期刊
SMALL
卷 18, 期 26, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202201803
关键词
biomimetic peptides; black phosphorus; cancer nanotechnology; delivery; synergistic therapy
类别
资金
- National Natural Science Foundation of China [32071342, 21875092, 31922042]
- National Key Research and Development Program of China [2019YFA0112000]
- Guangdong Special Support Program [2019TQ05Y209]
- Natural Science Foundation of Guangdong Province [2021A1515010431]
- Science, Technology & Innovation Commission of Shenzhen Municipality [2021A18.GXWD20201231165807008]
- Fundamental Research Funds for the Central Universities [2021-RC310-005, 2020-RC320-002]
In this study, surface modification strategies were used to improve the inherent instability of bare black phosphorus nanosheets (BP NSs). A biomimetic peptide with azide groups was synthesized for surface modification to increase the stability of BP NSs. Additionally, a coordination network was constructed for magnetic resonance imaging and inducing intracellular escape. The fabricated nanoplatform exhibited enhanced antitumor abilities through synergistic chemo/photothermal effects in vitro and in vivo.
As a promising 2D nanocarrier, the biggest challenge of bare black phosphorus nanosheets (BP NSs) lies in the inherent instability, while it can be improved by surface modification strategies to a great extent. Considering the existing infirm BP NSs surface modification strategies, A mussels-inspired strong adhesive biomimetic peptide with azide groups for surface modification to increase the stability of BP NSs is synthesized. The azide groups on the peptide can quickly and precisely bind to the targeting ligand through click chemistry, solving the problem of nonspecificity of secondary modification of other mussel-mimicking materials. Besides, a catechol-Gd3+ coordination network is further constructed for magnetic resonance imaging (MRI) and inducing intracellular endo/lysosome escape. The fabricated BP-DOX@Gd/(DOPA)(4)-PEG-TL nanoplatform exhibits enhanced antitumor abilities through synergetic chemo/photothermal effects both in vitro and in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据