SHAPE-enabled fragment-based ligand discovery for RNA

Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery

(2022) Meredith J. Zeller et al.   ACS Chemical Biology

Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS‐CoV‐2 Genome

(2021) Sridhar Sreeramulu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Riboswitches for Controlled Expression of Therapeutic Transgenes Delivered by Adeno-Associated Viral Vectors

(2021) Zachary J. Tickner et al.   Pharmaceuticals

Monitoring RNA dynamics in native transcriptional complexes

(2021) Adrien Chauvier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guidelines for SHAPE Reagent Choice and Detection Strategy for RNA Structure Probing Studies

(2019) Steven Busan et al.   BIOCHEMISTRY

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Quantitative metrics for drug–target ligandability

(2018) Sinisa Vukovic et al.   DRUG DISCOVERY TODAY

Principles for targeting RNA with drug-like small molecules

(2018) Katherine Deigan Warner et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting noncoding RNAs in disease

(2017) Brian D. Adams et al.   JOURNAL OF CLINICAL INVESTIGATION

Translational control and Rho-dependent transcription termination are intimately linked in riboswitch regulation

(2017) Laurène Bastet et al.   NUCLEIC ACIDS RESEARCH

Accurate detection of chemical modifications in RNA by mutational profiling (MaP) with ShapeMapper 2

(2017) Steven Busan et al.   RNA

Riboswitch diversity and distribution

(2017) Phillip J. McCown et al.   RNA

Transcriptional pausing at the translation start site operates as a critical checkpoint for riboswitch regulation

(2017) Adrien Chauvier et al.   Nature Communications

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

The ways and means of fragment-based drug design

(2016) Bradley C. Doak et al.   PHARMACOLOGY & THERAPEUTICS

Targeting Influenza A Virus RNA Promoter

(2015) Angel Bottini et al.   Chemical Biology & Drug Design

Selective 2′-hydroxyl acylation analyzed by primer extension and mutational profiling (SHAPE-MaP) for direct, versatile and accurate RNA structure analysis

(2015) Matthew J Smola et al.   Nature Protocols

Fragment based search for small molecule inhibitors of HIV-1 Tat-TAR

(2014) Mirco Zeiger et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

(2014) Thomas R. Cech et al.   CELL

Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically

(2014) Katherine Deigan Warner et al.   CHEMISTRY & BIOLOGY

RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP)

(2014) Nathan A Siegfried et al.   NATURE METHODS

Novel cis-Acting Element within the Capsid-Coding Region Enhances Flavivirus Viral-RNA Replication by Regulating Genome Cyclization

(2013) Z.-Y. Liu et al.   JOURNAL OF VIROLOGY

The 'rule of three' for fragment-based drug discovery: where are we now?

(2013) Harren Jhoti et al.   NATURE REVIEWS DRUG DISCOVERY

Quantifying the chemical beauty of drugs

(2012) G. Richard Bickerton et al.   Nature Chemistry

Probing riboswitch–ligand interactions using thiamine pyrophosphate analogues

(2012) Liuhong Chen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Recent Advances in Developing Small Molecules Targeting RNA

(2011) Lirui Guan et al.   ACS Chemical Biology

Compound Design by Fragment-Linking

(2011) Osamu Ichihara et al.   Molecular Informatics

A Fragment-Based Approach to Identifying Ligands for Riboswitches

(2010) Liuhong Chen et al.   ACS Chemical Biology

RNAstructure: software for RNA secondary structure prediction and analysis

(2010) Jessica S Reuter et al.   BMC BIOINFORMATICS

Entropic Contribution to the Linking Coefficient in Fragment Based Drug Design: A Case Study

(2010) Valentina Borsi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment screening against the thiamine pyrophosphate riboswitchthiM

(2010) Elena Cressina et al.   Chemical Science

What is Cooperativity?

(2009) Christopher A. Hunter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Centrality of RNA

(2009) Phillip A. Sharp   CELL

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Structural Basis of Thiamine Pyrophosphate Analogues Binding to the Eukaryotic Riboswitch

(2008) Stéphane Thore et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Traversing the coordination chemistry and chemical biology of hydroxamic acids

(2007) Rachel Codd   COORDINATION CHEMISTRY REVIEWS