Article
Pharmacology & Pharmacy
Xuele Liu, Minyao Ge, Xinyu Zhai, Yang Xiao, Yaheng Zhang, Ziling Xu, Zhiguang Zhou, Zubing Mei, Xuejun Yang
Summary: This study aimed to update the evidence on the efficacy of traditional Chinese medicine (TCM) in treating diabetic kidney disease (DKD). The results showed that TCM combined with Western medicine significantly improved renal function indices, blood glucose, and lipid profiles compared to Western medicine alone.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Wei Mao, Nizhi Yang, Lei Zhang, Chuang Li, Yifan Wu, Wenwei Ouyang, Peng Xu, Chuan Zou, Chunpeng Pei, Wei Shi, Jihong Zhan, Hongtao Yang, Hongyu Chen, Xiaoqin Wang, Yun Tian, Fang Yuan, Wei Sun, Guoliang Xiong, Ming Chen, Jianguo Guan, Shuifu Tang, Chunyan Zhang, Yuning Liu, Yueyi Deng, Qizhan Lin, Fuhua Lu, Weihong Hong, Aicheng Yang, Jingai Fang, Jiazhen Rao, Lixin Wang, Kun Bao, Feng Lin, Yuan Xu, Zhaoyu Lu, Guobin Su, La Zhang, David W. Johnson, Daixin Zhao, Haijing Hou, Lizhe Fu, Xinfeng Guo, Lihong Yang, Xindong Qin, Zehuai Wen, Xusheng Liu
Summary: The study found that Bupi Yishen Formula may have renoprotective effects in non-diabetic patients with CKD4 in the first 12 weeks and over the 48-week duration, with a lower risk of complications. However, longer follow-up is needed to evaluate the long-term effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yuqing Hu, Sichun Gu, Xiaolei Yuan, Hui Li, Canxing Yuan, Qing Ye
Summary: This study aims to evaluate the therapeutic effect of treating Parkinson's disease at different stages using traditional Chinese medicine and to provide evidence for the development of a standardized scheme of diagnosis and treatment.
Article
Gastroenterology & Hepatology
Zhe Li, Lin Tao, Sheng-Sheng Zhang, Xiao-Hong Sun, Su-Ning Chen, Jing Wu
Summary: The modified Xiaochaihu Decoction (MXD) demonstrated similar therapeutic effects to omeprazole in mild-to-moderate GERD patients, potentially due to increased lower esophageal sphincter pressure and reduced ineffective swallowing.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean -Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin
Summary: This study aimed to explore the satisfaction of patienst with DKD visiting TCM physicians and its association with socio-economic characteristics. Findings suggest that ethnicity, types of housing, previous TCM experience, and duration of follow-up with TCM physicians may affect the satisfaction scores of DKD patients.
Review
Cardiac & Cardiovascular Systems
Bo Liang, Ning Gu
Summary: Traditional Chinese medicine has a long history and is widely used in clinical practice, but its role in the prevention and treatment of coronary artery disease remains unclear due to lack of scientific evidence. Randomized controlled trials have shown that traditional Chinese medicine can be used as a complementary method in managing coronary artery disease, with similar safety profile to conventional medications. Further research with long-term endpoints is needed to fully assess its safety and efficacy.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Plant Sciences
Jun Feng, Shuang Zhou, Qin Xie, Tingrong Huang, Xiaoming Xu, Daixing Zhou, Wen Zhang, Shuting Sun, Xudong Liu, Xinxin Wu, Jinhua Che, Tian Fan, Dengxiu Zou, Junshuai Wang, Daqian Zhan, Dan Peng, Yikuan Feng, Gang Yu, Zuobiao Yuan, Bangjiang Fang
Summary: The study demonstrated that using Shenhuang Granule (SHG) in conjunction with standard care for treating patients with severe/critical COVID-19 can significantly reduce mortality rates and improve lymphocyte levels, while decreasing adverse events.
Review
Urology & Nephrology
Xuexun Chen, Xuan Li, Bo Cao, Xinping Chen, Kexin Zhang, Fang Han, Chengxia Kan, Jingwen Zhang, Xiaodong Sun, Zhentao Guo
Summary: Diabetic kidney disease (DKD) is a serious complication of diabetes and is the primary cause of end-stage renal disease. Current treatment strategies primarily focus on the inhibition of the renin-angiotensin-aldosterone system and the attainment of blood glucose control. Traditional Chinese medicine (TCM) treatment with TCM monomers derived from Chinese herbs has shown potential in modulating therapeutic targets and improving outcomes in DKD, offering a promising new direction for future research in the field.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Pharmacology & Pharmacy
Caiyi Long, Haoyue Feng, Zheng Liu, Zihan Li, Jun Liu, Yayi Jiang, Rensong Yue
Summary: This study conducted a network meta-analysis to evaluate the efficacy and safety of traditional Chinese medicine injections (TCMIs) in the treatment of diabetic kidney disease (DKD). The results showed that TCMIs combined with alprostadil injection (PGE1) were more effective than PGE1 alone. PGE1+HQI and PGE1+SKI were found to be the most effective treatments. However, further investigation on the safety of TCMI treatment is needed, and larger-scale, double-blind, multicentre RCTs are required to validate these findings.
FRONTIERS IN PHARMACOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Li-Ying Xu, Bin-Yan Yu, Lu-Sha Cen
Summary: A well-designed study by Li et al showed that modified Xiaochaihu decoction (MXD) may be an alternative therapy for GERD beyond proton pump inhibitors (PPIs). However, the lack of records of side effects and rescue medication was a limitation, and further observation is needed for long-term GERD rehabilitation with MXD therapy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Guangjun Song, Junmiao Zhuang, Xingrong Wang
Summary: This retrospective study evaluated the clinical efficacy of Chinese herbal footbath plus traditional Chinese medicine (TCM) decoction in diabetic peripheral neuropathy. The results showed that this treatment can significantly improve nerve conduction velocity, reduce blood glucose levels, alleviate symptoms, and enhance clinical efficacy.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Rongrong Zhou, Yujiao Zheng, Xuedong An, De Jin, Fengmei Lian, Xiaolin Tong
Summary: A new clinical strategy of dosage modification for Traditional Chinese Medicine prescriptions was proposed to evaluate clinical efficacy and guide clinical medication. The study analyzed two randomized controlled trials to explore key indications and appropriate critical values for dosage modification in the treatment of newly diagnosed type 2 diabetes mellitus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Respiratory System
Miao Zhou, Hailong Zhang, Fenglei Li, Zhefeng Yu, Chengbo Yuan, Brian Oliver, Jiansheng Li
Summary: The PD program showed better 6MWD results in IPF patients compared to the exercise and control groups. It is safe and effective, serving as a rehabilitation intervention to increase exercise tolerance and a suitable alternative for PR.
Article
Endocrinology & Metabolism
Yu-Xin Zhang, Yan-Jiao Zhang, Run-Yu Miao, Xin-Yi Fang, Jia-Hua Wei, Yu Wei, Jia-Ran Lin, Jia-Xing Tian
Summary: This study evaluated the efficacy of Traditional Chinese Medicine (TCM) decoctions for the treatment of diabetic gastroparesis (DGP) using Bayesian network meta-analysis. The results suggest that Banxia Xiexin Decoction (BXXD) + western medicine and Simo decoction (SMD) + western medicine may be potential optimal treatments. Further large-sample, double-blind, multi-center randomized controlled trials are needed to validate these findings.
WORLD JOURNAL OF DIABETES
(2023)
Article
Pharmacology & Pharmacy
Jiansheng Li, Xue-qing Yu, Yang Xie, Shu-guang Yang, Limin Zhao, Miao Zhou, Yong Meng
Summary: The study aimed to evaluate the efficacy and safety of traditional Chinese medicine (TCM) treatment for idiopathic pulmonary fibrosis (IPF). The results showed that TCM treatment significantly reduced acute exacerbations, improved pulmonary function, health-related quality of life, exercise capacity, and symptoms, with acceptable side-effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Integrative & Complementary Medicine
Ziteng Hu, Lidong Gao, Chengxian Li, Alberto Cucco, Shang Wang, Weiling Yuan, Fan Zhang, Shuai Kang, Min Wang
Summary: Longdan Xiegan decoction (LDXGD) is more effective in treating eczema compared to conventional Western medicine, but further studies are needed to confirm these results due to limitations in the quality of included studies.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Clinical Neurology
Ning Liang, Yaxin Chen, Sihong Yang, Changhao Liang, Lidong Gao, Shang Wang, Yanping Wang, Zhanjun Zhang, Nannan Shi
Summary: This study found that Chinese Herbal Medicine, particularly Ginko leaf extracts, could help prevent cognitive decline and improve cognitive function and ability in daily living activities for individuals with mild cognitive impairment. Although the quality of the included trials was relatively low, these findings are still significant.
FRONTIERS IN NEUROLOGY
(2022)
Review
Integrative & Complementary Medicine
Li-dong Gao, Shang Wang, Li Zhang, Wei-ling Yuan, Xin-yao Jin, Yi-hua Fan, Bao-he Wang
Summary: This systematic review and meta-analysis evaluated the efficacy of Shenlingbaizhusan (SLBZS) for antibiotic-associated diarrhea (AAD). The results showed that adding SLBZS to conventional therapy can improve the clinical efficacy of AAD, shorten the duration of diarrhea, and improve blood indicators. However, the current level of evidence is low, and more high-quality RCTs with larger sample sizes are needed to confirm and fully elucidate the efficacy of SLBZS.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Plant Sciences
Vinayak Nayak, Sushmita Patra, Shrushti Rout, Atala Bihari Jena, Rohit Sharma, Kali Prasad Pattanaik, Jay Singh, Shyam S. Pandey, Ravindra Pratap Singh, Sanatan Majhi, Kshitij R. B. Singh, Rout George Kerry
Summary: This study introduces a customized engineering and designing approach for novel nanotherapeutics, which involves the use of polymeric nanoparticles loaded with specific phytocompounds and coated with an antibody targeting the transferrin receptor. This approach aims to effectively tackle AD-related neuroinflammation by crossing the Blood-Brain Barrier and interacting with target molecules within the brain.
Article
Plant Sciences
Zhi Shang, Yating Gao, Yan Xue, Congcong Zhang, Jiahao Qiu, Yihan Qian, Miao Fang, Xin Zhang, Xuehua Sun, Xiaoni Kong, Yueqiu Gao
Summary: This study investigated the mechanism of Shenge Formula (SGF) in the treatment of nonalcoholic fatty liver disease (NAFLD) using proteomics strategy. The results revealed that SGF could regulate the lipid metabolism and energy consumption process of hepatocytes to treat NAFLD.
Article
Plant Sciences
Long You, Ting Shen, Weicheng Hu, Jae Youl Cho
Summary: By activating growth factor receptors such as EGFR and HER2, protopanaxatriol (PPT) can regulate skin moisturizing factors and multiple signaling pathways, thereby protecting and moisturizing the skin.
Article
Plant Sciences
Lingmei Li, Lei Li, Ce Cao, Fan Guo, Aoao Wang, Li Lin, Zixin Liu, Hongxu Meng, Peng Zhang, Gaojie Xin, Jianxun Liu, Junguo Ren, Jianhua Fu
Summary: The study found that Shuangshen Ningxin Capsule (SSNX) has a protective effect against myocardial ischemia-reperfusion injury. It works by correcting abnormal myocardial energy metabolism, changing the levels and distribution patterns of phospholipids, and stabilizing the structure of the myocardial cell membrane. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) can be used to detect the spatial distribution of small molecule metabolites in the myocardium.
Article
Plant Sciences
Nidhi Sharma, Ramakrishna Sistla, Sai Balaji Andugulapati
Summary: The study investigates the anti-fibrotic activity of Yohimbine hydrochloride (YHC) in chronic liver injury. The results show that YHC can reduce inflammation and fibrosis, potentially making it a potential lead compound for liver fibrosis treatment.
Article
Plant Sciences
Tao-tao Wang, Cheng-yong Yang, Li Peng, Li Li, Nan-ting Chen, Xue Feng, Jing Xie, Ting-chun Wu, Tao Xu, Yun-zhi Chen
Summary: QSYQ has been found to have an anti-atherosclerotic effect by targeting TTC39B-LXR mediated reverse cholesterol transport in the liver. QSYQ not only promotes reverse cholesterol transport, but also improves fatty liver and protects liver function.
Article
Plant Sciences
Zhuo Liu, Yuli Geng, Yanjing Huang, Runan Hu, Fan Li, Jiahui Ding, Wenwen Ma, Haoxu Dong, Kunkun Song, Xiaohu Xu, Xiao Wu, Yufan Song, Mingmin Zhang
Summary: This study investigated the therapeutic efficacy of the Bushen Antai recipe (BAR) in abortion-prone mice and explored its potential mechanisms related to myeloid-derived suppressor cells (MDSCs). The results showed that BAR improved embryo absorption rate and increased the number of MDSCs, promoting normal pregnancy processes.
Article
Plant Sciences
Xue-Ping Yang, Jia-Hua Huang, Fan-Long Ye, Qing-Yun Yv, Sheng Chen, Wen-Wei Li, Min Zhu
Summary: This study found that ECH exerts neuroprotective effects on Parkinson's disease (PD) by regulating the expression of the TLR2/NF-kappa B/NLRP3 axis and reducing the expression of alpha-syn.
Article
Plant Sciences
Lihui Qian, Sirui Huang, Xiaoli Liu, Yongxia Jiang, Yongqu Jiang, Yue Hu, Zhou Yang
Summary: This study highlights the potential use of morroniside in treating post-stroke depression (PSD) by activating the MiR-409-3p-mediated BDNF/TrkB signaling pathway.
Article
Plant Sciences
Jiahui Wu, Hoi Lam Zhang, Suisui Guo, Xin Li, Tingxia Dong, Yue Zhu, Karl Wah Keung Tsim
Summary: This study revealed the significant MDR-preventing effects of Acori Tatarinowii Rhizoma (ATR) in fluoxetine-induced Escherichia coli (E. coli). ATR reduced the accumulation of fluoxetine in bacteria and reversed the fluoxetine-induced membrane damage and superoxide response. The polysaccharide fraction of ATR exhibited the most significant anti-MDR activity.
Article
Plant Sciences
Chao-Sheng Lu, Chen-Yu Wu, Yi-Hong Wang, Qing-Qing Hu, Rong-Yue Sun, Min-Jie Pan, Xin-Yu Lu, Ting Zhu, Shuang Luo, Hong-Jing Yang, Dan Wang, Hong-Wei Wang
Summary: This study demonstrates the potential of icariin in alleviating testicular dysfunction induced by T1D, with the involvement of AMPK-mediated Nrf2 activation and NF-kappa B p65 inhibition.
Article
Plant Sciences
Hongkang Zhu, Fanglin Shen, Xiaochen Wang, He Qian, Yu Liu
Summary: This study explores the therapeutic effect and underlying mechanism of chlorogenic acid (CGA) in alleviating sleep deprivation-induced cognitive deficits and neuroinflammation. By interacting with the gut microbiota, CGA improves intestinal barrier, regulates immune function, and enhances hippocampal-dependent spatial memory via Nrf2/PPAR signaling pathways. This research provides important insights into the clinical application of CGA in sleep-related disorders.
Article
Plant Sciences
Meng Liu, Pengli Guo, Mengnan Zeng, Yuhan Zhang, Jufang Jia, Yanling Liu, Xu Chen, Haixue Kuang, Weisheng Feng, Xiaoke Zheng
Summary: This study found that Fre D and Reh C improved S-AKI through the ER-TLR4-IL-1β pathway, and ERα and ERβ may have direct or indirect interactions with TLR4.
Review
Plant Sciences
Puja Ghosh, Niloy Patari, Chennu Manisha, Duraiswamy Basavan, Velammal Petchiappan, Antony Justin
Summary: This article reviews the possible mechanisms of alternative treatment using lectins for cancer, particularly MDRC cancer. Lectins have the ability to reverse drug resistance mechanisms and show synergistic effects when combined with complementary medicine. They can also serve as nano drug carriers for targeted delivery.
Article
Plant Sciences
Tian Lan, Xiao-juan Geng, Si-jia Zhang, Xi-xi Zeng, Jun-jie Ying, Yi Xu, Shi-yu Liu, Ping Li, Yu-hua Tong, Wen Wang, Zhu-jun Mao, Si-wei Wang
Summary: This study investigates the impact of SNS on MAFLD in mice and explores its underlying molecular mechanisms. The results show that SNS effectively reduces lipid accumulation and improves MAFLD through the activation of AMPK and the modulation of lipid metabolism-related proteins.