Role of the homologous MTase-RdRp interface of flavivirus intramolecular NS5 on duck tembusu virus

Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase

(2021) Eunhye Lee et al.   Nature Communications

Nuclear localization of duck Tembusu virus NS5 protein attenuates viral replication in vitro and NS5-NS2B3 interaction

(2021) Miao Zeng et al.   VETERINARY MICROBIOLOGY

A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase

(2020) Jiqin Wu et al.   PLoS Pathogens

Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses

(2020) Jieyu Yang et al.   NUCLEIC ACIDS RESEARCH

Genetically stable reporter virus, subgenomic replicon and packaging system of duck Tembusu virus based on a reverse genetics system

(2019) Yu He et al.   VIROLOGY

Structure of the yellow fever NS5 protein reveals conserved drug targets shared among flaviviruses

(2019) Anna Dubankova et al.   ANTIVIRAL RESEARCH

Binding of the Duck Tembusu Virus Protease to STING Is Mediated by NS2B and Is Crucial for STING Cleavage and for Impaired Induction of IFN-β

(2019) Zhen Wu et al.   JOURNAL OF IMMUNOLOGY

Establishment of reverse genetics system for duck Tembusu virus to study virulence and screen antiviral genes

(2018) Shun Chen et al.   ANTIVIRAL RESEARCH

Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication

(2018) Timur Rusanov et al.   Scientific Reports

An updated review of avian-origin Tembusu virus: a newly emerging avian Flavivirus

(2017) Wei Zhang et al.   JOURNAL OF GENERAL VIROLOGY

The structure of Zika virus NS5 reveals a conserved domain conformation

(2017) Boxiao Wang et al.   Nature Communications

Crystal structure of full-lengthZika virusNS5 protein reveals a conformation similar toJapanese encephalitis virusNS5

(2017) Anup K. Upadhyay et al.   Acta Crystallographica Section F-Structural Biology Communications

Identification of the critical linker residues conferring differences in the compactness of NS5 fromDengue virusserotype 4 and NS5 fromDengue virusserotypes 1–3

(2016) Malathy Sony Subramanian Manimekalai et al.   Acta Crystallographica Section D-Structural Biology

Identification and molecular characterization of a novel duck Tembusu virus isolate from Southwest China

(2015) Kesen Zhu et al.   ARCHIVES OF VIROLOGY

Flexibility of NS5 Methyltransferase-Polymerase Linker Region Is Essential for Dengue Virus Replication

(2015) Yongqian Zhao et al.   JOURNAL OF VIROLOGY

The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

(2015) Supanee Potisopon et al.   NUCLEIC ACIDS RESEARCH

A Crystal Structure of the Dengue Virus NS5 Protein Reveals a Novel Inter-domain Interface Essential for Protein Flexibility and Virus Replication

(2015) Yongqian Zhao et al.   PLoS Pathogens

Structural insight and flexible features of NS5 proteins from all four serotypes of Dengue virus in solution

(2015) Wuan Geok Saw et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation

(2014) Jiqin Wu et al.   JOURNAL OF VIROLOGY

The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication

(2014) Xiao-Dan Li et al.   PLoS Neglected Tropical Diseases

A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability andde NovoInitiation Activities

(2013) Siew Pheng Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface

(2013) Guoliang Lu et al.   PLoS Pathogens

Crystal Structure of a Novel Conformational State of the Flavivirus NS3 Protein: Implications for Polyprotein Processing and Viral Replication

(2009) R. Assenberg et al.   JOURNAL OF VIROLOGY