Article
Substance Abuse
Canyon Foot, Philip T. Korthuis, Judith I. Tsui, Sean X. Luo, Brian Chan, Ryan R. Cook
Summary: The aim of this study was to investigate the impact of ongoing stimulant use on the return to illicit opioid use after medication for opioid use disorder (MOUD) initiation. The findings suggest that individuals who use stimulants are more likely to relapse to ongoing non-prescribed opioid use, especially among those who initiate buprenorphine.
Article
Medicine, General & Internal
Arnt F. A. Schellekens, Stijn E. Veldman, Eka S. D. Suranto, Steffie M. van Rijswijk, Selina E. van der Wal, Aart H. Schene, Marleen H. C. T. van Beek
Summary: Rotation to buprenorphine/naloxone (BuNa) in patients with chronic non-cancer pain (CNCP) and opioid use disorder (OUD) was associated with reductions in opioid misuse, craving, severity of co-occurring psychiatric symptoms, and self-reported pain perception. BuNa as an opioid agonist treatment may be a beneficial strategy in this patient population.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Substance Abuse
Julia R. Benville, Peggy Compton, Nicholas A. Giordano, Martin D. Cheatle
Summary: The study found that patients with CNCP and OUD on methadone therapy endorse levels of social support comparable to those without OUD, however those on buprenorphine therapy report significantly less support, bringing implications for OUD treatment outcomes.
DRUG AND ALCOHOL DEPENDENCE
(2021)
Article
Anesthesiology
Stijn Veldman, Maria van Beek, Steffie van Rijswijk, Hannah Ellerbroek, Hans Timmerman, Selina van der Wal, Monique Steegers, Arnt Schellekens
Summary: This study investigated the added value of buprenorphine or naloxone (BuNa) in patients with chronic noncancer pain (CNCP) and opioid use disorder (OUD). The results showed that conversion to BuNa led to decreased self-reported pain, increased pain thresholds and tolerance, and improved quality of life (QoL) in these patients.
Article
Surgery
William J. Olney, Eric G. Johnson, Cassidy Potts, J. Thomas Murphy, Douglas R. Oyler
Summary: This study evaluated the impact of perioperative continuation of buprenorphine on the use of opioid medications in patients with substance use disorder. The results showed that 43.4% of patients who continued buprenorphine did not use opioid medications during days 1-7 of admission, compared to only 3.1% of patients who withheld buprenorphine. The study concluded that perioperative continuation of buprenorphine reduces the use of opioid medications without affecting pain scores.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Obstetrics & Gynecology
Erica Holland, Liza Gibbs, Nicole Z. Spence, Monica Young, Martha M. Werler, Zeyu Guang, Kelley Saia, Brian T. Bateman, Rachel Achu, Elisha M. Wachman
Summary: This study aimed to compare postpartum opioid consumption and prescriptions among patients with opioid use disorder and opioid-naive counterparts. The results showed that patients with opioid use disorder consumed significantly greater quantities of opioids after cesarean delivery, regardless of treatment with methadone, buprenorphine, or no medication.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Psychology, Clinical
Karlyn A. Edwards, Kevin E. Vowles, R. Kathryn McHugh, Kamilla L. Venner, Katie Witkiewitz
Summary: This study examined changes in pain intensity and interference during BUP/NX maintenance treatment, finding that for a subgroup of patients, high levels of pain intensity and interference remained unchanged.
JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY
(2022)
Article
Clinical Neurology
Matthew S. Ellis, Zachary Kasper, Theodore Cicero
Summary: The study shows that many OUD treatment programs do not effectively manage chronic pain in patients, increasing the likelihood of opioid relapse. To improve outcomes, enhancing interdisciplinary collaboration and establishing evidence-based pain management policies are crucial.
Article
Health Care Sciences & Services
Susan L. Calcaterra, Steve Lockhart, Catherine Callister, Kaitlyn Hoover, Ingrid A. Binswanger
Summary: This study examined the facilitators and barriers to hospital-based opioid use disorder (OUD) treatment initiation and continuation from the perspective of patients and healthcare workers in the context of an addiction consultation service (ACS). The findings identified modifiable factors that facilitate OUD treatment, including the availability of in-hospital addiction expertise and the use of methadone or buprenorphine to manage opioid withdrawal.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Substance Abuse
Kara E. Rudolph, Ivan Diaz, Nima S. Hejazi, Mark J. van der Laan, Sean X. Luo, Matisyahu Shulman, Aimee Campbell, John Rotrosen, Edward V. Nunes
Summary: This study analyzed the mediation pathways to medication effect between homeless and non-homeless individuals with opioid use disorder, finding that the difference in medication effectiveness between extended-release naltrexone and buprenorphine-naloxone was largely explained by factors such as adherence, illicit opioid use, depressive symptoms, and pain, especially among non-homeless participants.
Article
Health Care Sciences & Services
Jarratt D. Pytell, Michael D. Sklar, Joseph Carrese, Darius A. Rastegar, Christine Gunn, Geetanjali Chander
Summary: The study examined patient perceptions of the chronic disease model of addiction among individuals with OUD in long-term sustained remission. It found that patients' maintenance of an OUD identity influenced their attitudes towards treatment and strategies for maintaining abstinence. The research highlighted the importance of understanding patient perspectives of OUD identity for providing patient-centered care and improving outcomes.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Substance Abuse
Eleasa Sokolski, Emily Skogrand, Amelia Goff, Honora Englander
Summary: This study examined the efficacy and feasibility of a rapid low-dose buprenorphine initiation protocol in the hospital setting. The results showed that rapid low-dose buprenorphine initiation is a feasible and well-tolerated alternative for hospitalized patients.
JOURNAL OF ADDICTION MEDICINE
(2023)
Article
Substance Abuse
Madeline C. Frost, Julie E. Richards, John R. Blosnich, Eric J. Hawkins, Judith I. Tsui, Jennifer Edelman, Emily C. Williams
Summary: In individuals with opioid use disorder (OUD), clinically recognized suicidality may increase the likelihood of initiating medications for OUD (MOUD) but decrease the likelihood of continuation. Efforts to improve both initiation and retention rates for patients with suicidality are necessary.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Article
Health Care Sciences & Services
Jiunling Janet Ho, Katie Fitzgerald Jones, Zachary Sager, Kyle Neale, Julie W. Childers, Elizabeth Loggers, Jessica S. Merlin
Summary: This study explored the barriers for hospice and palliative care (HPC) clinicians in prescribing buprenorphine as medication treatment for opioid use disorder (OUD). The results showed that despite their interest, HPC clinicians faced various barriers, including discomfort managing concurrent pain, concerns about impacts on practice, unsupportive practice culture, etc. To improve care for patients with painful serious illness and OUD, measures such as tailored clinician education, mentorship on buprenorphine use, and changes in culture and practice are proposed.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Article
Oncology
Emese Zsiros, Jason Ricciuti, Steven Gallo, Deanna Argentieri, Kristopher Attwood, Wenyan Ji, Alan Hutson, Paul Visco, Devon Coffey, Grazyna Riebandt, Jaron Mark, Aaron Varghese, Suzanne M. Hess, Thomas Furlani, Andrew Fabiano, Mark Hennon, Sai Yendamuri, Eric C. Kauffman, Kimberly E. Wooten, Wesley L. Hicks, Jessica Young, Kazuaki Takabe, Kunle Odunsi, Amy A. Case, Brahm H. Segal, Candace S. Johnson, Boris Kuvshinoff, Steven Nurkin, Gyorgy Paragh, Oscar de Leon-Casasola
Summary: Restricting the prescription of opioids to 3 or fewer days after surgery can effectively manage postsurgical acute pain and reduce the risk of chronic opioid use in surgical patients.
Editorial Material
Health Care Sciences & Services
Madison Irwin, Ketti S. Petersen, Michael A. Smith
Summary: Most cancer-related pain patients use opioids for management, but using opioids in pregnant patients poses risks. Buprenorphine, a unique opioid, may have benefits for cancer-related pain in pregnant patients, but there is limited data available.
JOURNAL OF PALLIATIVE MEDICINE
(2021)
Article
Health Care Sciences & Services
Madison Irwin, William Gunther, Patricia Keefer, D'Anna Saul, Sharon A. Singh, Jennifer Wright, Michael A. Smith
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2021)
Letter
Health Care Sciences & Services
Madison N. Irwin, Vicki L. Ellingrod, Michael A. Smith
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2022)
Letter
Oncology
Nour K. Kadouh, Stacy Lang, Mark Shamoun, Eric L. Scott, Sharon A. Singh, Michael A. Smith
PEDIATRIC BLOOD & CANCER
(2022)
Article
Medicine, General & Internal
Kao-Ping Chua, Jennifer F. Waljee, Michael A. Smith, Shreya Bahl, Romesh P. Nalliah, Chad M. Brummett
Summary: This study aims to estimate the prevalence of delayed dispensing of opioid prescriptions from surgeons and dentists, assess the maximum period allowed between prescription writing and dispensing, and evaluate whether laws shortening this period decrease delayed dispensing.
Article
Anesthesiology
Kyle Quirk, Michael A. Smith
Summary: This study aimed to explore risk factors for the development of neuropsychiatric adverse effects in ketamine-treated pain. The findings suggest that it is difficult to predict which patients are more likely to experience these adverse effects. Further research is needed to determine the safety and effectiveness of benzodiazepines in mitigating these adverse effects.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2022)
Article
Anesthesiology
Jacqueline C. Dela Pena, Vincent D. Marshall, Michael A. Smith
Summary: This study investigated the adherence to cancer pain management guidelines among cancer patients and its impact on pain control and length of hospital stay. The results showed that the majority of patients had poor adherence to the guidelines, and patients who adhered to the guidelines had shorter hospital stays and lower pain scores. However, the outcomes for opioid-tolerant patients were still inadequate, indicating a need for improvement in pain management strategies.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2022)
Review
Anesthesiology
Joseph Elijah, Kelly Powell, Michael A. Smith
Summary: This review evaluated the utility of capsaicin for improvement of sleep quality and fatigue associated with fibromyalgia. The existing evidence is insufficient to support recommending capsaicin as adjunctive therapy for improvement in sleep quality and fatigue.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2022)
Article
Anesthesiology
Madison N. Irwin, Michael A. Smith
Summary: Chronic overlapping pain conditions (COPCs) are a collection of chronic pain syndromes that share underlying nociplastic pathophysiology. Validated code sets using ICD codes were generated to identify COPCs in administrative datasets. This study validated an ICD-9 code set for identifying COPCs and found high levels of diagnostic accuracy.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Isabelle Zerfas, Reagan McGinn, Michael A. Smith
Summary: Despite the complexity and under-treatment of pain in cancer patients, managing pain in pregnant cancer patients is even more challenging. This review aims to provide clinicians with knowledge about the pain experienced by pregnant cancer patients and the medications that can be used to help manage it.
Article
Anesthesiology
Lee A. Kral, Jeffrey J. Bettinger, Christine M. Vartan, Katherine Hadlandsmyth, Justin Kullgren, Michael A. Smith
Summary: This survey describes the current practices of pain and palliative care pharmacists in opioid tapering. The results show that pharmacists play an important role in providing recommendations and monitoring patients during the taper. The common indications for initiating an opioid taper are abuse/misuse, reduced efficacy, and adverse drug reactions.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2022)
Article
Anesthesiology
Madison N. Irwin, Kyle Quirk, Andrea Banner, Kevin Hosseini, Michael A. Smith
Summary: This retrospective cohort study found that both direct switch and cross-taper strategies are reasonable for rotating between gabapentinoids in the inpatient setting. There was no significant difference in success rates between the two strategies, but patients with normal renal function were more likely to be successful with a direct switch strategy.
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2021)
Article
Nursing
Katherine H. Cho, Emily J. Ashjian, Michael Smith, Amy Barton Pai
NEPHROLOGY NURSING JOURNAL
(2020)
Article
Anesthesiology
Kyle Quirk, Michael A. Smith
JOURNAL OF PAIN & PALLIATIVE CARE PHARMACOTHERAPY
(2020)