Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis

Inactivation of EGLN3 hydroxylase facilitates Erk3 degradation via autophagy and impedes lung cancer growth

(2022) Ying Jin et al.   ONCOGENE

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner

(2021) Cheng Zhang et al.   Cell Death & Disease

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis

(2021) Trevor P. Fidler et al.   NATURE

Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

(2021) Hongxu Xian et al.   IMMUNITY

Pyroptosis in the Initiation and Progression of Atherosclerosis

(2021) Zhengtao Qian et al.   Frontiers in Pharmacology

VX-765 attenuates atherosclerosis in ApoE deficient mice by modulating VSMCs pyroptosis

(2020) Yiyi Li et al.   EXPERIMENTAL CELL RESEARCH

Inflammasome activation by NLRP1 and NLRC4 in patients with coronary stenosis

(2020) Maria Eduarda de Albuquerque Borborema et al.   IMMUNOBIOLOGY

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

(2020) Nathalia Moraes de Vasconcelos et al.   Cell Reports

Novel Role for Tranilast in Regulating NLRP3 Ubiquitination, Vascular Inflammation, and Atherosclerosis

(2020) Suwen Chen et al.   Journal of the American Heart Association

Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state

(2020) Daniela Cerezo-Wallis et al.   NATURE MEDICINE

Pre-symptomatic Caspase-1 inhibitor delays cognitive decline in a mouse model of Alzheimer disease and aging

(2020) Joseph Flores et al.   Nature Communications

Emerging views of mitophagy in immunity and autoimmune diseases

(2019) Ye Xu et al.   Autophagy

Novel Insights Into the NLRP3 Inflammasome in Atherosclerosis

(2019) Ying Jin et al.   Journal of the American Heart Association

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Macrophages in Atherosclerosis Regression

(2019) Tessa J. Barrett   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis

(2018) Trent D. Evans et al.   Autophagy

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol

(2018) Shiori Sekine et al.   BMC BIOLOGY

Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1β Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis

(2018) Gantsetseg Tumurkhuu et al.   Cell Metabolism

Macrophage-derived Neuropilin-2 exhibits novel tumor-promoting functions

(2018) Sohini Roy et al.   CANCER RESEARCH

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation

(2018) Zhenyu Zhong et al.   NATURE

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease

(2018) Eithne M. Maguire et al.   VASCULAR PHARMACOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

Catalytic-independent inhibition of cIAP1-mediated RIP1 ubiquitination by EGLN3

(2016) Jian Fu   CELLULAR SIGNALLING

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy

(2014) J. Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear

(2013) W. Pan et al.   JOURNAL OF NEUROSCIENCE

EGLN3 Inhibition of NF- B Is Mediated by Prolyl Hydroxylase-Independent Inhibition of I B Kinase   Ubiquitination

(2013) J. Fu et al.   MOLECULAR AND CELLULAR BIOLOGY

Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome

(2013) Takuma Misawa et al.   NATURE IMMUNOLOGY

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

(2013) Clinton S Robbins et al.   NATURE MEDICINE

Caspase-1 Deficiency Decreases Atherosclerosis in Apolipoprotein E-Null Mice

(2012) Jessica Gage et al.   CANADIAN JOURNAL OF CARDIOLOGY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

Manipulation of Host Cell Death Pathways during Microbial Infections

(2010) Mohamed Lamkanfi et al.   Cell Host & Microbe

Prolyl Hydroxylase EGLN3 Regulates Skeletal Myoblast Differentiation through an NF-κB-dependent Pathway

(2010) Jian Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe −/− Mice

(2008) Edward Thorp et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY