期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 138, 期 -, 页码 128-141出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2022.04.002
关键词
Drosophila; Innate immunity; Infection; Metabolism
In Drosophila melanogaster, the Toll and Imd signaling pathways are activated to combat pathogenic microbes and induce metabolic changes in the host. These immune-mediated metabolic phenotypes can either confer resistance or susceptibility to infection, and are influenced by variables such as sex, diet, and pathogen characteristics. Understanding the mechanisms by which the immune system regulates metabolism is a key focus for future research.
Infection with pathogenic microbes is a severe threat that hosts manage by activating the innate immune response. In Drosophila melanogaster, the Toll and Imd signaling pathways are activated by pathogen-associated molecular patterns to initiate cellular and humoral immune processes that neutralize and kill invaders. The Toll and Imd signaling pathways operate in organs such as fat body and gut that control host nutrient metabolism, and infections or genetic activation of Toll and Imd signaling also induce wide-ranging changes in host lipid, carbohydrate and protein metabolism. Metabolic regulation by immune signaling can confer resistance to or tolerance of infection, but it can also lead to pathology and susceptibility to infection. These immunometabolic phenotypes are described in this review, as are changes in endocrine signaling and gene regulation that mediate survival during infection. Future work in the field is anticipated to determine key variables such as sex, dietary nutrients, life stage, and pathogen characteristics that modify immunometabolic phenotypes and, importantly, to uncover the mechanisms used by the immune system to regulate metabolism.
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