期刊
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
卷 15, 期 6, 页码 1283-1296出版社
SPRINGER
DOI: 10.1007/s12265-022-10275-4
关键词
A disintegrin and metalloprotease 17; Atherosclerosis; Inflammation; Vascular biology
资金
- Natural Science Foundation of Hunan Province [2020JJ4850, 2021JJ31026]
This article reviews the role of ADAM17 in atherosclerosis, explores its regulatory mechanisms, and discusses controversial points in disease development, aiming to provide rational management strategies for atherosclerosis.
Atherosclerosis is a chronic inflammatory disease that poses a huge economic burden due to its extremely poor prognosis. Therefore, it is necessary to explore potential mechanisms to improve the prevention and treatment of atherosclerosis. A disintegrin and metalloprotease 17 (ADAM17) is a cell membrane-bound protein that performs a range of functions through membrane protein shedding and intracellular signaling. ADAM17-mediated inflammation has been identified to be an important contributor to atherosclerosis; however, the specific relationship between its multiple regulatory roles and the pathogenesis of atherosclerosis remains unclear. Here, we reviewed the activation, function, and regulation of ADAM17, described in detail the role of ADAM17-mediated inflammatory damage in atherosclerosis, and discussed several controversial points. We hope that these insights into ADAM17 biology will lead to rational management of atherosclerosis.
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