Memory B cell diversity: insights for optimized vaccine design

Germinal Centers

(2022) Gabriel D. Victora et al.   Annual Review of Immunology

Development of Tbet- and CD11c-expressing B cells in a viral infection requires T follicular helper cells outside of germinal centers

(2022) Wenzhi Song et al.   IMMUNITY

Lung-resident memory B cells established after pulmonary influenza infection display distinct transcriptional and phenotypic profiles

(2022) Hyon-Xhi Tan et al.   Science Immunology

Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans

(2021) Henry J. Sutton et al.   Cell Reports

Profiling B cell immunodominance after SARS-CoV-2 infection reveals antibody evolution to non-neutralizing viral targets

(2021) Haley L. Dugan et al.   IMMUNITY

Soluble FAS Ligand Enhances Suboptimal CD40L/IL-21–Mediated Human Memory B Cell Differentiation into Antibody-Secreting Cells

(2021) Saskia D. van Asten et al.   JOURNAL OF IMMUNOLOGY

SARS-CoV-2 infection induces long-lived bone marrow plasma cells in humans

(2021) Jackson S. Turner et al.   NATURE

SARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses

(2021) Jackson S. Turner et al.   NATURE

Immune imprinting and SARS-CoV-2 vaccine design

(2021) Adam K. Wheatley et al.   TRENDS IN IMMUNOLOGY

B Cell Responses against Influenza Viruses: Short-Lived Humoral Immunity against a Life-Long Threat

(2021) Jenna J. Guthmiller et al.   Viruses-Basel

Pre-existing humoral immunity to human common cold coronaviruses negatively impacts the protective SARS-CoV-2 antibody response

(2021) Chun-Yang Lin et al.   Cell Host & Microbe

Surface phenotypes of naive and memory B cells in mouse and human tissues

(2021) Nadine M. Weisel et al.   NATURE IMMUNOLOGY

Temporal dynamics of persistent germinal centers and memory B cell differentiation following respiratory virus infection

(2021) William T. Yewdell et al.   Cell Reports

Resident Memory B Cells

(2020) S. Rameeza Allie et al.   VIRAL IMMUNOLOGY

CD11c+ B Cells Are Mainly Memory Cells, Precursors of Antibody Secreting Cells in Healthy Donors

(2020) Marie-Laure Golinski et al.   Frontiers in Immunology

Malaria exposure drives both cognate and bystander human B cells to adopt an atypical phenotype

(2020) Racheal Aye et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor T-bet Resolves Memory B Cell Subsets with Distinct Tissue Distributions and Antibody Specificities in Mice and Humans

(2020) John L. Johnson et al.   IMMUNITY

Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

(2020) René Riedel et al.   Nature Communications

CD95 Structure, Aggregation and Cell Signaling

(2020) Nicolas Levoin et al.   Frontiers in Cell and Developmental Biology

An Integrated Multi-omic Single-Cell Atlas of Human B Cell Identity

(2020) David R. Glass et al.   IMMUNITY

Imprinting, immunodominance, and other impediments to generating broad influenza immunity

(2020) Matthew Knight et al.   IMMUNOLOGICAL REVIEWS

Original antigenic sin priming of influenza virus hemagglutinin stalk antibodies

(2020) Claudia P. Arevalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of atypical memory B cells is a prominent feature of COVID-19

(2020) Barbara Oliviero et al.   Cellular & Molecular Immunology

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity

(2020) Ellen Shrock et al.   SCIENCE

Activated Human Memory B Lymphocytes Use CR4 (CD11c/CD18) for Adhesion, Migration, and Proliferation

(2020) Zsuzsa Nagy-Baló et al.   Frontiers in Immunology

Skewed CD39/CD73/adenosine pathway contributes to B-cell hyperactivation and disease progression in patients with chronic hepatitis B

(2020) Shuang-Nan Zhou et al.   Gastroenterology Report

Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma

(2020) Raud Razzaghi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Remembering seasonal coronaviruses

(2020) Jenna J. Guthmiller et al.   SCIENCE

Parallel analysis of tri-molecular biosynthesis with cell identity and function in single cells

(2019) Samuel C. Kimmey et al.   Nature Communications

Outflanking immunodominance to target subdominant broadly neutralizing epitopes

(2019) Davide Angeletti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription Factor T-bet in B Cells Modulates Germinal Center Polarization and Antibody Affinity Maturation in Response to Malaria

(2019) Ann Ly et al.   Cell Reports

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting

(2019) Luka Mesin et al.   CELL

Understanding and Manipulating Viral Immunity: Antibody Immunodominance Enters Center Stage

(2018) Davide Angeletti et al.   TRENDS IN IMMUNOLOGY

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

Natural Killer Cell Recruitment to the Lung During Influenza A Virus Infection Is Dependent on CXCR3, CCR5, and Virus Exposure Dose

(2018) Lindsey E. Carlin et al.   Frontiers in Immunology

The influenza virus hemagglutinin head evolves faster than the stalk domain

(2018) Ericka Kirkpatrick et al.   Scientific Reports

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

(2018) Scott A. Jenks et al.   IMMUNITY

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

CXCR3 Signaling Is Required for Restricted Homing of Parenteral Tuberculosis Vaccine–Induced T Cells to Both the Lung Parenchyma and Airway

(2017) Mangalakumari Jeyanathan et al.   JOURNAL OF IMMUNOLOGY

CD95/Fas, Non-Apoptotic Signaling Pathways, and Kinases

(2017) Matthieu Le Gallo et al.   Frontiers in Immunology

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

(2016) Florian J. Weisel et al.   IMMUNITY

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

(2016) Katelyn M. Gostic et al.   SCIENCE

Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion

(2016) Liang Gao et al.   eLife

Focused antibody response to influenza linked to antigenic drift

(2015) Kuan-Ying A. Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Immune history profoundly affects broadly protective B cell responses to influenza

(2015) Sarah F. Andrews et al.   Science Translational Medicine

Malaria-associated atypical memory B cells exhibit markedly reduced B cell receptor signaling and effector function

(2015) Silvia Portugal et al.   eLife

Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD

(2014) A. Khoder et al.   BLOOD

Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals

(2014) Lela Kardava et al.   JOURNAL OF CLINICAL INVESTIGATION

CD80 and PD-L2 define functionally distinct memory B cell subsets that are independent of antibody isotype

(2014) Griselda V Zuccarino-Catania et al.   NATURE IMMUNOLOGY

Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins

(2013) N. S. Heaton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Fas/CD95 Receptor Regulates the Death of Autoreactive B Cells and the Selection of Antigen-Specific B Cells

(2012) Gabor Koncz et al.   Frontiers in Immunology

Clonal B cells in patients with hepatitis C virus-associated mixed cryoglobulinemia contain an expanded anergic CD21low B-cell subset

(2011) E. D. Charles et al.   BLOOD

Pivotal Advance: CD45RB glycosylation is specifically regulated during human peripheral B cell differentiation

(2011) S. Koethe et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones

(2010) I. Isnardi et al.   BLOOD

Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells

(2010) Y. Iwata et al.   BLOOD

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

(2008) Susan Moir et al.   JOURNAL OF EXPERIMENTAL MEDICINE