Article
Cardiac & Cardiovascular Systems
Tomoki Sakata, Shin Watanabe, Renata Mazurek, Spyros Mavropoulos, Francisco Romeo, Kelly P. Yamada, Kiyotake Ishikawa
Summary: This study found that mechanical left ventricular unloading has variable effects on blood flow, with overall improvement in infarct area but not consistent across all individuals. Factors such as cardiac output, pulmonary arterial wedge pressure, left atrial pressure, and measures of left ventricular function were significantly associated with changes in infarct blood flow. Steeper end-diastolic pressure-volume relationship slope and lower maximum dP/dt were independent predictors of infarct blood flow improvement after LV unloading.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gustavo Neves de Araujo, Rafael Beltrame, Guilherme Pinheiro Machado, Julia Luchese Custodio, Andre Zimerman, Anderson Donelli da Silveira, Fernado Luis Scolari, Luiz Carlos Corsetti Bergoli, Sandro Cadaval Goncalves, Felipe Pereira Lima Marques, Felipe Costa Fuchs, Marco Vugman Wainstein, Rodrigo Vugman Wainstein
Summary: The study found a weak correlation between LVEDP and LUS in ST-segment-elevation myocardial infarction patients undergoing primary percutaneous coronary intervention. In multivariable analysis, LUS was significantly associated with in-hospital major adverse cardiovascular events, new cardiogenic shock, and in-hospital mortality, while LVEDP showed no significant association with these outcomes.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Cardiac & Cardiovascular Systems
Atsuko Uema, Yuma Tamura, Tokuhisa Uejima, Megumi Hoshiai, Asuka Ueno, Moeko Nagao, Takashi Tomoe, Shoya Ono, Eikou Maeno, Satoshi Mizuguchi, Atsuhiko Kawabe, Takushi Sugiyama, Takanori Yasu
Summary: This study aimed to explore the mechanism underlying early diastolic mitral regurgitation (EDMR) in patients with left ventricular (LV) aneurysms after anterior myocardial infarction (AMI) by assessing the intraventricular pressure difference using vector flow mapping. The study found that EDMR in LV aneurysm may be due to a prolonged diastolic time ratio leading to prolonged pressure inversion in the LV during early diastole.
Article
Medicine, General & Internal
Jae-Hwan Lee, Jungai Kim, Byung Joo Sun, Sung Ju Jee, Jae-Hyeong Park
Summary: Cardiac rehabilitation (CR) is associated with improved symptoms and survival in patients with acute myocardial infarction (AMI). The study found that CR significantly improved diastolic function in AMI patients, with CR group showing the best diastolic function parameters at follow-up echocardiographic examinations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yan Tang, Suzhen Liu, Yunming Shi, Tian He, Xuejing Sun, Mingxing Wu, Zhiliu Peng, Fei Gui, Hong Yuan, Yao Lu, Jingjing Cai, Yuanyuan Chen
Summary: This study found that maintaining a systolic blood pressure (SBP) of 90-130 mmHg and a diastolic blood pressure (DBP) of 60-80 mmHg during hospitalization may be beneficial for long-term outcomes in patients with acute left ventricular myocardial infarction (AMI).
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hadar Ben-Arzi, Arka Das, Christopher Kelly, Rob J. van der Geest, Sven Plein, Erica Dall'Armellina
Summary: This study investigated the longitudinal changes in intraventricular flow post-STEMI and its predictive relevance of long-term cardiac remodeling. The results showed that patients with reduced ejection fraction retained significantly higher systolic kinetic energy, while preserved ejection fraction patients had persistently higher peakE-wave kinetic energy throughout the study period.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Annette M. Maznyczka, Peter J. McCartney, Keith G. Oldroyd, Mitchell Lindsay, Margaret McEntegart, Hany Eteiba, J. Paul Rocchiccioli, Richard Good, Aadil Shaukat, Keith Robertson, Christopher J. Malkin, John P. Greenwood, James M. Cotton, Stuart Hood, Stuart Watkins, Damien Collison, Lynsey Gillespie, Thomas J. Ford, Robin A. P. Weir, Alex McConnachie, Colin Berry
Summary: The combination of IMR and LVEDP has incremental value for risk stratification following primary percutaneous coronary intervention, and is predictive of major adverse cardiac events.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Arshad A. Khan, Mohammed S. Al-Omary, Nicholas J. Collins, John Attia, Andrew J. Boyle
Summary: The study aimed to assess the natural history and prognostic value of elevated LVEDP in STEMI patients after thrombolysis. Results showed that patients with higher LVEDP were more likely to experience mortality and heart failure admissions. In patients undergoing successful thrombolysis for STEMI, LVEDP decreased slightly from initial to pre-hospital discharge measurements.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Instruments & Instrumentation
Mengmeng Zhu, Yujie Gao, Jun Wang, Yingqian Ge, Yinsu Zhu, Xiaomei Zhu, Yi Xu
Summary: The feasibility of using CCTA-derived strain parameters to detect regional myocardial dysfunction in CAD patients with preserved LVEF was evaluated. Radial and circumferential strain have the potential ability to distinguish myocardial ischemia from infarction, and normal from ischemic myocardium.
JOURNAL OF X-RAY SCIENCE AND TECHNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Murat Cap, Emrah Erdogan, Ali Karagoz, Ozden Savas Den Hartigh, Rezzan Deniz Acar, Cetin Gecmen, Tuba Unkun, Cem Dogan, Busra Guvendi, Bernas Altintas, Cagatay Onal, Cihangir Kaymaz, Nihal Ozdemir
Summary: The study showed a significant relationship between left ventricular end-diastolic pressure (LVEDP) and scintigraphic infarct size (IS), with IS increasing as LVEDP values rose. However, there was no correlation between LVEDP and global longitudinal strain (GLS).
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ahmet Demirkiran, Mariella E. C. J. Hassell, Pankaj Garg, Mohammed S. M. Elbaz, Ronak Delewi, John P. Greenwood, Jan J. Piek, Sven Plein, Rob J. van der Geest, Robin Nijveldt
Summary: In this study, the researchers used 4D flow cardiovascular magnetic resonance (CMR) to investigate the differences in left ventricular (LV) flow between chronic myocardial infarction (MI) patients with and without left ventricular thrombus (LVT), as well as healthy controls. They found that MI patients with LVT had altered LV flow components, irregular vorticity vector fields, and changes in diastolic vortex ring geometric properties compared to those without LVT. These findings suggest potential links between global LV flow characteristics and LVT formation.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Peripheral Vascular Disease
Liyun Fu, Qinyun Ruan, Ziling You, Huimei Huang, Yupeng Chen, Sheng Cheng, Lei Yan, Huang'e Cai, Yali Chen, Dongmei Lin, Huizhen Chen, Chunyan Huang
Summary: This study investigated the characteristics of left ventricular multidirectional strain during different stages of heart dysfunction in hypertensive rats and found that pathological myocardial fibrosis associated with hypertension develops from the inner to outer layer of myocardium. Impairment of myocardial deformation, especially in the longitudinal strain, is involved in the development of cardiac dysfunction.
AMERICAN JOURNAL OF HYPERTENSION
(2022)
Article
Peripheral Vascular Disease
Makiko Kimura, Haruki Sekiguchi, Ken Shimamoto, Masatoshi Kawana, Yousuke Takemura, Nobuhisa Hagiwara, Junich Yamaguchi
Summary: This study analyzed the relationship between left ventricular diastolic dysfunction and metabolic syndrome (MetS) as well as other cardiovascular risk factors, and identified risks for LV diastolic dysfunction. The study found that in healthy postmenopausal women, high-normal diastolic blood pressure was the only independent risk factor for LV diastolic dysfunction.
HYPERTENSION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Ezgi Berberoglu, Christian T. Stoeck, Philippe Moireau, Sebastian Kozerke, Martin Genet
Summary: The study found that radial strain is more sensitive to image resolution and noise, while the quantification of circumferential and longitudinal strains is robust. There is a need for higher-resolution 3D tagged MRI to achieve sufficient accuracy in radial strain quantification.
Letter
Neurosciences
David C. Poole, Harry B. Rossiter, George A. Brooks, L. Bruce Gladden
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Neurosciences
David C. Poole, Harry B. Rossiter, George A. Brooks, L. Bruce Gladden
Summary: The anaerobic threshold (AT) is a controversial concept in exercise physiology and medicine, originally thought to be caused by muscle anoxia but now understood to be a response to increased glycolytic flux. Lactate is now appreciated as an important energy source and signaling molecule, with non-invasive estimation of LT using the gas exchange threshold remaining important in exercise training and in the clinic.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Biochemistry & Molecular Biology
David C. Poole, Yutaka Kano, Shunsaku Koga, Timothy Musch
Summary: Krogh's pioneering research established the foundation of muscle microcirculation and highlighted the crucial role of capillaries in muscle activity and the promotion of blood-myocyte oxygen flux.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Physiology
Richie P. Goulding, Dai Okushima, Yoshiyuki Fukuoka, Simon Marwood, Narihiko Kondo, David C. Poole, Thomas J. Barstow, Shunsaku Koga
Summary: The study found that during exercise in the supine position, there is an increase in deoxygenation in superficial muscles, but the deep muscles maintain a stable level of deoxygenation. This suggests that deep muscles are able to defend the balance between oxygen delivery and utilization against reduced perfusion pressure during supine exercise.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Neurosciences
Trenton D. Colburn, Ramona E. Weber, Kiana M. Schulze, K. Sue Hageman, Andrew G. Horn, Brad J. Behnke, David C. Poole, Timothy I. Musch
Summary: The study demonstrated sex differences in vascular K-ATP channel function in rats, suggesting potential exacerbation of exercise intolerance and morbidity with oral sulphonylureas, especially in premenopausal females. There was a greater reduction in muscle blood flow and exercise tolerance observed in female rats compared to males when treated with glibenclamide, highlighting the importance of considering sex-related effects in medication.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Review
Physiology
David C. Poole, Timothy I. Musch, Trenton D. Colburn
Summary: This article delves into the process of oxygen transport in the human body, challenging some traditional notions and offering a redefined model of muscle oxygen transport.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramona E. Weber, Kiana M. Schulze, Trenton D. Colburn, Andrew G. Horn, K. Sue Hageman, Carl J. Ade, Stephanie E. Hall, Peter Sandner, Timothy I. Musch, David C. Poole
Summary: In heart failure with reduced ejection fraction, dysfunction of the sGC pathway impairs skeletal muscle arteriolar vasodilation and oxygen uptake. The use of sGC activators improves blood flow dynamics and oxygen uptake, providing a potential therapeutic approach for HFrEF.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Physiology
Carl J. Ade, Vanessa-Rose G. Turpin, Shannon K. Parr, Stephen T. Hammond, Zachary White, Ramona E. Weber, Kiana M. Schulze, Trenton D. Colburn, David C. Poole
Summary: The study found that wearing masks during exercise may increase end-expired peri-oral %CO2 and decrease %O2, but did not impact arterial oxygen saturation. Ratings of dyspnea increased, but maximal exercise capacity was not compromised and primary cardiovascular responses remained unchanged during submaximal exercise.
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
(2021)
Letter
Sport Sciences
Ryan M. Broxterman, Jesse C. Craig, Brett S. Kirby
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Physiology
Jesse C. Craig, Corey R. Hart, Gwenael Layec, Oh Sung Kwon, Russell S. Richardson, Joel D. Trinity
Summary: This study found that patients with peripheral artery disease (PAD) have an exaggerated mean arterial blood pressure (MAP) response to exercise, likely driven by inflammation and oxidative stress. However, the blood flow response to exercise in patients with PAD remains equivocal.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2022)
Article
Physiology
Barbora Piknova, Mary N. N. Woessner, Joaquin Ortiz de Zevallos, William E. E. Kraus, Mitch D. D. VanBruggen, Alan N. N. Schechter, Jason D. D. Allen
Summary: Skeletal muscle may act as a reservoir for N-oxides following inorganic nitrate supplementation. This study aimed to investigate the effects of 12-week exercise training combined with oral inorganic nitrate supplementation on plasma and skeletal muscle nitrate and nitrite concentrations, as well as exercise performance, in individuals with peripheral artery disease (PAD). The results showed that there was no substantial gradient of nitrate (or nitrite) from skeletal muscle to plasma, suggesting a lack of reservoir-like function in participants with PAD. Oral nitrate supplementation increased skeletal muscle nitrate but not nitrite. Furthermore, there was a correlation between plasma and muscle nitrate concentration, indicating potential inter-compartmental communication. However, muscle nitrate and nitrite concentrations did not contribute to exercise performance in patients with PAD.
PHYSIOLOGICAL REPORTS
(2022)
Article
Physiology
Caitlin C. Fermoyle, D. Taylor La Salle, Jeremy K. Alpenglow, Jesse C. Craig, Catherine L. Jarrett, Ryan M. Broxterman, Alec I. McKenzie, David E. Morgan, Nathaniel M. Birgenheier, Walter Wray, Russell S. Richardson, Joel D. Trinity
Summary: The age-related increase in a-adrenergic tone may contribute to decreased leg vascular conductance both at rest and during exercise in the old. However, the effect on passive leg movement-induced leg vascular conductance, which is markedly attenuated in this population, is unknown.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeremy K. Alpenglow, Kanokwan Bunsawat, Michael A. Francisco, Jesse C. Craig, Jarred J. Iacovelli, John J. Ryan, D. Walter Wray
Summary: Data from this study suggest that functional sympatholysis, or the ability to adequately attenuate sympathetic nervous system (SNS)-mediated vasoconstriction during exercise, is impaired in patients with heart failure with preserved ejection fraction (HFpEF). These observations extend the current understanding of HFpEF pathophysiology by implicating inadequate functional sympatholysis as an important contributor to reduced exercising muscle blood flow in this patient group.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Jason D. Allen
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Article
Physiology
Daniel M. Hirai, Ayaka Tabuchi, Jesse C. Craig, Trenton D. Colburn, Timothy Musch, David C. Poole
Summary: Inhibition of K-ATP channels reduces RBC flow and hemodynamics in skeletal muscle capillaries, indicating their important role in regulating microvascular hemodynamics and gas exchange in resting skeletal muscle.
PHYSIOLOGICAL REPORTS
(2021)
