The therapeutic potential of the neuroactive peptides of soluble amyloid precursor protein-alpha in Alzheimer’s disease and related neurological disorders

Effect of soluble amyloid precursor protein-alpha on adult hippocampal neurogenesis in a mouse model of Alzheimer’s disease

(2022) Shane M. Ohline et al.   Molecular Brain

A Systems View of the Heparan Sulfate Interactome

(2021) Alejandro Gómez Toledo et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Strategies for delivering therapeutics across the blood–brain barrier

(2021) Georg C. Terstappen et al.   NATURE REVIEWS DRUG DISCOVERY

Whether short peptides are good candidates for future neuroprotective therapeutics?

(2021) Renata Perlikowska   PEPTIDES

GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer’s disease

(2021) Joan Jiménez-Balado et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model

(2021) Kelly H. Forest et al.   Frontiers in Molecular Neuroscience

Effects of amyloid precursor protein peptide APP96-110, alone or with human mesenchymal stromal cells, on recovery after spinal cord injury

(2021) StuartI Hodgetts et al.   Neural Regeneration Research

The Unifying Hypothesis of Alzheimer’s Disease: Heparan Sulfate Proteoglycans/Glycosaminoglycans Are Key as First Hypothesized Over 30 Years Ago

(2021) Alan David Snow et al.   Frontiers in Aging Neuroscience

Deciphering the neuroprotective and neurogenic potential of soluble amyloid precursor protein alpha (sAPPα)

(2020) Nawab John Dar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain

(2020) William M. Pardridge   Frontiers in Aging Neuroscience

Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

(2020) Bruno P. Meloni et al.   Frontiers in Neurology

Liposome-based targeting of dopamine to the brain: a novel approach for the treatment of Parkinson’s disease

(2020) Meygal Kahana et al.   MOLECULAR PSYCHIATRY

Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety

(2020) Adam B. Edwards et al.   DRUG SAFETY

Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome

(2020) Sylvain D. Vallet et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Liposomal Carrier Conjugated to APP-Derived Peptide for Brain Cancer Treatment

(2020) Martin Gabay et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lentivirus-Mediated Expression of Human Secreted Amyloid Precursor Protein-Alpha Promotes Long-Term Induction of Neuroprotective Genes and Pathways in a Mouse Model of Alzheimer’s Disease

(2020) Margaret Ryan et al.   JOURNAL OF ALZHEIMERS DISEASE

Multidisciplinary approaches for targeting the secretase protein family as a therapeutic route for Alzheimer's disease

(2019) Nalini Schaduangrat et al.   MEDICINAL RESEARCH REVIEWS

Neuronal function of Alzheimer's protein

(2019) Martin Korte   SCIENCE

The secreted APP ectodomain sAPPα, but not sAPPβ, protects neurons against Aβ oligomer-induced dendritic spine loss and increased tau phosphorylation

(2019) Christian Tackenberg et al.   Molecular Brain

Dysregulation of CRMP2 Post-Translational Modifications Drive Its Pathological Functions

(2019) Aubin Moutal et al.   MOLECULAR NEUROBIOLOGY

Glutamate receptor trafficking and protein synthesis mediate the facilitation of ltp by secreted amyloid precursor protein-alpha

(2019) Bruce G. Mockett et al.   JOURNAL OF NEUROSCIENCE

CSF sAPPα and sAPPβ levels in Alzheimer’s Disease and Multiple Other Neurodegenerative Diseases: A Network Meta-Analysis

(2019) Wei Tang et al.   NEUROMOLECULAR MEDICINE

The blood-brain barrier: Physiology and strategies for drug delivery

(2019) Rucha Pandit et al.   ADVANCED DRUG DELIVERY REVIEWS

A C-terminal peptide from secreted amyloid precursor protein-α enhances long-term potentiation in rats and a transgenic mouse model of Alzheimer's disease

(2019) Jodi A. Morrissey et al.   NEUROPHARMACOLOGY

Amyloid, APP, and Electrical Activity of the Brain

(2019) Dimitri Hefter et al.   NEUROSCIENTIST

The Tripeptide RER Mimics Secreted Amyloid Precursor Protein-Alpha in Upregulating LTP

(2019) Jodi A. Morrissey et al.   Frontiers in Cellular Neuroscience

What Happens with the Circuit in Alzheimer's Disease in Mice and Humans?

(2018) Benedikt Zott et al.   Annual Review of Neuroscience

Therapeutic peptides for CNS indications: Progress and challenges

(2018) Bruce H. Morimoto   BIOORGANIC & MEDICINAL CHEMISTRY

The Blood Brain Barrier: A Review of its Anatomy and Physiology in Health and Disease

(2018) Yousra Sharif et al.   CLINICAL ANATOMY

IKK2/NF-κB signaling protects neurons after traumatic brain injury

(2018) Melanie Mettang et al.   FASEB JOURNAL

Proteoglycans in brain development and pathogenesis

(2018) Nancy B. Schwartz et al.   FEBS LETTERS

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade

(2018) Erika N. Cline et al.   JOURNAL OF ALZHEIMERS DISEASE

The amyloid precursor protein derivative, APP96-110, is efficacious following intravenous administration after traumatic brain injury

(2018) Stephanie L. Plummer et al.   PLoS One

Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity

(2018) Giuseppe Condomitti et al.   Frontiers in Molecular Neuroscience

Activation of the α-Secretase Processing of AβPP as a Therapeutic Approach in Alzheimer's Disease

(2018) Bruno Vincent et al.   JOURNAL OF ALZHEIMERS DISEASE

Rodent models for Alzheimer disease

(2018) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Protection against β-amyloid neurotoxicity by a non-toxic endogenous N-terminal β-amyloid fragment and its active hexapeptide core sequence

(2017) Kelly H. Forest et al.   JOURNAL OF NEUROCHEMISTRY

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

Analysis of peripheral amyloid precursor protein in Angelman Syndrome

(2016) Craig A. Erickson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms

(2016) Gabriella MacDougall et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

‘From past to future’ - deciphering the molecular basis of Alzheimer's disease through the pages of the Journal of Neurochemistry

(2016) Roberto Cappai   JOURNAL OF NEUROCHEMISTRY

Amyloid Precursor Protein Protects Neuronal Network Function after Hypoxia via Control of Voltage-Gated Calcium Channels

(2016) D. Hefter et al.   JOURNAL OF NEUROSCIENCE

Restoring Soluble Amyloid Precursor Protein α Functions as a Potential Treatment for Alzheimer's Disease

(2016) Ahsan Habib et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Neuroprotective Properties of the Amyloid Precursor Protein Following Traumatic Brain Injury

(2016) Stephanie Plummer et al.   Aging and Disease

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer’s disease mouse model

(2015) Romain Fol et al.   ACTA NEUROPATHOLOGICA

Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models

(2015) Bruno P Meloni et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3β signaling pathway

(2015) Juan Deng et al.   JOURNAL OF NEUROCHEMISTRY

Peptides and the blood–brain barrier

(2015) William A. Banks   PEPTIDES

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

(2015) Bruno P. Meloni et al.   PHARMACOLOGY & THERAPEUTICS

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Regulation of Presynaptic Ca2+, Synaptic Plasticity and Contextual Fear Conditioning by a N-terminal  -Amyloid Fragment

(2014) J. L. M. Lawrence et al.   JOURNAL OF NEUROSCIENCE

Time-dependent changes in gene expression induced by secreted amyloid precursor protein-alpha in the rat hippocampus

(2013) Margaret M Ryan et al.   BMC GENOMICS

Proteoglycans in the central nervous system: Role in development, neural repair, and Alzheimer's disease

(2013) Hao Cui et al.   IUBMB LIFE

The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96-110

(2013) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

(2013) Helena C. Christianson et al.   MATRIX BIOLOGY

sAPPα rescues deficits in amyloid precursor protein knockout mice following focal traumatic brain injury

(2012) Frances Corrigan et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

(2011) Frances Corrigan et al.   BRAIN RESEARCH

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-  Uptake

(2011) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links

(2011) D. K. Sokol et al.   NEUROLOGY

Secreted Human Amyloid Precursor Protein Binds Semaphorin 3a and Prevents Semaphorin-Induced Growth Cone Collapse

(2011) Margaret H. Magdesian et al.   PLoS One

Identification of novel N-terminal fragments of amyloid precursor protein in cerebrospinal fluid

(2009) Erik Portelius et al.   EXPERIMENTAL NEUROLOGY

Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway

(2008) Nidhi Gakhar-Koppole et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE