Review
Oncology
Xuhui Tong, Rong Tang, Mingming Xiao, Jin Xu, Wei Wang, Bo Zhang, Jiang Liu, Xianjun Yu, Si Shi
Summary: This article discusses the molecular processes and effects of necroptosis, pyroptosis, ferroptosis, and cuproptosis on tumor cell proliferation and cancer metastasis, as well as the complex effects of these novel types of tumor cell death on the tumor microenvironment and regulated death of other cells in the microenvironment.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Qin Hu, Runtian Wang, Jiaxin Zhang, Qun Xue, Bo Ding
Summary: Tumor-associated neutrophils (TANs) with high expression of HMGB1 play a role in immune evasion and suppression of anti-tumor immune responses in the tumor microenvironment. The GATA2/HMGB1/TIM-3 axis is crucial in this process, and HMGB1-positive TANs could serve as potential indicators for clinical outcomes and immunotherapy effects in NSCLC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Immunology
Jing Liu, Minjing Hong, Yijia Li, Dan Chen, Yangzhe Wu, Yi Hu
Summary: Cell death plays a crucial role in modulating the tumor microenvironment and determining the outcomes of cancer therapy. It can have dual roles in promoting or inhibiting tumor growth and also regulates the accumulation of immune cells, contributing to fine-tuning tumor immunity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Cong Jiang, Xianglong Li, Fen Pan, Lele Zhang, Huansha Yu, Jing Zhang, Jinglin Zou, Tianyu Zhong, Dapeng Zhang, Yang Yang, Yongsheng Li, Peng Zhang
Summary: This article introduces a novel GSH-responsive nanomodulator that can reverse the immunosuppressive tumor microenvironment by inducing ferroptosis and pyroptosis, achieving cold tumor immunotherapy and lung metastasis inhibition. The nanomodulator releases SAS and DOX to induce ferroptosis and pyroptosis, promoting the maturation of DCs and elevation of CTLs, as well as the release of tumor-associated antigens. In vivo experiments validate the desirable tumor destruction and significant inhibition of primary tumors and distant lung metastases through the combination of this nanomodulator and PD-L1 antibodies.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Oncology
Youke Wang, Yali Wang, Jing Pan, Lu Gan, Jianxin Xue
Summary: This review summarizes the molecular mechanisms and recent research progress related to radiotherapy-induced ferroptosis, necroptosis, and pyroptosis in tumor cells, as well as discusses the role of tumor cells undergoing these types of cell death in immune activation after radiotherapy. It also highlights some unresolved questions on the association of radiotherapy with ferroptosis, necroptosis, and pyroptosis. This review can improve our current understanding of the relationship between radiotherapy and different cell death pathways and provide a theoretical framework to improve the therapeutic effect of tumor radiotherapy in the future.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Immunology
Chunmei Zhang, Ning Liu
Summary: This review summarizes the recent advances in ferroptosis, necroptosis, and pyroptosis in the occurrence, development, and therapeutic potential of ovarian cancer (OC).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Liangmin Fu, Jiahao Bao, Jinhui Li, Qiuyang Li, Hansen Lin, Yayun Zhou, Jiangbo Li, Yixuan Yan, Marvin E. Langston, Tianhao Sun, Songliang Guo, Xinwei Zhou, Yuhang Chen, Yujun Liu, Yiqi Zhao, Jun Lu, Yong Huang, Wei Chen, Benjamin Chung, Junhang Luo
Summary: This study investigated the expression patterns of necroptosis and pyroptosis related genes in ccRCC and constructed an NPG score prognostic model, which showed good predictive capabilities in ccRCC patients and had potential multifunctionality in clinical therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Pan Juncheng, Adrien Joseph, Antoine Lafarge, Isabelle Martins, Florine Obrist, Jonathan Pol, Ester Saavedra, Sijing Li, Allan Sauvat, Giulia Cerrato, Sarah Levesque, Marion Leduc, Oliver Kepp, Sylvere Durand, Fanny Aprahamian, Nitharsshini Nirmalathansan, Judith Michels, Guido Kroemer, Maria Castedo
Summary: This study found that high activity of PARP1 in non-small cell lung cancer cells affects the tumor microenvironment, leading to compromised immunosurveillance and reduced infiltration of cytotoxic T lymphocytes.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Critical Care Medicine
Mengdi Qu, Yanghanzhao Wang, Zhiyun Qiu, Shuainan Zhu, Kefang Guo, Wankun Chen, Changhong Miao, Hao Zhang
Summary: Sepsis is a major global health problem and a leading cause of death. Despite progress in identification and management, the morbidity and mortality rates remain high. Recent research on regulated cell death (RCD) in sepsis has gained attention as dying cells release danger signals that contribute to inflammation and worsening of sepsis, providing a new direction for treatment strategies.
Review
Cell Biology
Jian Yang, Shasha Hu, Yangyang Bian, Jiangling Yao, Dong Wang, Xiaoqian Liu, Zhengdong Guo, Siyuan Zhang, Lei Peng
Summary: New research has shown that the development of osteoarthritis is influenced by different mechanisms of cell death and types of cytokines. Understanding the interaction between cytokines, cell death processes, and osteoarthritis is crucial for better understanding the pathogenesis and progression of the disease.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Sheng Gao, Yun Zhang, Meixia Zhang
Summary: This article summarizes the mechanisms of three types of regulated cell death (RCD) in diabetic retinopathy (DR) and analyzes the recent advances in the association between novel RCD forms and DR. These findings provide new insights into the underlying pathogenic mechanisms of DR and propose potential therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Jiaqi Zhu, Jinjie Wang, Tianyi Wang, Hao Zhou, Mingming Xu, Jiliang Zha, Chen Feng, Zihao Shen, Yun Jiang, Jianle Chen
Summary: This study explores the impact of necroptosis on tumor development in non-small cell lung cancer (NSCLC) and identifies prognostic genes. The results show that the construction of prognostic risk models has stable validity in guiding immunotherapy and chemotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Kai Nie, Lin Zhu, Yinan Chen, Luodan Yu, Meiqi Chang, Yu Chen, Hong Yu
Summary: A polymetallic Cu0.5Mn0.5Fe2O4 (CMF) nanozyme has been engineered to generate a large amount of center dot OH, amplify reactive oxygen species production, elevate oxidative stress level and induce cell pyroptosis. Exogenous ultrasound irradiation further amplifies and improves therapeutic effect in treating lung cancer.
Article
Oncology
Shuyue Zheng, Xin-Yuan Guan
Summary: Ferroptosis is a cell death that occurs due to the accumulation of ferrous ions and lipid peroxidation in tumor cells. Targeting ferroptosis as a novel strategy for anti-tumor therapy involves regulating various metabolic and immune elements. This review highlights the mechanism of ferroptosis, its interaction with cancer and tumor immune microenvironment, particularly the relationship between immune cells and ferroptosis. Additionally, it discusses the latest preclinical progress in combining ferroptosis-targeted drugs with immunotherapy, and the optimal conditions for their combined use, providing insight into the potential value of ferroptosis in cancer immunotherapy.
Article
Medicine, General & Internal
Yi-Han Zuo, Wei-Na Gao, Ya-Jia Xie, Sheng-Yong Yang, Jin-Tai Zhou, Hai-Hai Liang, Xing-Xing Fan
Summary: PKC delta is identified as a critical factor in the non-inflamed tumor microenvironment (TME) of EGFR-mutated lung cancer. Inhibition of PKC delta enhances the infiltration of immune cells into tumors and increases the sensitivity of tumors to immune checkpoint blockade therapy.
Article
Cell Biology
Xiaofei Wang, Guang Cheng, Yu Miao, Fangyuan Qiu, Lugen Bai, Zhongfei Gao, Yunning Huang, Liru Dong, Xing Niu, Xin Wang, Yuyang Li, Hui Tang, Yuanyi Xu, Xudong Song
Summary: The study revealed that Piezo1 plays a crucial role in gastric cancer omentum metastasis by promoting cell proliferation and migration, impacting intracellular Ca2+ influx through upregulation of HIF-1α, hence affecting tumor growth and metastasis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Lijie Chen, Xing Niu, Xue Qiao, Sai Liu, Hongmei Ma, Xueqing Shi, Xuemei He, Ming Zhong
Summary: This study provides a comprehensive analysis of the interplay between autophagy and ferroptosis in SCCs, and their synergistic roles in manipulating the immunological TME.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhuning Wang, Junqiao Yao, Tengyu Dong, Xing Niu
Summary: This study discovered a cuproptosis-relevant lncRNA signature that can efficiently predict clinical outcomes in lung adenocarcinoma (LUAD) patients. The high-risk subset displayed higher genomic alterations, immunological features, and stemness indexes, indicating potential benefits from immunotherapy. This research provides important information for personalized therapy in LUAD.
JOURNAL OF IMMUNOLOGY RESEARCH
(2022)
Article
Neurosciences
Ming -Xi Zhu, Xiao-Fei Ma, Xing Niu, Gui-bo Fan, Yan Li
Summary: This article discusses the regulatory mechanisms of mitochondrial unfolded protein response (UPRmt) in ischemia-reperfusion injury and reviews the recent studies on the roles and mechanisms of UPRmt signaling in heart, brain, kidney, and liver ischemia-reperfusion injury.
Article
Biochemistry & Molecular Biology
Yu Tian, Haijuan Xiao, Yanhui Yang, Pingping Zhang, Jiahui Yuan, Wei Zhang, Lijie Chen, Yibao Fan, Jinze Zhang, Huan Cheng, Tingwei Deng, Lin Yang, Weiwei Wang, Guoyong Chen, Peiqin Wang, Peng Gong, Xing Niu, Xianbin Zhang
Summary: This study conducted a comprehensive analysis of the crosstalk between 5mC and m(6)A regulators in hepatocellular carcinoma (HCC) and established a scoring system to characterize the interactions. The results showed that 5mC and m(6)A regulators interacted in HCC and were associated with clinical outcomes and treatment response. Furthermore, potential therapeutic drugs and druggable targets were identified.
Review
Chemistry, Multidisciplinary
Shuangqi Yu, Lijie Chen, Hongyu Xu, Shengrong Long, Jiazhi Jiang, Wei Wei, Xing Niu, Xiang Li
Summary: The diagnosis and treatment of glioblastoma face several obstacles, but combining multiple methods can provide benefits. Nanomaterials and drug combinations can improve treatment outcomes and reduce side effects. This review discusses the progress and challenges of glioblastoma diagnosis and treatment, as well as the potential of nanomedicine in this field.
FRONTIERS IN CHEMISTRY
(2022)
Article
Oncology
Ming-Xi Zhu, Si-Qi Sun, Gui-Bo Fan, A-Yang Zhao, Xing Niu, Si-Hua Qi, Yan Li
Summary: This study conducted a bibliometric analysis on the mitochondrial unfolded protein response (UPRmt) and found that UPRmt research has gone through the stages of infancy and rapid growth. The United States and China have made the largest contributions to UPRmt research, with Harvard University being the most influential institution and Johan Auwerx and CM Haynes being the most prolific authors. The research areas of UPRmt mainly include biochemistry/molecular biology and cell biology. Strengthening cooperation and exchanges between countries, institutions, and authors will promote the development of this field.
ANNALS OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yong Xi, Yaxing Shen, Lijie Chen, Lijie Tan, Weiyu Shen, Xing Niu
Summary: Esophageal carcinoma is a highly fatal malignancy, and its progression and tumor microenvironment remodeling are driven by metabolic reprogramming. Exosomes play a crucial role in transferring molecules that modulate metabolic reprogramming and have promising clinical applications in esophageal carcinoma.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Immunology
Yong Xi, Lijie Chen, Jian Tang, Bentong Yu, Weiyu Shen, Xing Niu
Summary: Immunogenic cell death (ICD) is a unique mode of cell death that triggers long-term protective antitumor immune responses by releasing immunogenic damage-associated molecular patterns (DAMPs) and tumor-associated antigens. Amplifying the "eat me" signal during the tumor ICD cascade is critical for cancer immunotherapy.
IMMUNOLOGICAL REVIEWS
(2023)
Letter
Medicine, General & Internal
Jin Zhou, Yu Zhang, Ke Mo, Herbert Newbert, Xicheng Song
Article
Oncology
Zhe Wang, Yang Liu, Xing Niu
Summary: Recently, artificial intelligence approaches such as machine learning and deep learning have been applied to improve various aspects of gastric cancer management, including risk surveillance, diagnosis accuracy, survival prediction, and treatment outcomes. However, most artificial intelligence models are still in a research-based format and have limited value in clinical practice.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Xing Niu, Biying Huang, Jing Yang, Xue Qiao, Lijie Chen, Jinwen Liu, Jingping Xu, Ming Zhong
Summary: Odontogenic carcinosarcoma is a rare malignant tumor characterized by malignant epithelial and mesenchymal components, primarily occurring in the jaws with malignant clinical manifestations. This case report describes a 58-year-old woman with odontogenic carcinosarcoma involving dentinoid in the left maxilla, who underwent successful tumor resection and showed no signs of disease or recurrence after a 4-year follow-up. This case represents the first reported instance of odontogenic carcinosarcoma with dentinoid and highlights the clinical, morphological, and immunohistochemical characteristics of this unique tumor.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Xue Qiao, Xing Niu, Jiayi Liu, Lijie Chen, Yan Guo, Ming Zhong
Summary: Ameloblastoma is a common odontogenic epithelial tumor with various biological behaviors. Two cases of unusually large solid ameloblastomas were reported, with detected expression of epithelial-mesenchymal transition-related genes and HRAS gene single nucleotide polymorphisms, providing possible molecular evidence of mesenchymal morphological changes in ameloblastoma. Detailed analysis of these cases may deepen understanding of this rare disease and offer promising targets for future targeted therapy.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Oncology
Ruizhen Ren, Yuanna Du, Xing Niu, Rukun Zang
Summary: In thyroid cancer, ZFPM2-AS1 acts as an oncogene mediated by STAT1, weakening the inhibitory effect of miR-515-5p on TUSC3 and promoting cancer progression. Thus, ZFPM2-AS1 may serve as a potential biomarker for thyroid cancer.