Cyclooxygenase-2 contributes to diabetic nephropathy through glomerular EP4 receptor

Targeting angiogenesis and lymphangiogenesis in kidney disease

(2020) Katsuyuki Tanabe et al.   Nature Reviews Nephrology

The single-cell transcriptomic landscape of early human diabetic nephropathy

(2019) Parker C. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Renoprotective effects of the novel prostaglandin EP4 receptor-selective antagonist ASP7657 in 5/6 nephrectomized chronic kidney disease rats

(2018) Kazuhiko Mizukami et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

EP4 inhibition attenuates the development of diabetic and non-diabetic experimental kidney disease

(2017) Karina Thieme et al.   Scientific Reports

Macrophage Cyclooxygenase-2 Protects Against Development of Diabetic Nephropathy

(2016) Xin Wang et al.   DIABETES

A dual COX-2/sEH inhibitor improves the metabolic profile and reduces kidney injury in Zucker diabetic fatty rat

(2016) Md. Abdul Hye Khan et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Prostanoids regulate angiogenesis acting primarily on IP and EP 4 receptors

(2015) Khuyen Gia Hoang et al.   MICROVASCULAR RESEARCH

COX-2 but Not mPGES-1 Contributes to Renal PGE2 Induction and Diabetic Proteinuria in Mice with Type-1 Diabetes

(2014) Zhanjun Jia et al.   PLoS One

Targeted Glomerular Angiopoietin-1 Therapy for Early Diabetic Kidney Disease

(2013) C. Dessapt-Baradez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6

(2013) Riyaz Mohamed et al.   LABORATORY INVESTIGATION

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Vegfa Protects the Glomerular Microvasculature in Diabetes

(2012) G. A. Sivaskandarajah et al.   DIABETES

Associations of kidney disease measures with mortality and end-stage renal disease in individuals with and without diabetes: a meta-analysis

(2012) Caroline S Fox et al.   LANCET

PGE2 promotes angiogenesis through EP4 and PKA C  pathway

(2011) Y. Zhang et al.   BLOOD

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

(2011) Marie Jeansson et al.   JOURNAL OF CLINICAL INVESTIGATION

A Maladaptive Role for EP4 Receptors in Podocytes

(2010) E. M. Stitt-Cavanagh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endothelial dysfunction as a potential contributor in diabetic nephropathy

(2010) Takahiko Nakagawa et al.   Nature Reviews Nephrology

Reduction of Renal Superoxide Dismutase in Progressive Diabetic Nephropathy

(2009) H. Fujita et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Markers of glycemic control in the mouse: comparisons of 6-h- and overnight-fasted blood glucoses to Hb A1c

(2008) Byoung Geun Han et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Physiological Regulation of Prostaglandins in the Kidney

(2007) Chuan-Ming Hao et al.   Annual Review of Physiology