbiome and the use of probiotics as supplements has shown efficacy in alleviating symptoms. This review evaluates the effects of adjuvant probiotic or synbiotic administration in combination with first-line treatments for psychiatric illnesses. The findings suggest that adjuvant probiotic treatment with selective serotonin reuptake inhibitors (SSRIs) is superior in improving symptoms of Major Depressive Disorder (MDD) and Generalized Anxiety Disorder (GAD) compared to SSRI treatment alone.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Editorial Material
Clinical Neurology
E. M. M. Strijbis, M. W. Koch, B. A. de Jong
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Mark H. J. Wessels, Zoe Y. G. J. Van Lierop, Samantha Noteboom, Eva M. M. Strijbis, Johannes A. Heijst, Zoe L. E. Van Kempen, Bastiaan Moraal, Frederik Barkhof, Bernard M. J. Uitdehaag, Menno M. Schoonheim, Joep Killestein, Charlotte E. Teunissen
Summary: This study aimed to evaluate the value of serum glial fibrillary acidic protein (sGFAP) as a biomarker for clinical disease progression and brain volume measurements in natalizumab-treated RRMS patients. The results showed that sGFAP levels correlated with MRI markers of neuroinflammation and neurodegeneration, suggesting its potential as a valuable biomarker for monitoring treatment response and disease progression in RRMS patients.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Marcus W. Koch, Ester Moral, Luis Brieva, Jop Mostert, Eva M. M. Strijbis, Jacynthe Comtois, Pavle Repovic, James D. Bowen, Jerry S. Wolinsky, Fred D. Lublin, Gary Cutter
Summary: This study investigated the time course of relapse recovery and its association with patient factors in people with relapsing-remitting MS. The findings showed that recovery from relapses can occur up to approximately 1 year after the event, and the severity of the relapse is the only factor associated with the speed of recovery.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Rozemarijn M. Mattiesing, Eline Kramer, Eva M. M. Strijbis, Iman Brouwer, Ronald A. van Schijndel, Giordano Gentile, Marco Battaglini, Nicola De Stefano, Bernard M. J. Uitdehaag, Frederik Barkhof, Hugo Vrenken, Menno M. Schoonheim
Summary: The degree of inflammation and neurodegeneration after treatment initiation in multiple sclerosis (MS) can predict disease progression. This study found that global atrophy and/or pseudo-atrophy as well as positive lesion activity in MRI results during the first and second years of treatment were related to an increased probability and faster conversion to clinically definite MS. Negative lesion activity in the first year and slower central atrophy in the second year were predictive of disability progression.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Zoe L. E. van Kempen, Koos P. J. van Dam, Jim B. D. Keijser, Eileen W. Stalman, Laura Y. L. Kummer, Eva M. M. Strijbis, Maurice Steenhuis, Anja ten Brinke, S. Marieke van Ham, Taco Kuijpers, Theo Rispens, Filip Eftimov, Luuk Wieske, Joep Killestein
Summary: Repeated SARS-CoV-2 vaccinations boost humoral immunity and induce long-term humoral responses in MS patients on fingolimod therapy.
MULTIPLE SCLEROSIS JOURNAL
(2023)