Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles

Targeting double-strand break indel byproducts with secondary guide RNAs improves Cas9 HDR-mediated genome editing efficiencies

(2022) Zsolt Bodai et al.   Nature Communications

Gene-drive suppression of mosquito populations in large cages as a bridge between lab and field

(2021) Andrew Hammond et al.   Nature Communications

Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline

(2021) Alexander J. Weitzel et al.   PLOS BIOLOGY

A transcomplementing gene drive provides a flexible platform for laboratory investigation and potential field deployment

(2020) Víctor López Del Amo et al.   Nature Communications

Genetic Biocontrol for Invasive Species

(2020) John L. Teem et al.   Frontiers in Bioengineering and Biotechnology

Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives

(2020) Víctor López Del Amo et al.   Cell Reports

Active Genetic Neutralizing Elements for Halting or Deleting Gene Drives

(2020) Xiang-Ru Shannon Xu et al.   MOLECULAR CELL

Rational selection of CRISPR/Cas9 guide RNAs for homology directed genome editing

(2020) Kristina J. Tatiossian et al.   MOLECULAR THERAPY

Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae

(2020) Rebeca Carballar-Lejarazú et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPResso2 provides accurate and rapid genome editing sequence analysis

(2019) Kendell Clement et al.   NATURE BIOTECHNOLOGY

Super-Mendelian inheritance mediated by CRISPR–Cas9 in the female mouse germline

(2019) Hannah A. Grunwald et al.   NATURE

Self-destructing mosquitoes and sterilized rodents: the promise of gene drives

(2019) Megan Scudellari   NATURE

Massively parallel profiling and predictive modeling of the outcomes of CRISPR/Cas9-mediated double-strand break repair

(2019) Wei Chen et al.   NUCLEIC ACIDS RESEARCH

Experimental population modification of the malaria vector mosquito, Anopheles stephensi

(2019) Thai Binh Pham et al.   PLoS Genetics

Reducing resistance allele formation in CRISPR gene drive

(2018) Jackson Champer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes

(2018) Kyros Kyrou et al.   NATURE BIOTECHNOLOGY

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs

(2018) Georg Oberhofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target-Specific Precision of CRISPR-Mediated Genome Editing

(2018) Anob M. Chakrabarti et al.   MOLECULAR CELL

Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations

(2017) Jackson Champer et al.   PLoS Genetics

Homology-Directed Recombination for Enhanced Engineering of Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   Molecular Therapy-Methods & Clinical Development

The dawn of active genetics

(2015) Valentino M. Gantz et al.   BIOESSAYS

A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

(2015) Andrew Hammond et al.   NATURE BIOTECHNOLOGY

Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquitoAnopheles stephensi

(2015) Valentino M. Gantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations

(2015) V. M. Gantz et al.   SCIENCE

Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila

(2014) F. Port et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Efficient Targeted Mutagenesis of Drosophila with the CRISPR/Cas9 System

(2014) Andrew R. Bassett et al.   Cell Reports