期刊
CANCER INVESTIGATION
卷 34, 期 1, 页码 1-11出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/07357907.2015.1081921
关键词
Exosome; Prostate cancer; Proteome; Biomarker; Health disparity; Early detection
类别
资金
- Center for Health Disparities AMP
- Molecular Medicine
Prostate cancer (PCa) remains the most frequently diagnosed male malignancy in Western countries and the second most common cause of male cancer death in the United States. The relatively elevated PCa incidence and mortality among African American men makes this cancer type a challenging health disparity disease. To increase the chance for successful trea tment, earlier detection and prediction of tumor aggress iveness will be important and need to be resolved. This study demonstrates that small membrane-bound vesicles shed from the tumor called exosomes contain ethnically and tumor-specific biomarkers, and could be exploited for their diagnostic and therapeutic potential.
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