期刊
SMALL
卷 18, 期 22, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202200915
关键词
anti-bacteria; nanoparticles; pH-responsive capability; silver; tunable size
类别
资金
- National Natural Science Foundation of China [81970984, 82071164, 81771122, 81970985]
- Key research program of Sichuan Science and technology Department [2021YFS0052]
This study successfully synthesized silver nanoparticles with pH sensitive charge reversal and self-aggregation capacities, and applied them in animal models. The nanoparticles showed antibacterial effects, inhibited plaque biofilm formation, and improved inflammatory responses.
The rapid spread of drug-resistant pathogens threatens human health. To address the current antibacterial dilemma, the development of antibiotic-free strategies using nanotechnology is imperative. In this study, silver nanoparticles (Ag-P&C NPs) with pH-sensitive charge reversal and self-aggregation capacities are successfully synthesized. In the acidic microenvironment of bacterial biofilms, protonation of the surface peptide enhances the affinity of Ag-P&C NPs for bacteria, which can make Ag-P&C NPs prone to target and penetrate into biofilms, and the self-aggregated capacity helps Ag-P&C NPs remain in biofilms for a long time to disrupt bacterial biofilm formation. In addition, biocompatible Ag-P&C NPs are utilized in three types of bacteria-infected animal models. They exhibit an excellent performance in killing bacteria, inhibiting plaque biofilms, and ameliorating inflammatory responses. In conclusion, this study offers new insights into antibiotic-free antibacterial strategies, and exhibits promising application prospects.
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