Fungal cell membrane-promising drug target for antifungal therapy

Plasma membrane organization promotes virulence of the human fungal pathogen Candida albicans

(2016) Lois M. Douglas et al.   JOURNAL OF MICROBIOLOGY

Re-engineering of PIP3-antagonist triazole PITENIN's chemical scaffold: development of novel antifungal leads

(2016) Sravani Pulya et al.   RSC Advances

Structural Insights into Binding of the Antifungal Drug Fluconazole to Saccharomyces cerevisiae Lanosterol 14α-Demethylase

(2015) Alia A. Sagatova et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Clerodane type diterpene as a novel antifungal agent from Polyalthia longifolia var. pendula

(2015) Asish K. Bhattacharya et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Azole antifungals: 35 years of invasive fungal infection management

(2015) David Allen et al.   Expert Review of Anti-Infective Therapy

How to bolster the antifungal pipeline

(2015) D. W. Denning et al.   SCIENCE

Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids

(2015) Visesato Mor et al.   mBio

Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation

(2015) Gorakhnath R. Jachak et al.   ACS Medicinal Chemistry Letters

Synergistic combinations of antifungals and anti-virulence agents to fight againstCandida albicans

(2015) Jinhui Cui et al.   Virulence

Coping with Stress and the Emergence of Multidrug Resistance in Fungi

(2015) Erika Shor et al.   PLoS Pathogens

Antifungal activity and mechanism of action of carvacrol and thymol against vineyard and wine spoilage yeasts

(2014) Pradnya S. Chavan et al.   FOOD CONTROL

Combination of fluconazole with non-antifungal agents: A promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery

(2014) Shuyuan Liu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Mechanism of action of novel synthetic dodecapeptides against Candida albicans

(2013) Indresh Kumar Maurya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The 3-hydroxy-3-methylglutaryl coenzyme-A reductases from fungi: A proposal as a therapeutic target and as a study model

(2013) Dulce Andrade-Pavón et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

A convenient cellular assay for the identification of the molecular target of ergosterol biosynthesis inhibitors and quantification of their effects on total ergosterol biosynthesis

(2013) Christoph Müller et al.   STEROIDS

Ergosterol biosynthesis in Aspergillus fumigatus: its relevance as an antifungal target and role in antifungal drug resistance

(2013) Laura Alcazar-Fuoli et al.   Frontiers in Microbiology

Phenyl aldehyde and propanoids exert multiple sites of action towards cell membrane and cell wall targeting ergosterol in Candida albicans

(2013) Mohd Sajjad Khan et al.   AMB Express

An Integrated Approach for Identification and Target Validation of Antifungal Compounds Active against Erg11p

(2012) Dominic Hoepfner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ERGOSTEROL BIOSYNTHESIS: A FUNGAL PATHWAY FOR LIFE ON LAND?

(2012) Sebastien Dupont et al.   EVOLUTION

Inhibitors of V-ATPase Proton Transport Reveal Uncoupling Functions of Tether Linking Cytosolic and Membrane Domains of V 0 Subunit a (Vph1p)

(2012) Chun-Yuan Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polyene antibiotic that inhibits membrane transport proteins

(2012) Y. M. te Welscher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic antifungal activity of statin–azole associations as witnessed by Saccharomyces cerevisiae- and Candida utilis-bioassays and ergosterol quantification

(2012) María Eugenia Cabral et al.   REVISTA IBEROAMERICANA DE MICOLOGIA

The Monoamine Oxidase A Inhibitor Clorgyline Is a Broad-Spectrum Inhibitor of Fungal ABC and MFS Transporter Efflux Pump Activities Which Reverses the Azole Resistance of Candida albicans and Candida glabrata Clinical Isolates

(2011) Ann R. Holmes et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Confronting the Challenges of Natural Product-Based Antifungal Discovery

(2011) Terry Roemer et al.   CHEMISTRY & BIOLOGY

Antifungal activity of novel synthetic peptides by accumulation of reactive oxygen species (ROS) and disruption of cell wall against Candida albicans

(2011) Indresh Kumar Maurya et al.   PEPTIDES

An insight into the antifungal pipeline: selected new molecules and beyond

(2010) Luis Ostrosky-Zeichner et al.   NATURE REVIEWS DRUG DISCOVERY

Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity

(2010) Amber Khan et al.   RESEARCH IN MICROBIOLOGY

Three-Dimensional Model of Lanosterol 14 -Demethylase from Cryptococcus neoformans: Active-Site Characterization and Insights into Azole Binding

(2009) C. Sheng et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modulation of the Antifungal Activity of New Medicinal Plant Extracts Active on Candida glabrata by the Major Transporters and Regulators of the Pleiotropic Drug-Resistance Network in Saccharomyces cerevisiae

(2009) Marcin Kolaczkowski et al.   Microbial Drug Resistance

Synthesis and antimicrobial activity of β-lactam–bile acid conjugates linked via triazole

(2008) Namdev S. Vatmurge et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agents

(2008) Sudhir N. Bavikar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of bile acid dimers linked with 1,2,3-triazole and bis-β-lactam

(2008) Namdev S. Vatmurge et al.   ORGANIC & BIOMOLECULAR CHEMISTRY