Urosepsis-targeted diagnostics and effective therapy

Urinary tract infections (UTIs) are characterized by a broad clinical presentation ranging from uncomplicated cystitis to septic shock. 9-31% of all septicemias have a urogenital focus and are referred to as urosepsis. Urosepsis often occurs in the context of health system-associated infections. Obstructive uropathy (e.g., urolithiasis, tumors, strictures) is a major risk factor. The severity and course of urosepsis depend not only on the pathogenicity of the pathogen but also on the type and extent of the individual immune response. Therapy is divided into causal (antimicrobial therapy and focal sanitation), supportive (hemodynamic and pulmonal stabilization), and adjunctive (glucocorticoid and insulin therapy) therapy and should be initiated without delay. Due to demographic change, a further increase in urosepsis is expected in the future, so every urologist should be familiar with targeted diagnostics and effective therapy.

Automated summary

Urinary tract infections (UTIs) can present with a wide range of clinical symptoms, from uncomplicated cystitis to septic shock. Urosepsis, a type of septicemia, often occurs in the context of infections related to the urogenital system. Obstructive uropathy is a major risk factor. The severity and course of urosepsis depend not only on the pathogen's virulence, but also on the individual's immune response. Treatment involves antimicrobial therapy, focal sanitation, supportive therapy, and adjunctive therapy. The future is expected to see a further increase in urosepsis due to demographic change.