4.6 Article

Fine-Tuned DenseNet-169 for Breast Cancer Metastasis Prediction Using FastAI and 1-Cycle Policy

期刊

SENSORS
卷 22, 期 8, 页码 -

出版社

MDPI
DOI: 10.3390/s22082988

关键词

DenseNet-169; computational histopathology; cancer; whole-slide images; lymph nodes; FastAI; 1-cycle policy; diagnostic odds ratio

资金

  1. National Research Foundation of Korea (NRF) - Korea government (MSIT) [2022R1C1C1004590]
  2. National Research Foundation of Korea [2022R1C1C1004590] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

This study introduces a new method for automated diagnosis and detection of metastases in breast cancer using the Fast AI framework and the 1-cycle policy, and compares it with previous methods. The proposed model has achieved an accuracy of over 97.4% and surpasses other state-of-the-art methods. Additionally, a mobile application has been developed for prompt diagnosis of metastases in early-stage cancer.
Lymph node metastasis in breast cancer may be accurately predicted using a DenseNet-169 model. However, the current system for identifying metastases in a lymph node is manual and tedious. A pathologist well-versed with the process of detection and characterization of lymph nodes goes through hours investigating histological slides. Furthermore, because of the massive size of most whole-slide images (WSI), it is wise to divide a slide into batches of small image patches and apply methods independently on each patch. The present work introduces a novel method for the automated diagnosis and detection of metastases from whole slide images using the Fast AI framework and the 1-cycle policy. Additionally, it compares this new approach to previous methods. The proposed model has surpassed other state-of-art methods with more than 97.4% accuracy. In addition, a mobile application is developed for prompt and quick response. It collects user information and models to diagnose metastases present in the early stages of cancer. These results indicate that the suggested model may assist general practitioners in accurately analyzing breast cancer situations, hence preventing future complications and mortality. With digital image processing, histopathologic interpretation and diagnostic accuracy have improved considerably.

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