Synthesis of potent antagonists of receptors for growth hormone-releasing hormone with antitumor and anti-inflammatory activity

Cancer Statistics, 2021

(2021) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Signaling mechanisms of growth hormone-releasing hormone receptor in LPS-induced acute ocular inflammation

(2020) Wei Cheng Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity

(2020) Nektarios Barabutis et al.   HORMONE AND METABOLIC RESEARCH

Splice variant of growth hormone-releasing hormone receptor drives esophageal squamous cell carcinoma conferring a therapeutic target

(2020) Xiao Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response

(2020) Jessie Huang et al.   Cell Stem Cell

Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of human malignant pleural mesothelioma

(2019) Tania Villanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth Hormone-Releasing Hormone Receptor Antagonist Modulates Lung Inflammation and Fibrosis due to Bleomycin

(2019) Chongxu Zhang et al.   LUNG

Mycobacterium abscessus—Bronchial Epithelial Cells Cross-Talk Through Type I Interferon Signaling

(2019) Chongxu Zhang et al.   Frontiers in Immunology

A new approach to the treatment of acute myeloid leukaemia targeting the receptor for growth hormone-releasing hormone

(2018) Joaquin J. Jimenez et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inhibition of experimental small-cell and non-small-cell lung cancers by novel antagonists of growth hormone-releasing hormone

(2018) Haibo Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Growth hormone-releasing hormone antagonists reduce prostatic enlargement and inflammation in carrageenan-induced chronic prostatitis

(2018) Petra Popovics et al.   PROSTATE

Agonists of growth hormone-releasing hormone (GHRH) inhibit human experimental cancers in vivo by down-regulating receptors for GHRH

(2018) Andrew V. Schally et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P53, GHRH, inflammation and cancer

(2018) Nektarios Barabutis et al.   EBioMedicine

Synthesis and structure-activity studies on novel analogs of human growth hormone releasing hormone (GHRH) with enhanced inhibitory activities on tumor growth

(2017) Marta Zarandi et al.   PEPTIDES

Discovery of LHRH and development of LHRH analogs for prostate cancer treatment

(2017) Andrew V. Schally et al.   PROSTATE

Inhibitory Effects of Antagonists of Growth Hormone-Releasing Hormone (GHRH) in Thyroid Cancer

(2017) Helena Pópulo et al.   Hormones & Cancer

Growth hormone-releasing hormone receptor antagonists inhibit human gastric cancer through downregulation of PAK1–STAT3/NF-κB signaling

(2016) Jinfeng Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease

(2016) Miklos Jaszberenyi et al.   Aging-US

New therapies for relapsed castration-resistant prostate cancer based on peptide analogs of hypothalamic hormones

(2015) AndrewV Schally et al.   ASIAN JOURNAL OF ANDROLOGY

Antagonists of growth hormone-releasing hormone suppress in vivo tumor growth and gene expression in triple negative breast cancers

(2015) Roberto Perez et al.   Oncotarget

Novel GHRH antagonists suppress the growth of human malignant melanoma by restoring nuclear p27 function

(2014) Luca Szalontay et al.   CELL CYCLE

Effect of Tesamorelin on Visceral Fat and Liver Fat in HIV-Infected Patients With Abdominal Fat Accumulation

(2014) Takara L. Stanley et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Preclinical efficacy of growth hormone-releasing hormone antagonists for androgen-dependent and castration-resistant human prostate cancer

(2014) C. D. Fahrenholtz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antagonist of GH-releasing hormone receptors alleviates experimental ocular inflammation

(2014) Yong Jie Qin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging structural insights into biased GPCR signaling

(2014) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

Synthesis of new potent agonistic analogs of growth hormone-releasing hormone (GHRH) and evaluation of their endocrine and cardiac activities

(2013) Renzhi Cai et al.   PEPTIDES

Suppression of the proliferation of human U-87 MG glioblastoma cells by new antagonists of growth hormone-releasing hormone in vivo and in vitro

(2013) Miklos Jaszberenyi et al.   Targeted Oncology

Growth Hormone–Releasing Hormone Effects on Brain γ-Aminobutyric Acid Levels in Mild Cognitive Impairment and Healthy Aging

(2013) Seth D. Friedman et al.   JAMA Neurology

Effects of Growth Hormone–Releasing Hormone on Cognitive Function in Adults With Mild Cognitive Impairment and Healthy Older Adults

(2012) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Antagonists of growth hormone-releasing hormone inhibit growth of androgen-independent prostate cancer through inactivation of ERK and Akt kinases

(2012) F. G. Rick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel antagonists of growth hormone-releasing hormone inhibit growth and vascularization of human experimental ovarian cancers

(2011) Anna Klukovits et al.   CANCER

Antineoplastic Action of Growth Hormone-Releasing Hormone (GHRH) Antagonists

(2011) Agnieszka Siejka et al.   Recent Patents on Anti-Cancer Drug Discovery

Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects

(2009) Lucila Sackmann-Sala et al.   GROWTH HORMONE & IGF RESEARCH