Recent progress in biologically active indole hybrids: a mini review

The indole moiety is one of the most widespread heterocycles found in both natural products and biological systems. Indoles have important biological activities including anticancer, antioxidant, anti-inflammatory, antifungal, anticholinesterase, and antibacterial properties. Scientists are therefore interested in the synthesis of biologically active indole-based hybrids such as indole-coumarin, indole-chalcone, indole-isatin, indole-pyrimidine and so on, with the aim of improving activity, selectivity, and mitigating side effects. This review will discuss the newly synthesized indole-based hybrids along with their biological activity which will be useful in drug discovery and development.

Automated summary

The indole moiety is a commonly found heterocycle in natural products and biological systems. Indoles possess important biological activities, including anticancer, antioxidant, and anti-inflammatory properties. Scientists have been focusing on the synthesis of indole-based hybrids and studying their biological activity to enhance drug efficacy.