The current toolbox for APOBEC drug discovery

The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present

(2021) Keiya Uriu et al.   Viruses-Basel

Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor

(2021) Fareeda M. Barzak et al.   Viruses-Basel

APOBECs and Herpesviruses

(2021) Adam Z. Cheng et al.   Viruses-Basel

Structural basis of substrate specificity in human cytidine deaminase family APOBEC3s

(2021) Shurong Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

(2020) Andrew V. Anzalone et al.   NATURE BIOTECHNOLOGY

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

(2020) Emily K. Law et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The interesting relationship between APOBEC3 deoxycytidine deaminases and cancer: a long road ahead

(2020) Milaid Granadillo Rodríguez et al.   Open Biology

A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes

(2019) A. St. Martin et al.   Scientific Reports

The APOBEC3 genes and their role in cancer: insights from human papillomavirus

(2019) Nicola J Smith et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Structural Investigations on the Interactions between Cytidine Deaminase Human APOBEC3G and DNA

(2019) Xiaoxuan Yan et al.   Chemistry-An Asian Journal

The DNA deaminase APOBEC3B interacts with the cell cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1

(2019) Jennifer M. McCann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The spectrum of APOBEC3 activity: From anti-viral agents to anti-cancer opportunities

(2019) Abby M. Green et al.   DNA REPAIR

Thermophoresis of biological and biocompatible compounds in aqueous solution

(2019) D Niether et al.   JOURNAL OF PHYSICS-CONDENSED MATTER

Differential Inhibition of APOBEC3 DNA‐Mutator Isozymes by Fluoro‐ and Non‐Fluoro‐Substituted 2′‐Deoxyzebularine Embedded in Single‐Stranded DNA

(2019) Maksim V. Kvach et al.   CHEMBIOCHEM

Structural basis of antagonism of human APOBEC3F by HIV-1 Vif

(2019) Yingxia Hu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution

(2018) S Venkatesan et al.   ANNALS OF ONCOLOGY

Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like family genes activation and regulation during tumorigenesis

(2018) Jianlong Gao et al.   CANCER SCIENCE

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces

(2018) Daniel J. Salamango et al.   JOURNAL OF MOLECULAR BIOLOGY

Thermophoresis for characterizing biomolecular interaction

(2018) Mufarreh Asmari et al.   METHODS

The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism

(2018) Nadine M. Shaban et al.   MOLECULAR CELL

Current NMR Techniques for Structure-Based Drug Discovery

(2018) Toshihiko Sugiki et al.   MOLECULES

A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC–Cas9 or cleavage by Cas9 in living cells

(2018) Amber St. Martin et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA

(2018) Atanu Maiti et al.   Nature Communications

Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation

(2018) Ling Ma et al.   Scientific Reports

DRONE: Direct Tracking of DNA Cytidine Deamination and Other DNA Modifying Activities

(2018) Tomoaki Sasaki et al.   ANALYTICAL CHEMISTRY

Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues

(2018) Maksim V. Kvach et al.   BIOCHEMISTRY

Structural Analysis of the Active Site and DNA Binding of Human Cytidine Deaminase APOBEC3B

(2018) Shurong Hou et al.   Journal of Chemical Theory and Computation

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

(2018) Jay B. Fell et al.   ACS Medicinal Chemistry Letters

Epstein–Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity

(2018) Adam Z. Cheng et al.   Nature Microbiology

Solution NMR Spectroscopy in Target-Based Drug Discovery

(2017) et al.   MOLECULES

Enzyme cycling contributes to efficient induction of genome mutagenesis by the cytidine deaminase APOBEC3B

(2017) Madison B. Adolph et al.   NUCLEIC ACIDS RESEARCH

Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization

(2017) Madison B. Adolph et al.   NUCLEIC ACIDS RESEARCH

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate

(2017) Stefan Harjes et al.   NUCLEIC ACIDS RESEARCH

Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression

(2017) Cody Warren et al.   Viruses-Basel

Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity

(2017) Takahide Kouno et al.   Nature Communications

APOBEC3B, a molecular driver of mutagenesis in human cancers

(2017) Jun Zou et al.   Cell and Bioscience

Nuclear Magnetic Resonance Structure of the APOBEC3B Catalytic Domain: Structural Basis for Substrate Binding and DNA Deaminase Activity

(2016) In-Ja L. Byeon et al.   BIOCHEMISTRY

Functions and Malfunctions of Mammalian DNA-Cytosine Deaminases

(2016) Sachini U. Siriwardena et al.   CHEMICAL REVIEWS

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

(2016) Alexis C. Komor et al.   NATURE

Twenty years on: the impact of fragments on drug discovery

(2016) Daniel A. Erlanson et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Editing by APOBECs: A Genomic Preserver and Transformer

(2016) Binyamin A. Knisbacher et al.   TRENDS IN GENETICS

Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B

(2016) Ke Shi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

(2016) Krista A. Delviks-Frankenberry et al.   PLoS Pathogens

The DNA cytosine deaminase APOBEC3B promotes tamoxifen resistance in ER-positive breast cancer

(2016) E. K. Law et al.   Science Advances

DNA cytosine and methylcytosine deamination by APOBEC3B: enhancing methylcytosine deamination by engineering APOBEC3B

(2015) Y. Fu et al.   BIOCHEMICAL JOURNAL

Natural Polymorphisms and Oligomerization of Human APOBEC3H Contribute to Single-stranded DNA Scanning Ability

(2015) Yuqing Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain

(2015) Ke Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

(2015) Takahide Kouno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates

(2015) Bogdan Polevoda et al.   NUCLEIC ACIDS RESEARCH

Catalytic Pocket Inaccessibility of Activation-Induced Cytidine Deaminase Is a Safeguard against Excessive Mutagenic Activity

(2015) Justin J. King et al.   STRUCTURE

The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization

(2015) Markus-Frederik Bohn et al.   STRUCTURE

APOBECs and virus restriction

(2015) Reuben S. Harris et al.   VIROLOGY

Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

(2015) Takahide Kouno et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Reaction Mechanism of Zinc-Dependent Cytosine Deaminase from Escherichia coli: A Quantum-Chemical Study

(2014) Bianca Manta et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Lack of Association between Intact/Deletion Polymorphisms of the APOBEC3B Gene and HIV-1 Risk

(2014) Mayumi Imahashi et al.   PLoS One

A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity

(2014) Eric C. Logue et al.   PLoS One

Different Mutagenic Potential of HIV-1 Restriction Factors APOBEC3G and APOBEC3F Is Determined by Distinct Single-Stranded DNA Scanning Mechanisms

(2014) Anjuman Ara et al.   PLoS Pathogens

Impact of H216 on the DNA Binding and Catalytic Activities of the HIV Restriction Factor APOBEC3G

(2013) S. Harjes et al.   JOURNAL OF VIROLOGY

Evidence for APOBEC3B mutagenesis in multiple human cancers

(2013) Michael B Burns et al.   NATURE GENETICS

An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers

(2013) Steven A Roberts et al.   NATURE GENETICS

Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F

(2013) Karen K. Siu et al.   Nature Communications

NMR structure of human restriction factor APOBEC3A reveals substrate binding and enzyme specificity

(2013) In-Ja L. Byeon et al.   Nature Communications

Label-Free Microscale Thermophoresis Discriminates Sites and Affinity of Protein-Ligand Binding

(2012) Susanne A. I. Seidel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mutational Processes Molding the Genomes of 21 Breast Cancers

(2012) Serena Nik-Zainal et al.   CELL

Small-Molecule APOBEC3G DNA Cytosine Deaminase Inhibitors Based on a 4-Amino-1,2,4-triazole-3-thiol Scaffold

(2012) Margaret E. Olson et al.   ChemMedChem

Biochemical Analysis of Hypermutation by the Deoxycytidine Deaminase APOBEC3A

(2012) Robin P. Love et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AIDing the immune system—DIAbolic in cancer

(2012) Kerstin-Maike Schmitz et al.   SEMINARS IN IMMUNOLOGY

Base Damage within Single-Strand DNA Underlies In Vivo Hypermutability Induced by a Ubiquitous Environmental Agent

(2012) Kin Chan et al.   PLoS Genetics

First-In-Class Small Molecule Inhibitors of the Single-Strand DNA Cytosine Deaminase APOBEC3G

(2011) Ming Li et al.   ACS Chemical Biology

Three-Dimensional Structure and Catalytic Mechanism of Cytosine Deaminase

(2011) Richard S. Hall et al.   BIOCHEMISTRY

Human and Rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H Demonstrate a Conserved Capacity To Restrict Vif-Deficient HIV-1

(2011) J. F. Hultquist et al.   JOURNAL OF VIROLOGY

The Role of Amino-Terminal Sequences in Cellular Localization and Antiviral Activity of APOBEC3B

(2011) V. Pak et al.   JOURNAL OF VIROLOGY

Determinants of sequence-specificity within human AID and APOBEC3G

(2010) Michael A. Carpenter et al.   DNA REPAIR

Small Molecular Compounds Inhibit HIV-1 Replication through Specifically Stabilizing APOBEC3G

(2010) Shan Cen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human APOBEC3G-Mediated Editing Can Promote HIV-1 Sequence Diversification and Accelerate Adaptation to Selective Pressure

(2010) E.-Y. Kim et al.   JOURNAL OF VIROLOGY

Protein-binding assays in biological liquids using microscale thermophoresis

(2010) Christoph J. Wienken et al.   Nature Communications

Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G

(2009) Ayako Furukawa et al.   EMBO JOURNAL

An Extended Structure of the APOBEC3G Catalytic Domain Suggests a Unique Holoenzyme Model

(2009) Elena Harjes et al.   JOURNAL OF MOLECULAR BIOLOGY

Likely Role of APOBEC3G-Mediated G-to-A Mutations in HIV-1 Evolution and Drug Resistance

(2009) Patric Jern et al.   PLoS Pathogens

Two Regions within the Amino-Terminal Half of APOBEC3G Cooperate To Determine Cytoplasmic Localization

(2008) M. D. Stenglein et al.   JOURNAL OF VIROLOGY

Polymorphisms and Splice Variants Influence the Antiretroviral Activity of Human APOBEC3H

(2008) A. Harari et al.   JOURNAL OF VIROLOGY

Guidelines for Naming Nonprimate APOBEC3 Genes and Proteins

(2008) R. S. LaRue et al.   JOURNAL OF VIROLOGY

The DNA Deaminase Activity of Human APOBEC3G Is Required for Ty1, MusD, and Human Immunodeficiency Virus Type 1 Restriction

(2008) A. J. Schumacher et al.   JOURNAL OF VIROLOGY

Structure of the DNA deaminase domain of the HIV-1 restriction factor APOBEC3G

(2008) Kuan-Ming Chen et al.   NATURE

Enhancing immunity to HIV through APOBEC

(2008) Reuben S Harris   NATURE BIOTECHNOLOGY

Cytidine deamination induced HIV-1 drug resistance

(2008) L. C. F. Mulder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Vif, APOBEC, and Intrinsic Immunity

(2008) Ritu Goila-Gaur et al.   Retrovirology

The AID/APOBEC family of nucleic acid mutators

(2008) Silvestro G Conticello   GENOME BIOLOGY